Duphaston for adenomyosis: how to take, description, side effects

Adenomyosis is one of the forms of such a disease of the female reproductive system as endometriosis. These diseases are characterized by pathological growth of endometrial tissue beyond its normal location. With adenomyosis, the endometrium penetrates into the deep layers of the uterus, which leads to disturbances in the woman’s reproductive system. Various medications are used to treat this disease, and Duphaston for adenomyosis is one of them.

Description of the drug

Duphaston is a hormonal tablet that is an analogue of the hormone progesterone. It is prescribed for a deficiency of progesterone levels in a woman’s body and for pathological disorders associated with this phenomenon.

The main component of the drug Duphaston is a substance called Dydrogesterone.

Excipients included in the medicinal product are:

polyethylene glycol;
corn starch;
titanium dioxide;
hypromellose;
magnesium stearate;
colloidal sodium dioxide;
lactose monohydrate.

Depending on the severity of the disease, Duphaston can be used as an independent drug or in combination with other drugs.

Description of the medicine

Duphaston contains the main substance dydrogesterone - this is a synthetic analogue of the hormone progesterone, it belongs to the group of progestogens . Progesterone is a very important sex hormone; pregnancy will not occur if it does not prepare the uterus for embryo implantation. Under the influence of progesterone, the endometrium is transformed in order to accept a fertilized egg; at the onset of menstruation, progesterone levels rapidly drop.

When prescribing therapy and treating uterine adenomyosis with duphaston, a natural question may arise about the level of progesterone and its effect on the development of the disease, but with adenomyosis the level of this hormone does not always differ from normal levels. Why increase it with the help of duphaston?

The fact is that the cause of adenomyosis is a violation of the normal rejection of endometrial cells during menstruation; instead, endometrial cells penetrate into the muscular layer of the uterus.

Before ovulation, the endometrium grows under the influence of estrogen, and after ovulation, progesterone suppresses its activity and ensures secretory changes in it. Taking Duphaston promotes increased suppression of estrogen activity - this, in turn, leads to the occurrence of atrophic processes during endometrial growth.

Obvious advantages of Duphaston:

There are no unwanted side effects typical of other hormonal drugs.
Affordability, because treatment of adenomyosis with gonadotropin-releasing hormone agonists is very expensive.
This medicine is widely used if a blood test reveals a lack of progesterone; in its pharmacological properties it is close to the natural hormone, so it can quickly restore the balance.
Blood clotting and other indicators do not change.
The medicine is widely used to increase the level of progesterone, which is not enough to conceive a baby and carry a pregnancy to term.
There is no suppression of ovulation or disruption of menstruation, so it is possible to conceive a baby while taking the drug.
Stabilizes the menstrual cycle and reduces pain associated with adenomyosis and other pathologies.

Separately, I would like to note that adenomyosis often causes infertility, so women take duphaston in the hope of getting pregnant, this is possible, but if this happens, you should not abruptly stop the drug, because abrupt withdrawal may result in a miscarriage.

Efficacy in adenomyosis

According to doctors, Duphaston is one of the most effective drugs in the treatment of pathologies of the female reproductive system.

However, it is important to remember that this drug is prescribed by gynecologists only in the initial stages of adenomyosis. Advanced stages of the pathology cannot be treated, since damage to the uterus occurs much faster than the drug begins to act.

If the disease is already advanced and its treatment may require more drastic methods, then Duphaston can be used as an additional medicine.

When endometriosis cannot be treated with duphaston

If adenomyosis of a diffuse, nodular, mixed form has the 3rd and 4th degree of the disease, then surgical treatment is recommended, because when adenomyosis just begins to develop, the symptoms are less pronounced and do not worsen the life of patients; as the disease progresses, severe anemia, pain, bleeding occurs, which threaten life.

For adenomyosis of the 3rd and 4th degrees, as a rule, radical operations are performed, but the ovaries, if there are no indications, are not removed.

If endometriosis is external (ovarian endometriosis), laparoscopy is performed.

