The main method of treating gynecological diseases is drug therapy. The most popular products are considered to be those that contain more than two components. One of these drugs is Neo-Penotran - suppositories that eliminate inflammation in the vagina. Often, taking medications coincides with critical days, which can significantly affect the effect of treatment. In order to understand whether it is possible to use Neo-Penotran suppositories during menstruation, you should familiarize yourself with its principle of action.
Release form, composition and packaging
Vaginal suppositories | 1 sup. |
active substances: | |
metronidazole | 500 mg |
miconazole nitrate | 100 mg |
excipients: vitepsol S55 - 1900 mg |
Vaginal suppositories.
7 pcs. in a plastic blister made of PVC/PE. 1 or 2 blisters are placed in a cardboard box. Neo-Penotran Forte fights a number of vaginal infections, reliably destroying foci of bacterial invasion. The positive effect of therapy is achieved within several days. The price of Neo-Penotran Forte varies between 750-950 rubles. Reviews about Neo-Penotran Forte are mostly positive. Analogues of Neo-Penotran Forte, like the drug itself, are prescribed by a doctor after determining the type of infection.
The speed and effectiveness of therapy is the drug of choice for the treatment of thrush and a wide range of vaginitis. One Neo-Penotran Forte suppository contains three types of components: • 750 mg of crushed metronidazole; • 200 mg crushed miconazole nitrate; • 1550 mg vitepsol S 55. The suppository is a simple suppository with an oval end.
Admission course
There are two forms of release of the drug. Regular NEO-PENOTRAN contains 100 mg of miconazole and 500 mg of metronidazole. This is the most commonly used option. NEO-PENOTRAN Forte contains 200 mg of miconazole and 750 mg of metronidazole. It is used more often for trichomonas colpitis or concomitant infection.
In any case, the dose and regimen are determined by the doctor after examination and establishment of an accurate diagnosis.
But there are standard prescribing methods. They look like this:
- For uncomplicated infection or preventive sanitation, it is possible to prescribe suppositories one at night for 7 or 14 days.
- In more complex cases, apply one capsule twice a day for a week.
Each suppository is placed deep into the vagina. It is better to do this in a lying position. After administration, you should remain in a horizontal position for 15-20 minutes to prevent the dissolved drug from leaking out of the vagina. For ease of intravaginal use, the kit includes a special finger attachment along with the drug, which can be used if necessary.
Treatment with NEO-PENOTRAN suppositories is often combined with oral administration of antibacterial or other drugs. This enhances the action and effect of the medicine.
Women often worry whether it is possible to insert NEO-PENOTRAN suppositories during menstruation, if the course of treatment fell on these days. If necessary, you can add medicine only on days of minor discharge. If you have heavy menstruation, you should take a break for several days while continuing to take the pills (if they were prescribed).
Pharmacological properties
Thanks to the combination of antiparasitic and antimicrobial active ingredients, Neo Penotran vaginal suppositories are widely used in gynecology. Once in a woman’s body, the drug has an immediate effect, suppressing the reproduction and activity of pathogenic microorganisms. The combination of metronidazole and miconazole nitrate is harmful to the following types of microorganisms:
- Candida;
- Cryptoccocus;
- Aspergillus.
The drug is used to treat thrush during menstruation.
In modern gynecology, Neo-Penotran vaginal suppositories are prescribed by specialists for the treatment of the following diseases:
- Anaerobic vaginosis;
- Trichomonas vulvovaginitis;
- Nonspecific vaginitis;
- Gardnerella vaginitis;
- Colpitis of a trichomodal or candidal nature;
- Mixed type genital tract infections;
- Dysplasia;
- Infectious lesions resulting from cauterization of the cervix.
Some doctors recommend a course of vaginal suppositories as a prophylaxis after surgical operations affecting the organs of the woman’s reproductive system (cleaning, curettage, abortion).
