Klion d side effects what to do

Very often, the female body becomes vulnerable to pathological processes that are caused by pathogenic microflora. Vaginal Trichomonas, fungi of the genus Candida can cause serious diseases, which are accompanied by pain and itching.

They create a risk of infecting a sexual partner, and at the time of birth they can infect a newborn. To eliminate these pathologies, medications are prescribed in the form of suppositories, which are used topically in gynecology and are called Klion-D.

Compound

Klion-D vaginal tablets contain the following components in equal proportions:

Metronidazole (a drug that suppresses bacterial microflora and has an antiprotozoal effect).
Miconazole (antifungal agent)

Additional components included in this substance include:

Silicon Acid.
Magnesium sterate.
Monohybrid lactose.
Povidone.

These additional ingredients ensure good absorption and tolerability of this drug.

Medicine "Klion-D": price

Reviews, instructions, contraindications - this is important information. But it’s no secret that many people are also guided by the cost of a particular drug. Of course, the exact figure will depend on many factors, including the manufacturer and place of purchase.

The cost of a package consisting of 10 vaginal tablets ranges from 500 to 700 rubles. It is worth noting that this amount in most cases is enough to complete the full course of treatment.

Pharmacological effects of Klion-D

Due to the fact that this drug optimally combines two potent dosage forms, the therapeutic effect in the treatment of fungal pathologies of various origins is achieved very quickly.

Miconazole affects pathogenic microflora at the cellular level , it destroys their membrane, after which they lose their ability to reproduce and the microorganisms die. The good qualities of this ingredient include the extent to which its use does not increase the concentration in the human bloodstream.
The maximum peak of its effect is observed 8 hours after a single use.
The good therapeutic effect of metronidazole is based on the ability of this chemical compound to penetrate the DNA structure of microorganisms, this disrupts the process of cell division, inhibits their growth, and prevents them from reproducing.
After the period of treatment with Klion-D has expired , its half-life products are excreted along with the urine (the color of the urine may change to brown or reddish).

Pharmacodynamics and pharmacokinetics

The effect of the drug is due to the complex effect on the vaginal microflora of its constituent components.

Miconazole is an antifungal agent that destroys dermatophytes and yeasts, but does not disturb the pH or destroy healthy microflora in the vagina. The substance directly affects the synthesis of lipid components in the fungal membrane, thereby destroying it. It does not penetrate into the blood and is not found in the kidneys and products of the excretory organs; 90% remains in the vagina. The maximum concentration is after 8 hours.

Metronidazole is an antibiotic. It inhibits the process of RNA and DNA synthesis of destructive bacteria by restoring the 5-nitro group by transport proteins inside the cell. After entering the vagina, it penetrates into the blood. Its maximum concentration in the blood (half of the administered dose) can be detected after 9 hours.

Dosage of Klion-D

Klion-D vaginal suppositories usually need to be inserted once a day. They are best administered before going to bed.
After their introduction, it is recommended to get out of bed as little as possible. This will ensure good absorption of the medicine.
The duration of treatment is determined by the doctor, usually it does not exceed 10 days.
It is best when Klion-D therapy is performed in combination, using tablet forms.

What do the doctor's say? Patient reviews

Before using a particular medicine, it is always useful to study all available information. Of course, it is worth familiarizing yourself with the opinions of experts. What do doctors say about the drug "Clio-D"? Reviews are positive. The medicine allows you to quickly cope with the infection and avoid the development of possible complications.

Patients also respond well to the product. Unpleasant itching, burning and other symptoms of vaginal infection disappear after a few days. Vaginal tablets are small and easy to administer intravaginally. Adverse reactions are recorded very rarely.

It is also convenient that the drug with the same composition is available in other forms, including tablets for oral administration and solution for intravenous administration - with their help, therapy can be supplemented.

Mode of application

Before using Klion-D vaginal suppositories, you must perform the following procedure:

A woman is recommended to do a good wash. In this case, it is necessary to use soft soapy substances that do not disrupt the normal acid-base balance. For this purpose, you can use a gel that does not contain dyes, or soap for children.
After this, the hands, especially the nail phalanges, must be treated with an alcohol-containing solution using a cotton swab.
Before inserting a vaginal suppository, you must take a lying position , moisten it in cool water, and insert it with the pointed end as deeply as possible into the vagina.

All these manipulations must be done quickly, since under the influence of the warmth of human hands, suppositories can lose their shape and consistency.