Adenomyosis is internal endometriosis because it develops inside the uterus; external endometriosis is considered if the process occurs outside the uterus.

It is important to understand that endometriosis is a chronic disease that has a tendency to relapse; signs of disease development indicate independent growth of the implant. No hormonal treatment changes the cellular mechanisms that lead to the formation of endometriosis. Hormonal therapy affects indirectly, interfering with known physiological processes, treatment consists of influencing estrogens, as the main producers of endometrioid formations, their concentration decreases, endometrial production decreases and frequent relapses of endometriosis disappear.

It is important not to exceed the threshold concentration of estrogen in the blood, because treatment with hormones can lead to hypoestrogenism (lack of estrogen), and this, in turn, leads to bad consequences (early menopause, infertility, etc.).

It has been established that a level of 30–60 pc/ml in the blood does not cause hypoestrogenism and that estrogen is not enough for strong growth of the endometrium.

Operating principle

When taking Duphaston, the female body has the following effects:

the body is saturated with progesterone;
the work of the center, which is responsible for thermoregulation, improves;
epithelial cells stop growing;
the general condition of the uterus improves.

When using a drug to treat adenomyosis in a woman, the following occurs:

hormonal levels return to normal;
pain in the lower abdomen is relieved;
the menstrual cycle is completely restored.

How to use

In complex therapy of adenomyosis, the doctor must take into account the fact that Duphaston may not interact with all medications. Therefore, when prescribing this drug, a woman must strictly follow the prescribed dosage.

In no case should you suddenly stop taking it, except for the moment when a woman realizes that she is pregnant. In this situation, it is necessary to consult with your doctor about how to stop taking Duphaston gradually and not cause harm to the body.

However, in most cases, the doctor recommends that the woman continue taking the drug until the end of pregnancy in order to prevent miscarriage or any other complications that may arise due to the disease.

In order to achieve a positive effect in the treatment of adenomyosis, it is necessary to take the tablets strictly according to the prescribed regimen and not deviate from it.

You need to take the pills at the same time every day. In order not to forget about taking your medication, you need to associate it with some daily household activities, for example, brushing your teeth.

The drug should be taken strictly from days 5 to 25 of the menstrual cycle. During menstruation, you cannot drink Duphaston because, along with bloody discharge, the endometrium comes out of the uterus, which has exfoliated.

Depending on the severity of the pathology, the drug is taken for a year or more. The effectiveness of Duphaston is checked through transvaginal ultrasound. An excellent indicator of a good result is the patient's pregnancy.

Contraindications and side effects

Duphaston has a number of contraindications, and therefore the doctor must conduct a thorough examination of the patient before prescribing this drug to the patient.

Contraindications to taking Duphaston are the following:

liver diseases occurring in acute and chronic forms, which can be either acquired or hereditary;
the patient has a pathology such as Dubin-Johnson syndrome;
lactation period;
allergic reactions due to the fact that the patient may have an individual intolerance to the components that make up Duphaston.

The main consequences that may occur when taking Duphaston are:

the development of an allergic reaction, which is usually manifested by skin rashes or redness of the skin;
bronchospasm;
hives;
shortness of breath that occurs even with the slightest physical exertion;
bleeding, in most cases quite minor. Usually, in this case, the doctor may prescribe a slightly increased dosage of the drug.

Causes of the disease

Provoking factors include:

frequent stress leading to emotional overstrain;
overly active lifestyle;
genetic predisposition;
prolonged sun exposure, frequent visits to the solarium;
surgical manipulations on the uterus (abortion, mechanical trauma, curettage).

To make a conclusion, the doctor uses several methods:

gynecological examination with speculum;
colposcopy;
microflora smears;
Ultrasound of the pelvis;
laparoscopy and hysteroscopy;
general studies of the circulatory, respiratory, digestive and urinary systems.

To exclude the presence of contraindications to a number of medications, consultation with a therapist, hematologist, gastroenterologist and endocrinologist is necessary.