Category ICD-10 | Synonyms of diseases according to ICD-10 |
A59 Trichomoniasis | Acute trichomoniasis |
Recurrent trichomoniasis in women | |
Trichomonas infections | |
Trichomoniasis | |
Chronic complicated multifocal trichomoniasis | |
Chronic trichomoniasis | |
A59.0 Urogenital trichomoniasis | Vaginal trichomoniasis |
Vaginitis due to Trichomonas | |
Trichomonas colpitis | |
Trichomonas genitourinary infection | |
Trichomonas inflammation of the vagina | |
Trichomonas inflammation of the genitourinary tract | |
Trichomonas vaginitis | |
Trichomonas urinary tract infections | |
Trichomonas urethritis | |
Trichomonas balanoposthitis | |
Trichomonas vaginitis | |
Trichomonas vulvovaginitis | |
Trichomonas colpitis | |
Trichomonas urethritis | |
Trichomoniasis of the genitourinary system | |
Urethritis due to Trichomonas | |
Trichomonas urethritis | |
B37.3 Candidiasis of the vulva and vagina (N77.1*) | Vaginal candidiasis |
Vaginal candidiasis | |
Vulval candidiasis | |
Vulvovaginal candidiasis | |
Vulvovaginal candidiasis | |
Vulvovaginitis candidiasis | |
Vulvovaginitis mycotic | |
Fungal vaginitis | |
Vaginal candidiasis | |
Candidiasis of internal organs | |
Genitourinary candidiasis | |
Candidiasis of the genitourinary organs in women | |
Candidiasis with damage to the skin and mucous membranes | |
Candidiasis of the mucous membranes | |
Candidiasis of mucous membranes and skin | |
Candidal vaginitis | |
Candidiasis vulvitis | |
Vulvovaginal candidiasis | |
Colpitis of fungal etiology | |
Vaginal thrush | |
Moniliasis vulvovaginitis | |
Acute vaginal candidiasis | |
Acute mycosis of the vagina | |
Superficial candidiasis of the genital mucosa | |
Recurrent vaginal candidiasis | |
Recurrent vaginal candidiasis | |
Urogenital candidiasis | |
Chronic vaginal candidiasis | |
Chronic candidiasis of the mucous membranes | |
Chronic recurrent vaginal candidiasis | |
N73.9 Inflammatory diseases of the female pelvic organs, unspecified | Abscess of the pelvic organs |
Bacterial diseases of the urogenital tract | |
Bacterial infections of the genitourinary system | |
Bacterial infections of the pelvic organs | |
Intrapelvic infections | |
Inflammation in the area of the cervix | |
Pelvic inflammatory disease | |
Pelvic inflammatory disease | |
Inflammatory gynecological diseases | |
Inflammatory diseases of the female pelvic organs | |
Inflammatory diseases of the pelvic organs | |
Inflammatory diseases of the pelvic organs | |
Inflammatory infections in the pelvic area | |
Inflammatory processes in the pelvis | |
Gynecological infection | |
Gynecological infections | |
Gynecological infectious diseases | |
Purulent-inflammatory diseases of the pelvic organs | |
Infections of female genital organs | |
Infections of the pelvic organs in women | |
Pelvic infections | |
Infections of the urogenital tract | |
Infectious diseases of the reproductive system | |
Infectious diseases of the genital organs | |
Infection of female genital organs | |
Metritis | |
Acute infection of the female genital organs | |
Acute inflammatory disease of the pelvic organs | |
Pelvic infection | |
Tuboovarian inflammation | |
Chlamydial gynecological infections | |
Chronic inflammatory diseases of the pelvic organs | |
Chronic inflammatory diseases of the appendages | |
Chronic infections of the female genital organs | |
N76 Other inflammatory diseases of the vagina and vulva | Bacterial vaginitis |
Bacterial vaginosis | |
Bacterial vaginitis | |
Bacterial vaginosis | |
Vaginitis | |
Bacterial vaginitis | |
Inflammatory diseases of the vagina and vulva | |
Inflammatory diseases of the female genitalia | |
Inflammatory diseases of the female genital organs | |
Vulvitis | |
Vulvovaginal infections | |
Vulvovaginitis | |
Atrophic vulvovaginitis | |
Bacterial vulvovaginitis | |
Estrogen deficiency vulvovaginitis | |
Vulvovaginitis | |
Gardnerellosis | |
Fungal vulvovaginitis in girls and virgins | |
Vaginal infection | |
Genital infection | |
Colpitis | |
Violation of the purity of vaginal secretions | |
Nonspecific cervicovaginitis | |
Nonspecific vulvitis | |
Nonspecific vulvovaginitis | |
Nonspecific colpitis | |
Recurrent nonspecific bacterial vaginosis | |
Senile colpitis | |
Mixed vaginal infections | |
Mixed colpitis | |
Chronic vaginitis | |
N77.1 Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere | Fungal vulvovaginitis in girls and virgins |
Mixed vaginal infection | |
Mixed vaginitis | |
Specific vulvovaginitis | |
Chronic recurrent mycosis of the vagina | |
Cervicovaginitis |
To whom and when is it prescribed?
The range of indications for prescribing suppositories is very wide. This is due to the composition of the drug and its basic properties. There are two forms - regular and extended-release (Forte). The difference is in the amount of active components. You can also find the form of suppositories and vaginal tablets, which has no fundamental difference.
The main active ingredient is metronidazole. Miconazole, an antifungal drug, has also been added. Metronidazole has a detrimental effect on protozoa (amoeba, trichomonas), pathogenic microorganisms in the vagina (gardnerella, streptococcus and others). Moreover, the drug destroys all pathogenic flora, and does not simply inhibit its reproduction. Miconazole is one of the effective fungicidal drugs. Can be used to treat both chronic and acute fungal infections. Remarkably, it even slows down the formation of new pathogenic bacteria.
Thus, the spectrum for prescribing candles:
- candidal colpitis (thrush),
- bacterial vaginosis,
- trichomonas colpitis,
- nonspecific mixed infection in the vagina,
- recovery after cauterization of the cervix,
- sanitation on the eve of surgical interventions (curettage, abortion, abdominal surgery, etc.),
- in the complex treatment of cervical dysplasia.
It is not advisable to use NEO-PENOTRAN during menstruation, as the effect of treatment is reduced several times.
The medicine can be used both during exacerbation of infections and for the treatment of chronic lesions.
The drug can be used in girls over 16 years of age who are sexually active. During pregnancy, the use of NEO-PENOTRAN is prohibited up to the 15th week inclusive, as its components can have a negative effect on the fetus.
And a little about secrets.
Suppositories for thrush "Neo-Penotran" are recommended for use once a day, one suppository at night. As a rule, the duration of the course of therapy is 1 week. In addition, for those who treat relapses of candidiasis or vaginitis (resistant to other types of therapy), this drug is prescribed as a 2-week course of treatment. On an individual basis, to quickly achieve an effect, this medication can be prescribed twice a day, morning and evening, for the 1st week.
