Vaginal suppositories Neo-Penotran Forte are successfully used to treat mixed infections of the female reproductive system. As practice shows, this drug successfully eliminates fungal diseases and is effective against pathogenic bacteria. Therefore, it is prescribed in the presence of a mixed form of pathogens, or if the cause of inflammation for some reason could not be established. Despite the effectiveness of the medicine, you can find many reviews that during its use yellow or bloody discharge, mucus with flakes appeared. Therefore, many are concerned about the question: is it dangerous and is it worth continuing treatment.
NEO-PENOTRAN FORTE L (NEO-PENOTRAN FORTE L)
Unless otherwise recommended by your doctor, 1 suppository is inserted deep into the vagina at night for 7 days.
For recurrent disease or vaginitis resistant to other treatment
It is recommended to extend the course of treatment to 14 days.
Suppositories should be inserted in a lying position deep into the vagina using the disposable finger tips provided.
In rare cases
hypersensitivity reactions (skin rashes) and side effects such as abdominal pain, headache, vaginal itching, burning and irritation of the vagina are observed.
The incidence of systemic side effects is very low, since with vaginal use of metronidazole contained in Neo-Penotran Forte-L vaginal suppositories, the concentration of metronidazole in plasma is very low (2-12% compared to oral administration).
Miconazole nitrate
. like all other antifungal agents based on imidazole derivatives that are introduced into the vagina, it can cause vaginal irritation (burning, itching) (2-6%). Such symptoms can be relieved by the local anesthetic effect of lidocaine. In case of severe irritation, treatment should be discontinued.
Side effects associated with systemic use of metronidazole
. include hypersensitivity reactions (rarely), leukopenia, ataxia, psycho-emotional disorders, peripheral neuropathy with overdose and long-term use, convulsions; diarrhea (rare), constipation, dizziness, headache, loss of appetite, nausea, vomiting, abdominal pain or cramps, changes in taste (rare), dry mouth, metallic or unpleasant taste, increased fatigue. These side effects occur in extremely rare cases, since blood levels of metronidazole when used intravaginally are very low.
Contraindications for use
— I trimester of pregnancy;
- severe liver dysfunction;
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
Metronidazole and lidocaine belong to category B, miconazole to category C. After the first trimester of pregnancy, Neo-Penotran Forte-L can be used under medical supervision in cases where the expected benefit outweighs the potential risk to the fetus.
Breastfeeding should be stopped because... Metronidazole passes into breast milk. Feeding can be resumed 24-48 hours after the end of treatment. It is not known whether lidocaine passes into breast milk. A nursing woman should take lidocaine with caution.
Use for liver dysfunction
Contraindicated in severe liver failure.
In cases of severe liver dysfunction, the clearance of metronidazole may be impaired.
Metronidazole may cause symptoms of encephalopathy due to elevated plasma levels and should therefore be used with caution in patients with hepatic encephalopathy.
In patients suffering from hepatic encephalopathy, the daily dose of metronidazole should be reduced to 1/3.
In patients with reduced liver function, the half-life of lidocaine may increase twofold or more.
Use for renal impairment
In case of renal failure, the dose of metronidazole should be reduced.
Other complaints from patient reviews
In addition to atypical discharge, there are unpleasant symptoms that also worry women a lot:
- Itching;
- Burning;
- Rash;
- Metallic taste in the mouth;
- Digestive problems;
- Dizziness;
- Stomach ache;
- Weakness.
Why do patients sometimes feel such unpleasant symptoms when using Neo Penotran? The fact is that antibiotics are not very easily tolerated by the body, but antifungal agents are completely toxic. And if you use them orally, through the digestive tract, there will be even more side effects, and local forms are more easily tolerated by patients.
Is it worth it to endure? Depends on the intensity of the sensations. If a woman is very ill, she cannot live as usual, work, eat, walk, then treatment is stopped immediately.
Patients often complain of burning, itching and pain in the urethra when using Neo Penotran. To reduce symptoms, doctors advise, after installing the suppository, to lift the pelvis up, you can put a pillow or legs on the wall for 10 minutes. Stick the candle deep, then do not get up for half an hour. If any remaining product leaks out, wash thoroughly with warm water.