Patient reviews

Below are reviews from women about the treatment of uterine adenomyosis with Duphaston:

By the way, about radon. A friend of mine has been suffering from this adenomyosis since she was 30 years old, now she is 51. She went to radon baths regularly for 10 years in a row. And still she did not avoid cleansing and takes hormones. This is a fact. Maybe radon somehow slows down the development of the disease?

Good evening. I have the same problem - adenomyosis, which I have been suffering from for 13 years, after the birth of my first child, at first I was diagnosed with endometriosis under? I did not receive any specific treatment, sometimes in small courses of COCs. After 9 years I gave birth to my second child, although there were problems with carrying the pregnancy , I carried it only on Duphaston. After the birth of the child, I was diagnosed with adenomyosis. I tried everything to be treated with Duphaston and other hormones, now I take Jazz and still have a slight spot before my period. Advise how to treat? What is most effective? I am 35 years old. I also heard that the problem can be solved with the help of the Mirena IUD.

Reviews

I was diagnosed with uterine adenomyosis; as prescribed by the doctor, I started taking Duphaston, but over the next two months I quickly gained 10 kg, so I quickly ran to the gynecologist to change my medication.

One fine day I noticed that instead of a stable cycle, some strange smudge began after my period, in the second cycle it all repeated, and then I began to notice that between menstrual cycles there were pain sensations, especially during intimate relationships, I consulted a doctor , based on the results of all the examinations, it was discovered that in the second half of the cycle my hormones were not normal: progesterone was low. The doctor diagnosed adenomyosis.

I took Duphaston for 3 months as prescribed, the side effects were a little nausea and swollen breasts, but after three months the cycle stabilized, on an ultrasound the doctor said: “what a beautiful endometrium you have” and removed all diagnoses.

General characteristics of the drug

The active ingredient of Duphaston is dydrogesterone. This is a synthetic analogue of the natural female hormone progesterone. The drug is available in 10 mg tablets. Packed in contour cells of 20 and 28 pieces in a blister.

Duphaston is available in the form of round, biconvex white tablets with a beveled edge, with a breaking line and “155” markings on both sides.

Duphaston is prescribed internally. The drug is quickly absorbed from the digestive tract. The maximum concentration in the blood is observed after 0.5-2.5 hours. Completely excreted in urine after 72 hours.

The cost of one package of Duphaston (28 pieces) is 800-1000 rubles. Depending on the dosage of the drug, this will last for 9, 14 or 28 days. The course of treatment lasts 6-9 months.

Indications for the use of Duphaston

According to the instructions for use, dydrogesterone is prescribed in the following situations:

Endometriosis;
Menstrual irregularities without an organic cause;
Premenstrual syndrome;
Infertility due to luteal insufficiency;
Habitual miscarriage due to lack of progesterone;
Threatened spontaneous miscarriage in early pregnancy.

During menopause, Duphaston can be prescribed against the background of estrogen replacement therapy.

During menopause, Duphaston can be used against the background of hormone replacement therapy.

Indications for use of the drug are determined by a gynecologist. Self-administration of a hormonal drug is unacceptable.

For internal endometriosis (adenomyosis), Duphaston is prescribed in the following situations:

Germination of heterotopias to the submucosal and half of the muscular layer of the uterus (stages I-II of the disease) in the presence of symptoms of adenomyosis (menstrual irregularities, pelvic pain);
Planning pregnancy against the background of adenomyosis;
Preparation for surgical treatment.

In stage III of the disease, Duphaston is not always prescribed. In this situation, the question of surgical treatment is raised. In stage IV, medications are practically not used.

Until recently, it was practiced to prescribe Duphaston for combined lesions of the uterus and the simultaneous detection of several diseases (adenomyosis, fibroids, endometrial hyperplasia). This tactic is now considered controversial. There is an opinion that dydrogesterone provokes the growth of myomatous nodes, so its use is not justified.

Features of the effect of the drug

The main goal of the drug is to stop the effect of estrogens (hypoestrogenism) by quantitatively increasing progesterone (hyperprogestenemia), all of which leads to a minimal increase in the endometrium. Treatment of adenomyosis with duphaston is generally easy to tolerate, improves well-being and reduces pain.