- Vulvovaginitis of fungal origin;
- headaches, dizziness;
- Vaginitis of bacterial origin;
Neo-Penotran Forte-L suppositories contain miconazole, which has an antifungal effect, metronidazole, which has an antibacterial and antitrichomoniacal effect, as well as lidocaine, which has a local anesthetic effect.
Dosage
Can I take it during menstruation?
When starting a course of treatment, it is advisable to start taking the drug one and a half to two weeks before menstruation. NEO-PENOTRAN suppositories during menstruation may not have the desired therapeutic effect.
If necessary, you can put the medicine on days of minor discharge. But in no case should you take vaginal tablets or then use several at once to “catch up” with the treatment. As a rule, complex therapy is prescribed for sexually transmitted infections. Therefore, during critical days, it is necessary to stop taking oral medications, and then refill the missed suppositories according to the scheme.
NEO-PENOTRAN is a universal and effective suppository for the treatment of a wide range of sexually transmitted infections. The regimen and indications for prescription should be determined by the doctor. Independent uncontrolled use can lead to adverse reactions and complications, and an acute infection can become chronic. Whether NEO-PENOTRAN can be taken during menstruation or other bleeding (for example, after cauterization of the cervix), as well as other features of administration in a particular situation, can only be determined by a gynecologist.
Source
Indications for the use of suppositories
Neo-Penotran Forte is used only in cases of bacterial and fungal invasions in adult women (over 18 years of age). There are contraindications: 1. Trimester of pregnancy. In the early stages of pregnancy, use caution and only after consulting a doctor. 2. Deviations of a neurotic and neurological nature (porphyria and epilepsy). 3.
Allergy to the components of the medication and excipients in the suppository. 4. Severe liver failure and liver disease. 5. The area of the entire hymen. Clinical trials of the drug in girls under 18 years of age have not been conducted to a sufficient extent to establish the risks of using the drug combination.
vaginal candidiasis;
trichomonas vulvovaginitis;
bacterial vaginosis;
mixed vaginal infection.
porphyria;
epilepsy;
severe liver dysfunction;
pregnancy (first trimester);
age under 18 years (insufficient data on use in this age category);
in virgins.
Keep out of the reach of children.
3 years.
Do not use after the expiration date stated on the package.
Suppositories are used for vaginitis of various etiologies. Indications for prescribing the drug are:
- Candidiasis. A fungal disease, which is also called thrush because of the characteristic discharge.
- Bacterial vaginosis. This pathology is caused by a number of bacteria sensitive to metronidazole.
- Trichomonas vaginitis is a disorder caused by Trichomonas.
- Mixed vaginitis. Pathology resulting from damage by several types of bacteria and fungi.
Neo-Penotran candles
For genital infections, a particularly effective form of release is vaginal suppositories, which act directly on the site of pathology. The medicine Neo-Penotran, produced in the form of suppositories, has proven itself well. The drug is used in gynecology and has pronounced antibacterial, antifungal, and antiprotozoal properties. Vaginal suppositories are not prohibited during pregnancy and lactation, but require medical attention.
It turns out that Neo-Penotran is a combined treatment that can overcome any genital infection and is widely used in modern gynecology. The chemical composition of Neo-Penotran is complemented by a substance called vitepsol, as an auxiliary element to enhance the therapeutic effect and accelerate the natural healing process.
The effect of vaginal suppositories is immediate, but only for medical reasons. It is important not only to remove the signs of the disease, but also to promptly detect their cause. Only in this case, the prescribed dosage as soon as possible allows the patient to experience the long-awaited relief. So, local use of Neo-Penotran is appropriate in the following clinical situations:
When a burning sensation occurs and specific vaginal discharge appears, patients resort to self-medication. Doing this is contraindicated, especially since Neo-Penotran vaginal suppositories have their own contraindications. Before prescribing the specified medication, the doctor conducts a detailed diagnosis. So consultation with a specialist before intravaginal administration of the drug Neo-Penotran is mandatory. Contraindications to the use of these vaginal suppositories are as follows:
- the body's sensitivity to synthetic components of suppositories;
- extensive damage to the central nervous system;
- pregnancy in the first trimester;
- porphyria;
- liver dysfunction;
- epilepsy;
- age restrictions up to 14 years;
- lactation period;
- hematopoiesis disorders;
- in combination with alcohol;
- virginity.
For genital infections, it is better to use vaginal suppositories rather than taking pills. This form of drug release demonstrates fewer side effects in the body and has a limited list of contraindications. The final word belongs to the attending physician. Side effects of Neo-Penotran are reflected in the instructions, but in reality they are represented by the following anomalies that arise at the very beginning of the treatment course:
- from the gastrointestinal tract: severe signs of dyspepsia, dry mouth, lack of appetite, nausea, vomiting;
- from the skin: irritation and redness of the vaginal mucosa, itching and burning, discomfort;
- from the central nervous system: migraine attacks, irritability, peripheral edema, dizziness, ataxia, convulsions;
- from the hematopoietic organs: leukopenia;
- from the skin: allergic, local reactions on the upper layer of the epidermis.