What can replace Neo Penotran?
Suppositories cause side effects and are very expensive - 800-1000 rubles, so many are trying to find an analogue:
- Klion D;
- Metromicon Neo;
- Gynocaps;
- Miconazole and Metronidazole suppositories together;
- Flagyl;
- Fluomizin;
- Trichopolum;
- Clotrimazole;
- Terzhinan;
- Livarol;
- Ginalgin;
- Vagiferon.
These drugs also have a combined antimicrobial effect, and the first 4 options have almost the same composition. But doctors still advise that if atypical discharge and unpleasant symptoms appear, contact a gynecologist so that he can select another remedy.
How to use Neo-Penotran suppositories. What to replace (analogues)
Have you been trying to cure FUNGUS for many years?
Head of the Institute: “You will be amazed at how easy it is to cure fungus by taking the product for 147 rubles .
Selectivity in sexual intercourse and cleanliness cannot protect women from vaginal diseases.
Their first symptoms create internal discomfort and worsen the quality of life. Vaginal infections require immediate treatment, otherwise various complications may arise.
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Neo Penotran Forte suppositories, a modern medicine with antimicrobial and antibacterial properties, help patients quickly eliminate gynecological problems.
What does Neo-Penotran consist of?
Vaginal suppositories contain an active substance such as metronidazole. It has antimicrobial properties. Miconazole nitrate is also present. Witepsol is used as the basis for the production of the drug.
Depending on the concentration of active components, candles are divided into several types:
- Neo-Penotran containing 500 mg metronidazole and 100 mg miconazole nitrate.
- Neo-Penotran Forte contains 750 mg of metronidazole and 200 mg of miconazole nitrate.
- Neo-Penotran Forte - L - contains the same dosages of active substances as the version labeled “Forte”. But the composition also includes lidocaine - 100 mg.
Metronidazole is a synthetic medicine with trichomonacid, antimicrobial, antiulcer and antibacterial effects. Affects gardnerella, trichomonas, Helicobacter pylori, Escherichia and amoebas. Vaginal suppositories with metronidazole effectively treat vaginitis, urethritis, colpitis, endocervicitis, and nonspecific bacterial vaginosis.
Miconazole nitrate has anti-inflammatory and fungicidal properties. Inhibits candida strains, aspergillosis and malassezia fungi, staphylococci and streptococci without changing the own composition of the vaginal microflora and the acid-base environment.
Witepsol is a compound of unsaturated fatty acids that is compatible with a variety of medicinal substances. Lidocaine gives an analgesic effect, reduces irritation, itching and burning.
Miconazole destroys fungal cells, and metronidazole prevents the proliferation of microbes in the blood. This ability allows the drug to be used in the treatment of thrush, since it acts at the site of accumulation of fungal infection.
Indications for use suppository
The manufacturer recommends using Neo-Penotran Forte suppositories for the following indications:
- Bacterial vaginosis.
- Urogenital candidiasis.
- Vulvovaginitis trichomonas.
- Mixed infections of the reproductive system.
- Anaerobic vaginosis.
- Nonspecific vaginitis.
Often, when a burning sensation occurs and abnormal vaginal discharge appears, women try to self-medicate and buy tablets or suppositories for the fungus, thinking that they are worried about thrush. This cannot be done, since each drug, including Neo-Penotran Forte, has its own contraindications.
Who should not use Neo-Penotran suppositories:
- For virgins.
- Girls under 14 years old.
- People sensitive to the components of the drug.
- Nursing and pregnant women in the 1st trimester.
- Patients with central nervous system diseases, porphyria, liver disorders, epilepsy.
During the period of use of suppositories, it is strictly prohibited to consume alcoholic beverages.
How to treat vaginal infections with Neo-Penotran Forte suppositories
If the doctor did not say anything about the specifics of treatment with Neo Penotran suppositories, the patient will find this information in the instructions for use of the intravaginal drug. The classic regimen involves administering one suppository at night for 1 week. For acute infectious conditions of the genital tract, the course of therapy can last up to 2 weeks.
The suppository is inserted deep into the vagina with a finger dressed in a disposable fingertip. Using the medicine before bed, when the body will be in a supine position all night, allows the active substances to completely dissolve and penetrate into the vaginal mucosa.