The use of Klion-D suppositories may be accompanied by an increase in vaginal discharge. This is not a dangerous sign, but the resulting stains on laundry can create problems during washing. To prevent this from happening, women are recommended to use sanitary pads throughout the course of treatment.

The drug "Klion-D": instructions for use

Reviews from doctors and patients indicate that the medicine really helps to cope with a lot of problems. However, you should not use the drug without permission - only a doctor can draw up the correct treatment regimen.

How to use the medicine “Klion-D” (suppositories) correctly? Reviews indicate that the instructions are quite simple. The tablet must be inserted deep into the vagina (it is advisable to carry out the procedure while lying down). It is recommended to pre-moisten the suppository in purified water. It is better to take the tablet immediately before bed - this will give the drug time to completely dissolve and be absorbed by the vaginal mucosa.

The course of therapy usually lasts 10 days. To achieve maximum effect, vaginal tablets are combined with oral metronidazole. Such treatment is recommended not only for the sick woman, but also for her sexual partner - this is the only way to prevent the development of re-infection.

Indications for use

Gynecological infection is the main area of application of Klion-D.

He is appointed:

When infected with Trichomonas.
In the case of candidal infections with a fungus of the genus candida.
Vaginitis of various etiologies.
Gardnerellosis.

Use of Klion-D suppositories during pregnancy

During the first trimester of pregnancy, the formation and formation of the internal organs of the future newborn occurs. Therefore, during this period, the use of candles should be avoided.

During subsequent pregnancy, the use of the drug is possible. But before this, the doctor carefully weighs all the pros and cons of this drug. Its appointment occurs in extreme cases, when a woman in labor really needs to eliminate the pathology that is caused by fungal microflora.

Also, Klion-D vaginal suppositories can be used before childbirth to cleanse the birth canal of pathological mycelium. This helps prevent infection of the newborn.

The ingredients of Klion-D suppositories pass into breast milk in small quantities, which makes it impossible to use this medicine. If an appointment nevertheless occurs, breastfeeding is temporarily stopped.

Using Klion-D for thrush

The course of treatment for this pathological disease should not exceed ten days. The recommended dose is a single use of vaginal suppositories before bedtime. Treatment is not carried out in the morning.

After 1 month, if necessary, the course of treatment can be repeated. If treatment is ineffective, a laboratory test must be performed.

Make a bacterial culture of vaginal contents and establish the tolerance of a drug that can resist bacterial microflora.

Use for trichomoniasis

The course of treatment, dosage, and method of application are exactly the same as for the treatment of thrush. It is also possible, if necessary, to extend the course after a month.

Use during menstruation

During the menstrual cycle, women experience bleeding from the vagina.

If you put a suppository with this drug at this time, it may partially dissolve in them, and as a result, it makes no sense to treat the disease, since its therapeutic effect is reduced, which leads to an incomplete cure from the pathological process of the disease.

It is necessary to interrupt the course of treatment for the entire period of menstruation, and after it ends, resume it again.

Use of Klion-D for kidney and liver diseases

As noted earlier, Klion-D suppositories are not prescribed for severe liver damage (cirrhosis, hepatitis of various etiologies).

Renal failure, in the final stages, also precludes the use of this drug.

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What do pharmacologists say about this drug?

This medicine is presented on the pharmacy market in a single form - vaginal tablets, so their effect is mainly of a local nature. The drug contains two known components:

First of all, we are talking about miconazole. This substance is a derivative of ergosterol or a mixture of fatty complexes of protozoan fungal cells. Due to its functions, the compound in question promotes the entry of large amounts of ordinary table salt and minerals into the cells of Candida fungi, which leads to their death. Miconazole is used to combat various fungal pathologies.
The second active component of this drug is metronidazole. This medicinal substance is widely used for various bacterial problems in many aspects of medicine. Metronidazole is used by surgeons, obstetricians-gynecologists, urologists and other doctors dealing with various infections. Its main function is to ensure the restoration of cells damaged by various harmful microorganisms.

After conducting numerous experiments, it turned out that these two substances complement each other perfectly. Therefore, the drug “Klion D” has become quite widespread among dermatologists and gynecologists.

The literature describes the use of KlionD during menstruation, but data on the results and consequences vary greatly.

Watch the video about the action of the drug:

Use of the drug for various diseases

The method of using vaginal tablets “Klion D” has several features. The thing is that suppositories require additional moisture, so right before administering the drug inside a woman, it is advisable to douche with warm water. A soap solution of weak consistency is also possible.