Before purchasing an antibiotic or antifungal agent, consult a specialist. You can choose from the catalog, order and buy Neo-Penotran suppositories for thrush in the online store, but their action is not always reliable and effective. This is a consequence of superficial self-medication. In fact, some people are more suitable for Neo-Penotran analogues with identical pharmacological effects in the body. Doctors place special emphasis on the effectiveness of the following medications:
- Klion-D 100;
- Clomesol;
- Clotrimazole;
- Metromicon-Neo;
- Ketonazole;
- Livarol;
- Clevazol;
- Metrogyl Vaginal;
- Mycogal;
- Ginalgin;
- Kandisan;
- Gynofort (cream);
- Candibene (cream);
- Gravagin;
- Econazole;
- Trichopolum;
- Pulsitex.
Candidiasis is diagnosed in almost all expectant mothers, but they are treated with special caution, trying to limit the fetus as much as possible from the influence of antifungals. The prescription depends on a number of factors, but when choosing a drug, the duration of pregnancy must be taken into account.
Since we are looking for an answer to the question of which suppositories for thrush are effective during pregnancy, and not just approved ones, we focus specifically on this parameter.
Much more suffering people in the reviews praise Ginezol 7 (miconazole). Suppositories quickly relieve unpleasant itching, burning and other symptoms, but they are prescribed as a weekly course. In addition, the instructions include the 1st trimester of pregnancy in the list of contraindications.
In conclusion, we note that do not take risks by independently choosing effective suppositories for thrush based on the advice. Reviews, past experiences and advertising slogans are not suitable guides when it comes to health.
Candidiasis is quite common in pregnant women. Treatment must be carried out not only to cure the expectant mother, but also to prevent the child from becoming infected when
it will pass through the birth canal. The safest remedy for treating thrush in pregnant women is vaginal suppositories
, which is part of this drug, has almost no contraindications and is non-toxic to the fetus.
Pregnant women often experience decreased general and local immunity. The consequence of this is thrush. During pregnancy, it is difficult to choose a safe drug to treat candidiasis, since many antifungal agents do not have safety data.
Approved suppositories for pregnant women:
- Suppositories with the active ingredient Natamycin (Pimafucin, Primafungin).
- A combined drug with the active ingredients Nystatin and Nifuratel - Macmiror complex;
- Preparations for use exclusively in the 2-3 trimester of pregnancy - Nystatin, Clortrimazole, Pimafucin, Gyno-Pevaril, vaginal cream Ginofort, the time-tested remedy Borax in glycerin (sodium tetraborate in glycerin). Medicines are used with extreme caution if the risk to the health of the fetus does not outweigh the risk to the health of the mother.
- When your doctor prescribes Terzhinan in the 2nd-3rd trimester of pregnancy, you should take into account that it contains the hormonal drug Prednisolone, and can be used in cases where the health of the mother is at greater risk than the health of the child.
Very often, thrush occurs in women during pregnancy due to a physiological decrease in immunity, and many drugs either categorically cannot be used, or reliable studies of safety for the fetus have not been carried out.
- Suppositories - Pimafucin, Primafungin (active ingredient Natamycin).
- Combined drug - Macmiror complex (active ingredients Nystatin and Nifuratel).
- In the 2-3 trimesters Clotrimazole, Nystatin (low effectiveness) or the ancient remedy Borax in glycerin (Sodium tetraborate in glycerin), Pimafucin, Gino-Pevaril, Ginofort (vaginal cream), all these drugs are used during pregnancy with caution if there is a potential risk for the health of the mother exceeds the risk for the child.
- Some doctors prescribe a combination drug - Terzhinan (prednisolone, neomycin, ternidazole, nystatin), but the instructions for it indicate that from the 2nd trimester it can only be used when assessing the potential benefit to the mother and harm to the fetus, since it has undesirable side effects and contains a hormonal drug - prednisolone.
In the early stages of pregnancy and if side effects from the drug occur, it should be replaced with a safe analogue. Antimicrobial and antifungal suppositories allowed for expectant mothers include:
- Suppositories “Betadine”. The drug has an antimicrobial and antifungal effect and is prohibited in the 2nd and 3rd trimesters.
- Suppositories “Clotrimazole”. Antifungal agent. Prohibited in the 1st trimester.
- Metromicon-Neo. It has mixed antimicrobial and antifungal effects. Cannot be used in early pregnancy.
- Lomexin. Suppositories effective in the treatment of vaginal candidiasis. Contraindicated in the first weeks of pregnancy.
- Livarol. Suppositories suppress the growth of fungi, destroy steptococci and staphylococci. In the early stages of pregnancy, the drug is prohibited; in the 2nd and 3rd trimesters it is used with caution.
How to use during menstruation
Most experts believe that the effect of some drugs decreases during menstruation. In some people this deficiency is mild, in others it is more pronounced. The problem is also typical for this drug. At the same time, it is not always possible to refuse to use Neo-Penotran vaginal suppositories during menstrual periods, since in this case we are talking about a course of treatment, which is strictly not recommended to be interrupted.
It is known that the active substances of the drug enter the bloodstream through vaginal absorption. Considering the fact that during menstruation, local blood circulation is significantly more intense, absorption occurs faster - this is an advantage. But we must take into account the fact that the body is weakened at this time, the hormonal levels are changed, and its protective mechanisms are reduced. Therefore, you need to place Neo-Penotran suppositories during menstruation carefully, carefully monitoring the slightest changes in the state of your own body.