It is known that hormonal drugs do not cure the disease, they only help eliminate painful symptoms and normalize the cycle, so if the drug is discontinued, adenomyosis may return.

The effect of Duphaston during pregnancy is explained by the fact that during the conception of a child, the corpus luteum (temporary endocrine gland) may not produce the hormone progesterone in sufficient quantities; if it is not replenished, a miscarriage or bleeding may occur. Duphaston compensates for the deficiency resulting from impaired functioning of the corpus luteum.

All this is relevant for the first half of pregnancy (up to the twentieth week), then the placenta performs the main job of maintaining the required level of the hormone. In this case, it is necessary to discontinue the drug, but this must be done gradually. The doctor should monitor the dose and gradually reduce it by the twentieth week.

Is Duphaston effective for adenomyosis?

Duphaston is one of the most popular drugs used in the treatment of adenomyosis. Gestagens, along with COCs, are first-line drugs. The following effects are expected with the use of dydrogesterone:

Complete secretory reaction of the endometrium in an estrogen-sensitized uterus;
Suppression of the growth of foci of adenomyosis in the uterus;
Protection of the uterine mucosa from excessive proliferation.

Treatment with Duphaston improves the general condition of a woman:

The duration of menstrual flow decreases;
The volume of monthly blood loss decreases;

When treated with Duphaston, a decrease in the amount of menstrual flow is observed.

Perimenstrual discharge stops;
The risk of developing uterine bleeding is reduced;
The pain in the lower abdomen, lumbar region, and perineum subsides or completely disappears;
Sexual life is normalized (pain goes away during sexual intercourse).

Duphaston significantly reduces the size of foci of adenomyosis, but this is only a temporary effect. There is no convincing evidence that the drug prevents their regrowth. After completion of therapy, relapse of the disease is possible. An increase in heterotopias is observed 6-18 months after discontinuation of the drug.

Duphaston is a proven remedy that allows you to stop the progression of the disease. After a course of taking dydrogesterone for 6-9 months, the menstrual cycle normalizes and the chances of conceiving a child increase. The drug is recommended for women planning pregnancy. It allows you to gain time: to conceive, carry and give birth to a child without complications.

Duphaston does not suppress ovulation and does not prevent pregnancy. But you shouldn’t plan to conceive a child while on therapy. You need to complete the course of treatment to the end and only after that think about pregnancy. During therapy you should use condoms.

Clinical studies show that dydrogesterone, taken continuously or from the first days of the cycle, can suppress ovulation. This effect is not observed every month. But it is for this reason that it is not recommended to drink Duphaston for the treatment of infertility without confirmed ovulation. A good effect is noticed if the drug is not taken strictly from the 16th day of the cycle, but only after the egg has matured. Otherwise, you can suppress ovulation and not wait to conceive a child.

Duphaston for uterine adenomyosis: how to take and reviews of use

A hormonal drug from the group of gestagens - Duphaston - when used regularly, prevents the growth of the endometrium and normalizes menstrual function. The drug does not suppress ovulation, does not have androgenic activity, and does not affect anabolic processes. It is used in the treatment of gynecological diseases in women of different age groups.

Reviews from women who took Duphaston for uterine adenomyosis are mostly positive. The drug reduces the volume and duration of menstrual flow, relieves pain, and improves general condition.

Gestagen inhibits the growth of foci of adenomyosis and prevents the progression of the disease. The drug is well tolerated, and only a small number of women experience unwanted side effects - uterine bleeding.

Reviews from doctors about the use of Duphaston are varied. Gynecologists have still not been able to come to a consensus on when the drug is indicated. Let's take a closer look at the situations in which the prescription of Duphaston is justified and find out how it affects the course of adenomyosis.

General characteristics of the drug

Duphaston is available in the form of round, biconvex white tablets with a beveled edge, with a breaking line and “155” markings on both sides.