For trichomoniasis

In approximately 60 - 70% of cases, this drug is used to treat trichomonas vulvitis in women. Most often, experts recommend administering no more than one medicinal tablet per day.

The process of introducing the medicine into the patient’s vagina takes several minutes before the patient falls asleep. Most often, a woman needs 10 to 12 days for a complete recovery. However, quite often visible successes are not confirmed by laboratory studies. In this case, you have to take 2 tablets of the drug “Metronidazole” daily, 2 times a day per os (by mouth) 40 minutes before meals.

Treatment of thrush

Up to 30% of the female population of the world suffers from candidiasis or thrush at different times of life, and it should be noted that menstrual bleeding is quite often a stimulating factor. Therefore, the question of whether “Klion D” can be taken during menstruation is especially relevant for this disease.

It should be noted that when treating thrush, this drug is used daily for 12 to 14 days. The tablets require the same amount of moisture as in the treatment of trichomoniasis. The moment of administration of the drug is also not original: the medicine is best taken 15 - 20 minutes before bedtime in a supine position.

Doctors note that the course of taking the drug “Klion D” can be repeated several times until the result is obtained, however, in this case, laboratory monitoring of treatment is also required. According to the annotation, the medicine is able to resist all fungi of the Candida family, however, there are exceptions to any rule.

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Special conditions for drug treatment

When using “Klion D” to treat trichomonas or fungi, a woman should be aware of some specific requirements and conditions:

First of all, you should remember that this drug affects the human nervous system and can cause depression of attention, drowsiness, and apathy. If taking the drug provoked such a reaction, it is contraindicated to drive a car or work in precision and high-speed production, such as a conveyor belt.
“Klion D” can provoke increased transmission of pathogens of trichomoniasis and candidiasis to sexual partners. This occurs due to the aggressive effect of the drug on the female flora. It is recommended to stop all sexual intercourse for the duration of treatment.
Since the drug contains metronidazole, under its influence it is possible to change the blood formula of a sick woman: during the analysis, leukopenia or a decrease in the number of leukocytes to 50% below normal is present. Such a symptom may also indicate the development of disorders in the patient’s immune system.

And, of course, as with any medication, young ladies will be concerned about a possible overdose when taking the drug. If only vaginal tablets are used, then the question of overdose or poisoning does not even arise.

Side effects are possible only with the simultaneous use of Klion D and Metronidazole tablets. In this case, it is quite rare, but various manifestations from the gastrointestinal tract are possible, which can be relieved by stopping the drug and using activated charcoal along with gastric lavage. More severe symptoms require the intervention of acute poisoning specialists.

“Klion D” and menstruation

As mentioned above, this drug is used for female diseases that may respond to interrupted treatment with a negative result of therapy and regression of the disease. What to do if, during the height of the drug fight against thrush or trichomonas, the patient began to have monthly bleeding?

In addition, the therapeutic effect of the constituent substance miconazole will also be reduced during this period; the antifungal component interacts with blood fractions and can decompose. At the same time, the medical literature does not describe pathological reactions to the use of the drug “Klion D” during menstruation.

The same can be said regarding the use of the medicine for women “Klion D 100” during menstruation. You should not expect negative reactions to the drug, since this name is simply a brand name for regular vaginal tablets. However, the effect of treatment will be much lower than usual.

Based on all of the above, we can conclude: the use of the drug “Klion D” during menstruation is not dangerous, it’s just that the treatment requirements in this case should be significantly reduced. If possible, the course of therapy with the drug in question should be carried out during the normal period of the woman’s condition, however, sudden monthly bleeding is not an excuse to stop treatment.

We recommend reading the article about the use of suppositories during menstruation. From it you will learn about the features of treatment during menstruation, methods of administering suppositories during menstruation in a woman.

The use of any drugs to combat infections of the female genital area can only be carried out under the supervision of specialists. It is gynecologists and dermatologists who are obliged to educate the patient in all the intricacies of treatment of the identified female genital pathology, give appropriate recommendations, and explain the possibility and problems of undergoing specific therapy on critical days.

Contraindications

Klion-D candles have few restrictions on use. This is due to the fact that they are poorly absorbed into the blood, and their concentration in the body is insignificant.

But it should still not be taken in the following cases:

Pronounced leukopenia.
Acute form of renal or liver failure.
Severe forms of epilepsy, which are accompanied by frequent seizures and convulsions.
Pathological processes leading to disruption of the central nervous system.
The disease results from impaired blood circulation.
Forms of diabetes mellitus at the last stage.
The appearance of an allergy and its symptoms to any ingredients of vaginal suppositories.
It is unacceptable to carry out therapy with these suppositories while simultaneously taking alcohol, since alcohol significantly reduces the effectiveness of using Klion-D.