It is important to know
Treatment of an infectious disease in the vagina involves following the following rules:
- Limit sexual contacts. An intimate relationship can trigger a relapse of the disease if the sexual partner is also infected. In addition, the active components contained in suppositories can damage the condom.
- Refusal of drinking alcoholic beverages. Combining alcohol and drugs can cause mental illness.
- Under no circumstances should Neo-Penotran suppositories be used orally. If you try to take it orally, you should immediately induce vomiting and go to a medical facility, where doctors will perform gastric lavage. Use suppositories for their intended purpose.
- Diseases of the nervous system and liver can aggravate the effectiveness of therapy. But if necessary, the drug can be used only after the approval of the attending physician.
Neo-Penotran is an effective remedy that is used in the treatment of sexually transmitted infections. When used correctly, suppositories have a positive effect on the vaginal microflora. If the instructions for use are not followed, the drug can cause serious complications.
Side effects and combination with alcohol
As mentioned earlier, most often Penotran is well tolerated; numerous trials of the drug have shown that it causes almost no adverse reactions. Sometimes there may be irritation in the vaginal area. If you notice such a symptom in yourself, and it lasts more than three days, you need to interrupt the course of therapy and consult a doctor so that he can change the drug to one that is suitable for you.
- Bad mood;
- prolonged diarrhea;
- rash all over the body;
- constipation;
- pain in the genital area;
- vomit;
- muscle weakness;
- headache;
- excessive fatigue;
- dry mouth.
All these side effects are inherent in this medicine, but most often they do not occur at all, patient reviews have confirmed this. I would like to note that pregnant women cannot use Neo Forte suppositories in the first trimester. After this period of time, they can be used as usual for the rest of the pregnancy.
Important information! People with severe diseases of the central nervous system and liver should not take Penotran. It is recommended not to have sexual intercourse until the end of the entire course of therapy, since the likelihood of infecting your sexual partner is very high. He also needs to undergo treatment with the drug only orally. I would like to note that you can drink alcohol during the period of using Penotran three days after taking the medication.
Neo Forte suppositories should not be used for therapy in virgins and very young girls. Neo Forte candles can be used by women when driving; they are absolutely not dangerous. Penotran is not recommended to be taken simultaneously with other medications, as it can greatly distort the reaction of another medication or make it completely ineffective. The product should be stored in a dark place, away from children.
When this drug is used simultaneously with alcohol, a so-called disulfiram reaction may occur. With the simultaneous use of metronidazole, certain disturbances in the central nervous system may occur. Also, this medication, together with alcohol, can increase the toxicity of lithium. With a single dose of alcohol and metronidazole, the level of phenytoin in the blood itself decreases.
You can still talk about this topic for a very long time, but patient reviews have long proven that alcohol and medicine cannot be taken at the same time, and this applies not only to this drug. Any medicine can cause a lot of side effects when combined with alcohol. You need to know this and follow the rules.
When the drug Penotran penetrates into the human body, the active substances begin to suppress bad microflora. Thanks to the good combination of substances that make up the medicine, there are practically no relapses of infections, and this is confirmed by reviews of people who were once treated with this remedy.
Metronidazole prevents the production of nucleic acid, which leads to the death of microbes. Among other things, Penotran destroys almost any infectious agents.
Due to the fact that metronidazole passes directly into the bloodstream, its concentration in the human body is the same throughout the treatment. Penotran is a powerful antifungal medication that completely destroys the membrane of harmful cells and does not allow them to recover. In addition to all of the above, the drug does not allow the development of gram-positive microbes.
You should also not have sex during the entire period of therapy, as this can lead to complications of the disease.
When treating cervical erosion, whitish discharge may appear; this is an absolutely normal situation, but if the discharge becomes bloody, you must immediately consult your doctor and undergo a full examination. After receiving the tests, the doctor will prescribe the appropriate medication, which will definitely help you.
- Treatment of bacterial vulvovaginitis.
- Trichomonas.
- Thrush.
- Infection of several pathogens at once.
- Allergic reaction to components.
- First trimester of pregnancy.
- Epilepsy.
- Liver disorders.
- Lactation.
- Childhood.
- Disorders in the central nervous system.
- Incorrect plasma production.
Contraindications
NEO-PENOTRAN is absorbed from the vaginal mucosa into the systemic circulation. The drug is metabolized in the liver. This determines some restrictions in its use. These include:
- Allergic reactions to any component of the drug individually or unsuccessful attempts to use NEO-PENOTRAN earlier.
- Women with chronic liver pathology should take it with caution, especially when taking several medications simultaneously, which increases the load on the organ.
- The drug should not be used during breastfeeding and in the first trimester of pregnancy due to possible exposure to the baby. If it is absolutely necessary to use the drug during lactation, human milk should be excluded from the child’s diet for the entire duration of use and for two more days after completion of the course.
- If the use of NEO-PENOTRAN and a missed period suddenly coincide, you should immediately take a pregnancy test. If the latter is confirmed, you should stop taking it and consult a doctor.
- NEO-PENOTRAN should not be used by women suffering from epilepsy, as well as those who have ever had even single convulsive seizures.
- With long-term use, metronidazole can affect blood composition. Therefore, if pathology is present, use should be postponed until recovery or replaced with another drug.
- It is not recommended to use NEO-PENOTRAN in children under 16 years of age.
Metronidazole is a drug used to treat thrush
Thrush torments women; drugs have been developed against it, one of which is metronidazole. Metronidazole treats thrush as a nonspecific remedy.