The cost of one package of Duphaston (28 pieces) is 800-1000 rubles. Depending on the dosage of the drug, this will last for 9, 14 or 28 days. The course of treatment lasts 6-9 months.

Indications for the use of Duphaston

According to the instructions for use, dydrogesterone is prescribed in the following situations:

Endometriosis,
Menstrual irregularities without an organic cause,
Premenstrual syndrome,
Infertility due to luteal insufficiency,
Habitual miscarriage due to lack of progesterone,
Threatened spontaneous miscarriage in early pregnancy.

During menopause, Duphaston can be prescribed against the background of estrogen replacement therapy.

During menopause, Duphaston can be used against the background of hormone replacement therapy.

It is important to know

Indications for use of the drug are determined by a gynecologist. Self-administration of a hormonal drug is unacceptable.

For internal endometriosis (adenomyosis), Duphaston is prescribed in the following situations:

Germination of heterotopias to the submucosal and half of the muscular layer of the uterus (stages I-II of the disease) in the presence of symptoms of adenomyosis (menstrual irregularities, pelvic pain),
Planning pregnancy against the background of adenomyosis,
Preparation for surgical treatment.

In stage III of the disease, Duphaston is not always prescribed. In this situation, the question of surgical treatment is raised. In stage IV, medications are practically not used.

Is Duphaston effective for adenomyosis?

Duphaston is one of the most popular drugs used in the treatment of adenomyosis. Gestagens, along with COCs, are first-line drugs. The following effects are expected with the use of dydrogesterone:

Complete secretory reaction of the endometrium in the estrogen-sensitized uterus,
Suppression of the growth of foci of adenomyosis in the uterus,
Protection of the uterine mucosa from excessive proliferation.

Treatment with Duphaston improves the general condition of a woman:

The duration of menstrual flow decreases,
The volume of monthly blood loss is reduced,

When treated with Duphaston, a decrease in the amount of menstrual flow is observed.

Perimenstrual discharge stops
The risk of developing uterine bleeding is reduced,
The pain in the lower abdomen, lumbar region, perineum subsides or completely disappears,
Sexual life is normalized (pain goes away during sexual intercourse).

On a note

Clinical studies show that dydrogesterone, taken continuously or from the first days of the cycle, can suppress ovulation. This effect is not observed every month.

But it is for this reason that it is not recommended to drink Duphaston for the treatment of infertility without confirmed ovulation. A good effect is noticed if the drug is not taken strictly from the 16th day of the cycle, but only after the egg has matured.

Otherwise, you can suppress ovulation and not wait to conceive a child.

Scheme of drug use

For the treatment of adenomyosis, two dosage regimens are used:

From the 5th to the 25th day of the menstrual cycle,
In continuous mode from the first day of the cycle.

Duphaston is recommended to be used without interruption from the first day of the menstrual cycle, or from days 5 to 25 of the cycle.

The latter regimen is considered more effective and is more often used in the treatment of adenomyosis.

How to drink Duphaston correctly:

The drug is prescribed 1-3 tablets per day. The dosage is determined by the doctor. It depends on the prevalence of the process, concomitant diseases, individual tolerance and other factors,
You can take the tablets at any time of the day, regardless of meals,
If the doctor has prescribed more than one tablet per day, they must be divided into two or three doses. You cannot take all the pills at the same time.

The course of dydrogesterone therapy is at least 3 months. Usually the drug is prescribed for 6-9 months.

Before starting treatment with Duphaston, a control ultrasound examination is performed. It is recommended to repeat the ultrasound after 3 months, as well as after completing the course of therapy.

Contraindications: who should not take the drug

Duphaston is contraindicated in the following situations:

Vaginal bleeding of unknown origin,
Conditions associated with a high risk of thrombosis and thromboembolism,
Severe liver dysfunction,
Hormone-dependent tumors of any location,
Hypersensitivity to the components of the drug.

Taking Duphaston is allowed during pregnancy, but is not recommended during breastfeeding.

Duphaston is not recommended for nursing mothers.