Side effects of Klion-D

Compared to other drugs of this pharmacological group, Klion-D suppositories are considered low-toxic and cause few side effects.

Sometimes the following symptoms may appear:

The appearance of local discomfort. The patient may experience redness, a feeling of the presence of a foreign body in the vaginal area, the genitals may be very itchy, burning, and swelling of the genitals.
Increased vaginal discharge.
Sometimes severe migraines occur.
On the part of the digestive system , taste disturbances, dryness of the mucous membranes of the oral cavity, nausea, cramping pain in the lower abdomen, increased gas formation, and diarrhea may be observed.
on the skin , and in very severe cases, but extremely rarely, Quincke's edema can develop.
The blood formula and the color of urine may change.

Overdose

When using Klion-D suppositories, the appearance of overdose symptoms is reduced to almost zero.

But if the drug is taken for a very long time, and the patient has a history of allergic reactions, then the body may be poisoned by this medication.

Also, the clinical picture of overdose may appear if additional, oral use of metronidazole occurs in the treatment of pathological conditions.

Patients experience:

Nausea, which is accompanied by vomiting, and a metallic taste appears in the mouth.
There may be pain on palpation of the liver.
In rare cases, seizures and paresthesia may occur.
The most severe manifestation of an overdose is the appearance of Quincke's edema or anaphylactic shock.

At the first signs of an overdose, the patient must:

Rinse the stomach using a sufficient amount of water, at least 2 liters.
Cleanse the intestines. To do this you need to give an enema.
Be sure to take enterosorbent, it can be Polysorb, Enterosgel, Sorbex, white activated carbon.
It is advisable to put the patient to bed and, due to dehydration, give a warming drink.

If the symptoms of an overdose do not disappear, it is advisable to contact a medical facility.

Action with alcohol

This medicine cannot be combined with the use of alcohol.

Alcohol suppresses the effect and positive effect of Klion-D suppositories, and also, in tandem with this medicine, has a negative effect on the liver.

And very often it can cause increased side effects, ultimately serving as a reason to discontinue this medication.

Sometimes, under the influence of alcohol, a patient may experience a disulfiram-like reaction.

It is accompanied by the appearance of acute, paroxysmal pain in the lower abdomen, the occurrence of uncontrollable vomiting, the appearance of headaches, and sudden flushes of heat and blood to the face.

special instructions

To prevent unwanted side effects, you must follow certain rules when using this drug:

If there are clear contraindications, then the use of suppositories is excluded.
Concomitant use with alcoholic beverages is not allowed.
When breastfeeding, young mothers are advised to take a break if this drug is prescribed.
Combining this medicine with antibacterial therapy requires special care to avoid unwanted side effects.
If anticoagulant therapy occurs simultaneously, treatment should be carried out under the supervision of a doctor. This will avoid sudden bleeding.
Be careful when driving vehicles. Since this drug can influence a person’s reaction and behavior in emergency situations.

A good, correct effect from the use of Klion-D suppositories can only be achieved if all the rules and regulations for their use are followed.

Therefore it is necessary:

If treatment is prescribed, the instructions provide for therapy of the sexual partner. Otherwise, re-infection may occur.
During treatment, if work is associated with complex automatic processes, it is better to abstain from it; you must take sick leave for the entire period of treatment.
Having sex during therapy is unacceptable.
It is imperative to monitor, with the help of laboratory tests, the clinical state of the blood (monitor the number of leukocytes and the state of the leukocyte formula).

Interaction

Klion-D suppositories are often used in combination with other medications:

A good effect is observed when they are combined with antibacterial therapy , broad-spectrum antibiotics, and sulfonamides. However, the route of drug administration may be different.
If taken simultaneously with Disulfiram, side effects may occur, which manifests itself in the form of impaired consciousness. There is no compatibility between these drugs.
The use of suppositories is contraindicated in cases of use of muscle relaxants.
Drugs that prevent blood clotting (anticoagulants) can increase the prothrombin index, which provides grounds for reducing their dose.
A group of pharmacological agents that can enhance microsomal oxidation in the liver (finitol, phenobarbital) are not combined with taking Klion-D suppositories, as they help reduce their effectiveness.
Cimetidine can significantly reduce the elimination of metronidazole components, as a result of which this leads to the development of side effects.
Vaginal suppositories Klion-D significantly increase the level of lithium in the blood ; therefore, it is advisable to reduce their dosage or completely eliminate it.
In the case of treatment of pathological processes with these drugs, it is undesirable to concurrently use and use local antiseptics and solutions that are used for douching. This combination of drugs can suppress the positive effects of vaginal suppositories.