Vaginal suppositories with Metronidazole
Metronidazole, entering the body, has the following effects:
- antibacterial;
- antifungal;
- antiprotozoal;
- trichomonas;
- antiulcer;
- anti-alcohol.
Thrush can be provoked by several types of pathogens; metronidazole is a drug with a broad spectrum of action against anaerobic bacteria, fungi, and some protozoa, and therefore is often an effective remedy in its treatment. The drug is powerless against aerobic bacteria. The active substance treats by disrupting the respiratory processes in microbial cells or suppressing DNA synthesis, causing cell death.
A wide range of effects determines the use of the drug for diseases affecting different organ systems: from digestive to genital. The drug can be used for candidiasis of the genital organs and oral cavity.
The drug is available in the form of suppositories, and therefore can only be used to treat thrush in women.
Reviews about this drug are mostly positive. Women who used Neo-Penotran are satisfied with the results of the treatment.
Based on patient feedback, there have been no reports of overdose with Neo-Penotran when administered intravaginally. However, in a situation of overdose, the patient may develop nausea, vomiting, diarrhea, the appearance of neurological symptoms, as well as rare seizures. In such a situation, it is first recommended to rinse the stomach and give enterosorbents (Sorbex, Enterosgel, activated carbon). Subsequent therapy is symptomatic, aimed at eliminating pathological symptoms.
If the menstrual cycle is irregular, then a delay in menstruation should alert you. A special test should be performed. During pregnancy, you need to stop treatment and immediately consult a gynecologist.
In men, candidiasis affects the skin of the glans penis and foreskin. Manifested by symptoms such as:
- Redness and swelling of the head.
- A cheesy coating that appears on the head.
- Pain during sexual intercourse, itching sensation.
However, thrush is rare in men because the fungi
do not linger on the male genital organs. Candida is simply washed out of the urethra with urine. Therefore, if a man does get candidiasis, this indicates a greatly reduced immune system that is unable to protect the body from infection.
Vaginal suppositories or tablets from different manufacturers use different active substances to treat thrush. They also differ in cost and are effective at different stages of the disease.
Overdose
Excessive use of drugs leads to systemic negative effects. Overdoses occur due to the increased bioavailability of the active substances in the drug. There is no specific treatment. To neutralize systemic effects, gastric lavage is done (if the drug is ingested or severe poisoning), and then maintenance therapy is prescribed.
There are no data regarding overdose in humans with intravaginal use of metronidazole. However, when administered into the vagina, metronidazole may be absorbed in quantities sufficient to cause systemic effects.
Treatment: if a large number of suppositories are accidentally ingested, gastric lavage can be performed. Improvement in the condition after this can be achieved in persons who have taken up to 12 g of metronidazole orally. There is no special antidote. Symptomatic and supportive therapy is recommended.
Neo-Penotran - instructions
If the side effects of Neo-Penotran do not stop, it is recommended to discontinue the use of vaginal suppositories and choose an analogue. However, in most cases, such anomalies are temporary and disappear after 2-3 days without additional discontinuation of the medication. The Neo-Penotran instructions tell you how to use the suppositories, in what doses, for how long, but are not a guide to use.
When carrying a fetus, use suppositories only as prescribed by a gynecologist. In the first trimester of pregnancy, the drug Neo-Penotran is contraindicated; in the second and third trimester, it is allowed if there is no threat to intrauterine development. Doses are determined individually and administered vaginally. Neo-Penotran forte during pregnancy successfully removes the symptoms of thrush and reduces the activity of other sexually transmitted infections.
If a doctor prescribes such vaginal suppositories during lactation, breastfeeding should be replaced with artificial one. This is a mandatory safety condition for the health of the newborn. The restriction is temporary, and it is allowed to return the child to breastfeeding only 24-48 hours after the cessation of intensive therapy with this antibacterial agent.
The opinions of experts on this topic are very contradictory. Neo-Penotran vaginal suppositories are not prohibited for use during menstruation, but doctors still recommend that their patients wait until vaginal discharge stops and start the course. If menstruation appears during intensive therapy, do not stop using these suppositories. It is better to talk to a specialist about Neo-Penotran and menstruation.