How long can and should Neo-Penotran suppositories be used? The instructions say that the therapeutic course lasts 7 days. But in severe cases, when a woman has recurrent inflammation or a resistant infection, the gynecologist has the right to increase the daily dosage of Neo-Penotran Forte to two suppositories and extend the course for another 7 days.
Indications and contraindications
Despite their effectiveness, candles have many contraindications. Do not forget that the active ingredient of the drug is a substance that can destroy not only pathogenic bacteria, but also good microflora. Therefore, after treatment it is necessary to take a course aimed at restoring beneficial bacteria.
Contraindications to the use of the medicine are:
- Allergy.
- Liver problems.
- The first fifteen weeks of bearing a baby, then if there are serious indications.
- Lactation period: the antibiotic penetrates into milk. You can feed the baby two days after the last suppository.
- Frequent seizures.
- Epilepsy.
- Problems with the central or peripheral nervous system.
- Failures associated with blood synthesis.
- Children, virgins.
Important! Neo-Penotran and alcohol are incompatible, so drinking alcohol can provoke a series of negative reactions in the body. Alcohol should not be consumed three days before and after the start and end of treatment.
It should be remembered that during therapy you cannot be sexually active. This will not only make the woman feel uncomfortable during sex, but also expose her partner to the risk of infection.
How to use Neo-Penotran suppositories
Neo-Penotran suppositories contain antibiotic and antifungal agents, so they have antimicrobial, antiprotozoal and fungicidal effects. Metronidazole and miconazole are the main components that are part of the drug "Neo-Penotran Suppositories". An analogue of the specified drug is “Klion-D 100”.
Metronidazole has an antifungal effect and is effective against protozoa. After the interaction of this substance with proteins, the DNA of microorganisms is destroyed, as the synthesis of nucleic acids is inhibited. It is effective in killing most protozoa that cause vaginal infections.
Neo-Penotran suppositories also contain miconazole, which has a fungicidal effect. This component causes a disruption in the synthesis of fungal cell components, which leads to their death. Miconazole is effective against pathogenic fungi, and it also has some bacteriostatic effect against gram-positive microorganisms.
During intravaginal administration, a little metronidazole enters the systemic circulation, after which it is excreted in the urine within 7-12 hours, and miconazole is not detected in the blood.
"Neo-Penotran" suppositories - indications for use
This drug is used for local treatment of trichomonas, as well as bacterial vaginitis, vaginal infections caused by fungi or mixed flora that are sensitive to the components of this drug.
Mode of application
The duration of the course of treatment, as well as the dose of the drug, are selected by a specialist in each case individually. Usually they take one suppository per day, preferably at night, and it is necessary to place it as deep as possible in the vagina. The full course of treatment with this drug is 14 days.
In some cases, to obtain faster results, the doctor may prescribe Neo-Penotran suppositories 2 times a day. But let us remind you that they should be taken only after consultation and examination by an appropriate specialist. This medication regimen lasts seven days 7 days.
When administering the drug, it is best to use a special cap that is placed on your finger. The use of Neo-Penotran suppositories for elderly people does not require dose adjustment.
Side effects when using Neo-Penotran
Some patients may experience local side effects, while systemic side effects develop extremely rarely. Among the common reactions, it should be noted the appearance of burning, itching, hyperemia of the mucous membrane of the perineum and vagina. If you have vaginal infections, irritation may increase on the first and third days of taking the drug. But all these symptoms pass very quickly, but if they are pronounced, then you should stop taking the drug.
Among the systemic side effects, the most common are dizziness, headache, ataxia, and increased irritability. Nausea and vomiting may also occur, stool disturbances may appear, as well as pain in the epigastric region, the activity of liver enzymes may increase, or taste disturbances may occur.
Neo-Penotran suppositories are not recommended for use during pregnancy, especially in the first trimester; in the future, they are prescribed only in cases of extreme necessity, and are taken exclusively under the supervision of a doctor. During lactation, when taking Neo-Penotran, breastfeeding must be stopped and it can be resumed only two days after the last time the drug was taken.
The use of Neo-Penotran is contraindicated for epilepsy, severe liver diseases and for the treatment of children.