Negative Side Effects

All side effects of the drug can be divided into groups according to frequency of occurrence:

Frequent: headache, oligomenorrhea and amenorrhea, intermenstrual discharge,
Uncommon: dizziness, nausea, vomiting, depression, skin rash, itching, abdominal pain, jaundice,
Rare: allergic reactions, peripheral edema, hemolytic anemia.

If side effects occur, you should consult a doctor as soon as possible.

Alternative treatment regimens

There are no complete analogues of Duphaston. There are other progesterone-based products on the pharmacological market (Utrozhestan, Visanne, Norkolut). They have a similar effect, but have their own application characteristics. Independent replacement of the drug is unacceptable. If Duphaston is not suitable, you should consult a doctor.

Other medications are also used in the treatment of adenomyosis:

Combined oral contraceptives (Zhanin, Yarina, Belara and others). They contain not only a progestogen component, but also estrogen. Suppress ovulation and provide reliable protection against unwanted pregnancy. There is no reliable evidence that COCs prevent relapse of the disease,
Gonadotropin-releasing hormone agonists (Lukrin-depot, Buserelin). They create an artificial menopause. They act quickly: they suppress the growth of foci of adenomyosis in 3-6 months. There is evidence that AGN-RH prevent relapse of the disease. They have a large number of side effects,
Mirena intrauterine hormonal system. A drug based on gestagen (levonorgestrel). Injected into the uterine cavity for 5 years. Has all the pros and cons of progesterone drugs.

In the treatment of adenomyosis, in some cases, the Mirena intrauterine hormonal system containing a gestagen can be used.

If conservative therapy is ineffective, surgical treatment is indicated. The extent of the operation is determined by the doctor and depends on the extent of the pathological process.

Reviews from women about the treatment of adenomyosis with dydrogesterone

Feedback from women about the use of the drug varies, but positive comments are more common. Many patients are satisfied with the doctor’s prescription.

They note that while taking Duphaston, periods have become less abundant and less painful. Some women experience amenorrhea - absence of menstruation, which is regarded as a beneficial effect for adenomyosis.

Reducing monthly blood loss helps to cope with concomitant anemia and improves general condition.

Negative reviews from women about the use of Duphaston are mainly related to side effects. When using the drug, intermenstrual bleeding is often observed, especially in the first months of therapy. Headaches, including those of the migraine type, are often recorded. Such symptoms force one to refuse treatment.

Duphaston is a hormonal drug, and it inevitably affects a woman’s body.

Compared with other drugs for the treatment of adenomyosis, it is well tolerated, but unwanted side effects cannot be completely excluded.

When used correctly, the drug allows you to get rid of the symptoms of the disease, slow down its progression and avoid the development of complications.

Basic information about the drug Duphaston: active ingredients, route of administration and side effects

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Source: https://afgsm.ru/ginekologiya/primenenie-dyufastona-pri-adenomioze

Scheme of drug use

For the treatment of adenomyosis, two dosage regimens are used:

From the 5th to the 25th day of the menstrual cycle;
In continuous mode from the first day of the cycle.

Duphaston is recommended to be used without interruption from the first day of the menstrual cycle, or from days 5 to 25 of the cycle.

The latter regimen is considered more effective and is more often used in the treatment of adenomyosis.

How to drink Duphaston correctly:

The drug is prescribed 1-3 tablets per day. The dosage is determined by the doctor. It depends on the prevalence of the process, concomitant diseases, individual tolerance and other factors;
You can take the tablets at any time of the day, regardless of meals;
If the doctor has prescribed more than one tablet per day, they must be divided into two or three doses. You cannot take all the pills at the same time.

The course of dydrogesterone therapy is at least 3 months. Usually the drug is prescribed for 6-9 months.

Before starting treatment with Duphaston, a control ultrasound examination is performed. It is recommended to repeat the ultrasound after 3 months, as well as after completing the course of therapy.