neo-penotran for menstruation
Dear girls, who faced the examination before planning, help me not to give up. My story is like this. My husband and I have been planning a child for over a year now. At first they somehow didn’t attach much importance to this, they lived as they lived and simply stopped taking precautions. I never had any problems with my health in terms of gynecology, I went to the gynecologist as planned every six months, everything was fine. But then a year passed and we started thinking about planning more seriously, and decided to go and get tested at the Center for Sevastopol. Let's go to hear “you guys are an absolutely healthy couple. just don’t push yourself psychologically and everything will work out for you!” And from that moment it began... I was prescribed analysis after analysis, gamons, ultrasound, smears, an endless cycle! My husband was only prescribed a spermogram (we still thought that there might be problems on his part, but the result turned out to be very good - 80% alive). And so, when I passed everything that was possible, the gynecologist gave a verdict - that everything was fine with me, except for the candida and ureaplasma and mycoplasma found in me (less than 10 to the 4th degree, which is considered normal). I didn’t have any manifestations of thrush (candidiasis) at that time, and even the doctor herself was surprised and threw up her hands: “during the examination, I didn’t notice any signs of you!” But at the same time, she prescribed me armor-piercing treatment - Diflucan, Candinorm and Neo-Penotran, all this had to be started from the first days of MC. She told me to retake the test for ureaplasma and mycoplasma again on the last day of the MC. And then my period came and I started treatment (though I still didn’t understand why, because I didn’t feel the symptoms of thrush, not even a hint). on the first day I took Diflucan, on the last day I had a repeat test for ureaplasma and mycoplasia, and continued treatment with Candinorm (it was second in line). And then a severe thrush began! I was shocked. On the third day of candinorma everything only got worse. Next came an analysis for ureaplasma and mycoplasma, it showed that no growth was detected. I was left completely bewildered... I began to doubt that my tests could have been mixed up, and even now I have thrush, which is not treated with the prescribed medications, but is only getting worse. After consulting with my husband, I decided to go to another clinic and listen to another doctor’s opinion about my tests. During the examination, she confirmed thrush and prescribed treatment. Moreover, I saw papillomas that I didn’t even know what they were. My husband has nothing like this, the doctor said that this virus may not affect him if he has a strong immune system. And the doctor also told me to cauterize these papillomas, otherwise during pregnancy everything might get worse and I might even be forbidden to give birth in the usual way, so as not to infect the child. In general, girls, I’m in such a devastated state right now. Just 1.5 months ago I felt like a healthy person, but now I’m some kind of virus carrier. With my low self-esteem I feel like I'm below par. I did not try to attack the doctors with this story. I just want to understand, has anyone encountered a similar situation? How did it all end? For your advice, maybe I should go to the residential complex at my place of residence (I’m already imagining money being siphoned off by previous clinics)? And I also want to thank in absentia all the girls of this forum for your recordings, transcripts and discussion of analyses, advice and support. Without you it would be very difficult!
Manufacturer
This drug contains 2 medicinal substances - metronidazole and miconazole.
Allergic reactions to the drug Neo Penotran: rashes on the skin, severe itching.
Before using Neo Penotran, read the instructions carefully. In case of an overdose of the drug, symptoms such as nausea, vomiting, severe abdominal pain, intestinal upset, itching, dizziness, convulsions, and dark urine may occur.
special instructions
Suppositories damage the integrity of contraceptives. Do not use suppositories if you are planning sexual activity. The patient's sexual partner should undergo treatment for trichomonas infections together with the woman. Under no circumstances should candles be swallowed or used for other purposes! The use of suppositories potentially interferes with the results of blood tests and other laboratory tests of tissues and body fluids. The drug does not affect the ability to work with industrial equipment or drive a machine.
Preclinical data indicate no specific risk to humans based on standard safety, pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and reproductive toxicity studies.
Alcohol intake should be avoided during treatment and for at least 24–48 hours after completion of the course due to possible disulfiram-like reactions.
Caution should be exercised when using suppositories simultaneously with contraceptive diaphragms and condoms due to possible damage to the rubber base of the suppositories.
The drug should not be swallowed or used in any other way than recommended.
Laboratory tests
The results may change when determining the level of liver enzymes, glucose (hexokinase method), theophylline and procainamide in the blood.
Impact on the ability to drive a car and equipment. Does not affect.
Side effects
The negative effects of drugs appear in a mild form. Side effects are conventionally divided into several categories: 1. Allergies. The appearance of a rash in the vaginal area, pain in the lower abdomen and irritation of the mucous membranes. Migraines and headaches occur less frequently. 2. Reactions to the drug. Miconazole irritates the vaginal walls, causing severe discomfort.
In rare cases, hypersensitivity reactions (skin rash) and side effects such as abdominal pain, headache, vaginal itching, burning and vaginal irritation may occur.
Due to inflammation of the vaginal mucosa during vaginitis, vaginal irritation (burning, itching) may intensify after the introduction of the first suppository or by the 3rd day of treatment. These complications disappear quickly as treatment continues. If severe irritation occurs, treatment should be discontinued.
Systemic side effects are very rare because plasma levels of metronidazole are very low following vaginal absorption.
Side effects associated with systemic absorption of metronidazole include: leukopenia, ataxia, mental changes (anxiety, mood lability), convulsions; rarely - hypersensitivity reactions, diarrhea, dizziness, headache, loss of appetite, nausea, vomiting, abdominal pain or cramps, changes in taste, constipation, dry mouth, metallic taste, increased fatigue.
Characteristics of the drug
Cleanliness and sex with a regular partner cannot always protect the female body from vaginal infections. Sometimes just going to the pool is enough to catch a serious sore. Already the first symptoms of the disease (itching, frequent urination, pain) create internal discomfort and reduce the quality of life. If the disease is neglected, complications appear that lead to serious health problems. Therefore, treatment should be started as soon as possible.
One of the drugs that copes well with vaginal infections is Neo-Penotran. It helps well in treating advanced cases of inflammation of the vaginal mucosa, vaginal infections, thrush and other fungal infections. The candles owe their effectiveness to a successful combination:
- micronized metronidazole – antimicrobial and antiprotozoal (destroys protozoan microorganisms) drug;
- micronized miconazole nitrate, an imidazole derivative, the action of which is aimed at combating fungal infections and certain types of gram-positive microorganisms;
- lidocaine – analgesic effect.
The first drug is effective against most bacteria that cause vaginal infections, while the action of the second is directed against fungi of the Candida group, aspergillus, and cryptococcus. Suppositories are inserted into the vagina once a day, the course lasts a week. In case of relapse, repeated treatment is increased to two weeks.