During pregnancy and lactation

Klion D is contraindicated for use during pregnancy in the 1st trimester. Sometimes suppositories are prescribed during pregnancy in the 2nd and 3rd trimester, under the supervision of a doctor. Due to the fact that a significant part of metronidazole is excreted in breast milk, breastfeeding should be discontinued.

Treatment with this drug is absolutely contraindicated in the first trimester of pregnancy. This is due to the ability of the active substance to be absorbed into the bloodstream. Metronidazole enters the fetus through the placental barrier, which can cause developmental defects. From 13 to 40 weeks of pregnancy, the drug is prescribed taking into account the excess of benefit for the mother over the possible likelihood of developing pathologies in the fetus.

Analogs

There are a very large number of substitutes for the drug Kliona-D.

They can be conditionally divided according to their chemical composition. That is, have an identical chemical composition, or be based on an ingredient that, in the instructions for use, will be similar in action to candles with Klion-D.

Let's consider several analogues:

Metromicon Neo. Its composition almost completely corresponds to the components of Klion D. It has a wider spectrum of action, as a result of which it can replace the drug Klion D in the treatment of amebiasis and giardiasis, pathological processes that are caused by anaerobic infection.
Vagiferon. This drug has indications similar to Klion-D, but unlike it, it is active against mixed infections, herpes simplex virus, mycoplasma. Contraindications mainly apply to pregnant women and girls under 18 years of age.
Metrovagin. A medication based on metronidazole, with a pronounced antibacterial and antimicrobial effect. The main condition for achieving the full therapeutic effect is use by both sexual partners and complete abstinence from sexual intimacy for the entire period of treatment. The medicine is available only in the form of ointment, helium or vaginal suppositories. Its big disadvantage is its many contraindications.
Vagisept. A good analogue, with a good chemical composition (Fluconazole, Metronidazole).
Genisol. A medicine containing miconazole nitrate (100 mg). Effective against gram-positive microorganisms and fungal infections. Not used in the second and third trimester of pregnancy. Renal failure is a reason to discontinue the drug.
McMiror. It is a good remedy for the treatment of pathologies caused by vaginal trichomonas or candida fungus. Its use is limited only to cases of hypersensitivity. This is the main criterion when the drug is contraindicated. In some cases, instead of suppositories, you can use vaginal cream, which is sold along with a convenient applicator.

Description of effective analogues

Now you know how the drug “Klion-D” affects the body. Instructions, reviews, composition features - this is information that is definitely worth reading. But what should patients do if, for one reason or another, the above-described medicine is not suitable?

In fact, analogues exist. For vaginosis and candidiasis, Gaynomax vaginal suppositories are often used. Drugs such as Metromizol, Neo-Penotran and Metromicon-Neo contain the same active ingredients (metronidazole and miconazole). Of course, it is better to entrust the choice of a substitute to the treating gynecologist. Self-medication always carries risks.

Price

In the pharmacy chain, this medicine has a cost that ranges from 270 to 500 rubles for 10 pieces. Candles are produced in cardboard packaging. They are accompanied by an annotation on the use of this medicine.

Substitutes can be purchased at the following prices:

Neo-Penotran in the amount of 14 candles can be purchased for 930 rubles.
A Metrovagin pack with ten suppositories will cost from 420 to 500 rubles.
Metromicon-Neo. The cardboard packaging contains 2 blisters of 7 pieces. The price of this dosage form does not exceed 450 rubles.

The price in a pharmacy is higher than in an online store.

But this does not mean that when purchasing a medical drug outside a pharmacy network, you will be provided with insurance that will allow you to avoid purchasing a counterfeit.

Therefore, it is recommended to buy medicines only in a pharmacy chain; to confirm their quality when purchasing from a pharmacist, you can ask for a certificate.

Terms of sale

This drug can be purchased at a pharmacy by presenting a prescription, which will indicate the doctor’s name, his signature, and an individual stamp.

You can use the refrigerator to store it, this will avoid compromising its consistency. It should be taken into account that this medicine does not accidentally end up in the hands of children.

Shelf life from the date of release is 5 years.

Requires a prescription.

In a dark, cool place, protected from children, temperature up to 30 degrees.