Contraindications: who should not take the drug

Duphaston is contraindicated in the following situations:

Vaginal bleeding of unknown origin;
Conditions associated with a high risk of thrombosis and thromboembolism;
Severe liver dysfunction;
Hormone-dependent tumors of any location;
Hypersensitivity to the components of the drug.

Taking Duphaston is allowed during pregnancy, but is not recommended during breastfeeding.

Duphaston is not recommended for nursing mothers.

Symptoms of adenomyosis

Characteristic manifestations:

Dark discharge before and after menstruation;
Moderate and severe PMS;
Heavy menstruation;
Pain in the lower abdomen before, during and after menstruation;
Cycle disruption (mainly contraction);
Discomfort during sexual intercourse;
Changes in the size and shape of the uterus.

It is worth noting that adenomyosis can impair reproductive function. Once in the muscle layer, endometrial cells cannot come out, causing minor hemorrhage, leading to inflammation. Adenomyosis in infertility is diagnosed in every second case.

Alternative treatment regimens

Other medications are also used in the treatment of adenomyosis:

Combined oral contraceptives (Zhanin, Yarina, Belara and others). They contain not only a progestogen component, but also estrogen. Suppress ovulation and provide reliable protection against unwanted pregnancy. There is no reliable evidence that COCs prevent relapse of the disease;
Gonadotropin-releasing hormone agonists (Lukrin-depot, Buserelin). They create an artificial menopause. They act quickly: they suppress the growth of foci of adenomyosis in 3-6 months. There is evidence that AGN-RH prevent relapse of the disease. They have a large number of side effects;
Mirena intrauterine hormonal system. A drug based on gestagen (levonorgestrel). Injected into the uterine cavity for 5 years. Has all the pros and cons of progesterone drugs.

In the treatment of adenomyosis, in some cases, the Mirena intrauterine hormonal system containing a gestagen can be used.

If conservative therapy is ineffective, surgical treatment is indicated. The extent of the operation is determined by the doctor and depends on the extent of the pathological process.

Reviews from women about the treatment of adenomyosis with dydrogesterone

Feedback from women about the use of the drug varies, but positive comments are more common. Many patients are satisfied with the doctor’s prescription. They note that while taking Duphaston, periods have become less abundant and less painful. Some women experience amenorrhea - absence of menstruation, which is regarded as a beneficial effect for adenomyosis. Reducing monthly blood loss helps to cope with concomitant anemia and improves general condition.

Negative reviews from women about the use of Duphaston are mainly related to side effects. When using the drug, intermenstrual bleeding is often observed, especially in the first months of therapy. Headaches, including those of the migraine type, are often recorded. Such symptoms force one to refuse treatment.

Duphaston is a hormonal drug, and it inevitably affects a woman’s body. Compared with other drugs for the treatment of adenomyosis, it is well tolerated, but unwanted side effects cannot be completely excluded. When used correctly, the drug allows you to get rid of the symptoms of the disease, slow down its progression and avoid the development of complications.

Treatment of uterine adenomyosis with duphaston

Recently, gynecologists have seen a problem in the prevalence of endometriosis among women of reproductive age. In 80% of cases, endometriosis affects the uterus - adenomyosis. After adenomyosis is detected at an appointment with a gynecologist, appropriate treatment is prescribed. Duphaston for adenomyosis is one of the leaders in drug therapy for this disease.

This drug is one of the leaders in drug therapy for this disease.

Description of the medicine

Duphaston contains the main substance dydrogesterone - this is a synthetic analogue of the hormone progesterone, it belongs to the group of progestogens.

Progesterone is a very important sex hormone; pregnancy will not occur if it does not prepare the uterus for embryo implantation.

Under the influence of progesterone, the endometrium is transformed in order to accept a fertilized egg; at the onset of menstruation, progesterone levels rapidly drop.

The fact is that the cause of adenomyosis is a violation of the normal rejection of endometrial cells during menstruation; instead, endometrial cells penetrate into the muscular layer of the uterus.