There is no clear opinion regarding the use of the drug during menstruation. Some doctors say that the course must be interrupted and continued after the end of menstruation, others say that treatment cannot be interrupted, and only use pads and tampons are prohibited. It is best to discuss this controversial issue with your doctor, but keep in mind that most of the drug may come out along with the discharge.
Under no circumstances should you self-prescribe the drug or increase the dosage or course of treatment at your own discretion. This can lead to various side effects in the body.
Neo-Penotran during menstruation for the treatment of vaginal infections
Medicines for menstruation
17.01.2018
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4 min.
Violation of the optimal vaginal microbiocenosis (dysbiosis) in women can be accompanied by an inflammatory reaction (various vaginitis) or occur without it.
Of all vaginal infections, bacterial vaginosis, candidiasis (thrush) and trichomonas vaginitis predominate; nonspecific or aerobic inflammation occurs.
Several types of microorganisms are involved in the pathological process of many of these diseases.
Therefore, it is more rational to carry out treatment with complex drugs that combine two or more medicinal substances that are harmful to various microbes.
The priority will be local therapy - suppositories.
Neo-Penotran meets these requirements: it contains metronidazole (effective against most pathogenic vaginal bacteria) and miconazole (active against fungus).
Each suppository of the drug includes: metronidazole 500 mg and miconazole 100 mg. Composition of the drug Neo-Penotran forte: metronidazole 750 mg, miconazole 200 mg.
The action of metronidazole is mainly directed against anaerobic bacteria, including Gardnerella vaginalis, and neutralizes Trichomonas vaginalis. A wide spectrum of activity is observed in miconazole: pathogenic fungi, the most common Candida gram-positive microorganisms.
Indications for use of the drug:
- bacterial vaginosis;
- anaerobic, nonspecific vaginitis;
- trichomonas colpitis;
- vaginal candidiasis (thrush);
- prevention of postoperative complications, preparation for planned gynecological procedures.
Menstruation is not a contraindication for the use of Neo-Penotran.
Treatment time should be adjusted to the menstrual cycle. It is advisable that it does not fall during the period itself. But if it turns out that the use of suppositories overlaps the time of menstrual flow, then the use of Neo-Penotran during menstruation should be continued.
During this period, the mucous membrane of the vagina and uterine cavity becomes even more defenseless against infection - which is why local antibacterial therapy should not be interrupted. Stopping will entail the development of resistance of microorganisms to Neo-Penotran and increased growth of pathogenic microflora. In this case, it will not be possible to achieve positive results.
Bloody discharge does not always signal the onset of your next period. Bleeding may be associated with a short-term pregnancy that has not yet been diagnosed.
Therefore, women who have regular sexual activity without protection are recommended to conduct a pregnancy test before treatment with metronidazole-containing medications (such as Neo-Penotran).
Metronidazole, even when applied topically, in the early stages of gestation can cause disturbances in the development of the internal organs of the fetus. If the test is positive, it is better not to take the drug and choose less aggressive drugs. If the result is negative, therapy can begin.
They are not a contraindication to the administration of lochia suppositories (menstrual-like discharge in the postpartum period).
If during this period a woman develops microflora disorders that are treated with Neo-Penotran, then, despite lochia, as well as menstruation, the drug should be used.
But during treatment you need to express yourself, since metronidazole passes into breast milk in small quantities. You can resume lactation after 2 days.
The medicine should be used exclusively topically - in the vagina.
Dosage of the drug 500 mg metronidazole/100 mg miconazole: 1 suppository 2 times a day every 12 hours (morning and evening) for a week in a row. The course can be extended to 2 weeks for resistant vaginitis and their relapses.
Dosage 750/200 mg: if the amount of active substance is increased, it is enough to put 1 suppository in the evening for 7 days. Treatment time can be extended up to 2 weeks for the same reasons.
The suppositories should be inserted into the vagina as deeply as possible in a lying position with the legs brought as far as possible to the stomach. Before doing this, you should put on a special disposable fingertip, 7 pieces are contained in the package.
Fingertip included with the drug
Before inserting the suppository, you should thoroughly wash your hands and/or treat with an antiseptic. Suppositories are administered at night, after which you should try not to get up until the morning.
This is necessary so that the active medicinal substance remains in the vagina for as long as possible. The fact is that candles have the ability, under the influence of body temperature, to turn into a liquid state and flow out if a person is in an upright position.
That is why the advantage remains with therapy using 1 suppository per day, in which the required effective dosage is observed, that is, Neo-Penotran forte is used.
If candles are placed 2 times a day: one in the evening, the second in the morning, then you need to lie down for a while (30-60 minutes) and use panty liners, because the melted candle will leak out.
During the period of therapy and two days after it, it is not recommended to drink alcohol, as there is a possibility of disulfiram-like reactions: nausea, vomiting, impaired consciousness while drinking alcohol.
You should not have sex while using candles. The partner is also a carrier of the infection and needs to undergo treatment.
During the period of therapy, both men and women eliminate microorganisms differently, and during sexual intercourse, undead strains can be introduced. Protected sexual intercourse will not solve problems.
The components that are used to make suppositories can damage the rubber of the condom and contraceptive diaphragms.
Source: https://fraumed.net/menstruation/medications-menstruation/neo-penotran-vo-vremya-mesyachnyx.html