Before ovulation, the endometrium grows under the influence of estrogen, and after ovulation, progesterone suppresses its activity and ensures secretory changes in it. Taking Duphaston promotes increased suppression of estrogen activity - this, in turn, leads to the occurrence of atrophic processes during endometrial growth.

Obvious advantages of Duphaston:

There are no unwanted side effects typical of other hormonal drugs.
Affordability, because treatment of adenomyosis with gonadotropin-releasing hormone agonists is very expensive.
This medicine is widely used if a blood test reveals a lack of progesterone; in its pharmacological properties it is close to the natural hormone, so it can quickly restore the balance.
Blood clotting and other indicators do not change.
The medicine is widely used to increase the level of progesterone, which is not enough to conceive a baby and carry a pregnancy to term.
There is no suppression of ovulation or disruption of menstruation, so it is possible to conceive a baby while taking the drug.
Stabilizes the menstrual cycle and reduces pain associated with adenomyosis and other pathologies.

Women take duphaston in the hope of becoming pregnant.

Rules of application

You cannot use Duphaston on your own! To prescribe the drug, you should contact your gynecologist; it is released strictly according to your prescription. It is customary to take Duphaston from the fifth to twenty-sixth day of the cycle or from the 16th to 25th day for 3-12 months.

It is recommended to take Duphaston at the same time of day.

Dosage

Used as prescribed by a doctor according to an individual course. One tablet of Duphaston contains 10 grams.

Dosage prescribed in the instructions:

For endomitriosis (adenomyosis), 2(3) tablets per day from day 5 of the cycle to day 25, but continuous use is possible.
Infertility caused by luteal insufficiency, 1 tablet per day from 14 to 25 days of the cycle, the course of treatment is more than 6 cycles without breaks between them, in the first months of pregnancy treatment should not be abruptly stopped due to the threat of miscarriage.
For painful menstruation: 1 tablet 2 times a day from 5 to 25 days of the cycle.
For irregular periods, take 1 tablet 2 times a day from the 11th to the 25th day of the cycle.
To prevent heavy discharge in the middle of the cycle (dysfunctional uterine bleeding), take 1 tablet 2 times a day from 11 to 25 days of the cycle, in order to stop bleeding 1 tablet 2 times a day for 5–7 days.

Features of the effect of the drug

Treatment of adenomyosis with duphaston is generally easy to tolerate, improves well-being and reduces pain.

It is known that hormonal drugs do not cure the disease, they only help eliminate painful symptoms and normalize the cycle, so if the drug is discontinued, adenomyosis may return.

The effect of Duphaston during pregnancy is explained by the fact that during the conception of a child, the corpus luteum (temporary endocrine gland) may not produce the hormone progesterone in sufficient quantities; if it is not replenished, a miscarriage or bleeding may occur. Duphaston compensates for the deficiency resulting from impaired functioning of the corpus luteum.

Contraindications and side effects

Contraindications include severe liver dysfunction and intolerance to dydrogesterone.

Side effects of Duphaston:

Hemolytic anemia and hypersensitivity to the drug are extremely rare - skin rash, itching, urticaria (Quincke's edema), peripheral edema.

Attacks of headache and weakness are possible.
Very rarely, minor disturbances in the functioning of the liver may occur; symptoms of this condition are weakness, jaundice in the abdominal area.
In rare cases, bleeding may occur outside of menstruation , which stops with increasing dosage of the drug; increased tension in the mammary glands.
Nausea rarely occurs.
Sometimes weight gain is observed.
Many people talk about the harmful effects of duphaston on the fetus in the womb; there is no clear medical confirmation of this, but there are some reviews from mothers in which they associate kidney problems (entrainment of the pelvis), the appearance of hemangiomas, and cysts with taking this medicine.

An analogue of Duphaston is Utrozhestan; it has the same indications for use, but its distinctive feature is that it contains a natural hormone obtained from plant materials.

Very often it is used in cases where Duphaston is not suitable. Utrozhestan is produced not only in tablets, but there are also special capsules that need to be inserted into the vagina, in this case a local treatment effect is achieved that does not affect the entire body.