How many days does your stomach hurt after embryo implantation in the uterus?

How much does your stomach hurt during embryo implantation? Embryo implantation

The birth of a new life is not as easy a process as it actually seems and as young couples planning to add to their family would like.
After all, before forming an embryo and continuing its further development, male and female reproductive cells do a tremendous amount of work. If fertilization of a mature egg has occurred, it does not mean that pregnancy has occurred. It is much more important to know that the process of embryo implantation has taken place - the attachment of a fertilized egg to the walls of the uterus. The female body is designed in such a way that approximately in the middle of the menstrual cycle it becomes ready for conception: a mature egg is released from the ovary, retaining its functions for another two days. This condition in gynecological practice is called ovulation. If fertilization by sperm does not occur within these 12 or 24 hours, the female reproductive cell dies and is removed with the next menstruation. When two or three eggs are ovulated, a woman can have several children at once.

At the same time, many other accompanying processes also occur: the consistency of the mucous secretions in the cervix becomes thinner, and the cervical canal expands to allow the passage of male reproductive cells, the woman’s mood changes, her desire increases, and the blood supply to the genital organs increases. The egg continues its development in the fallopian tube, moving to the farthest section to meet sperm, of which about 500 million are released as a result of sexual intercourse.

In order to “get” to the egg, they have to overcome the path from the cervix to the ampullary region (the far section of the fallopian tube), encountering certain obstacles on their way, since the vaginal environment is destructive for sperm. Out of several million eggs, only a couple of three thousand reach the goal, where the most active ones retain their viability for about 5 more days. The female body helps them survive by creating a favorable habitat, because during ovulation a woman’s body temperature rises to 37 degrees. As is known, with these indicators sperm are most mobile.

After fertilization of a mature egg has occurred, the female sex hormone estrogen is activated, which prepares the uterine mucosa for the process of implantation of a fertilized egg into the uterus.

Can there be nagging pain in the lower abdomen during implantation?

Anticipation of pregnancy is always accompanied by anxiety; the expectant mother wants to know about a successful conception even before her menstruation is missed.

In fact, the process of egg maturation, its release and successful fertilization is not asymptomatic.

Women who are sensitive to the processes occurring inside can easily determine the moment of ovulation, but they can also feel the process of fixation of the fertilized cell; for this, you need to know what sensations accompany the implantation of the embryo into the uterine tissue.

How does the implantation process occur?

After the egg is fertilized by the most active sperm, it becomes covered with a membrane and begins to actively divide; this process occurs while moving through the fallopian tubes.

Scheme of attachment of a fertilized egg to the uterus

Having reached the uterus, the cell sheds its protection to attach to the epithelium. Implantation of the embryo into the uterine tissue is a stage whose successful completion leads to pregnancy.

Timing of implantation

The egg reaches the uterus approximately 7-9 days after fertilization.

The duration of the trip is influenced by factors such as:

Hormonal background of the mother's body.
Embryo viability.
Pathologies in the structure of the fallopian tubes.

According to medical research, the implantation of the embryo occurs 7-12 days after the release of a mature egg, and the probability of implantation immediately before the onset of menstrual bleeding is quite high.

Process of egg division

The implantation process lasts from several hours to 3-4 days, the average is 40 hours after reaching the uterus.

Throughout this time, with variable activity, the egg attaches to the epithelium and tries to get along with the mother’s body.

It is this fact that explains the episodic nature of the sensations accompanying the final stage.

The life span of an embryo is no more than 14 days; after this period, the embryo dies and is excreted with menstrual bleeding.

Embryo implantation: sensations, signs, discharge

The attachment of a fertilized cell is always accompanied by changes in the woman’s body, the most obvious of which are:

Pain in the mammary glands during embryo implantation

Increased body temperature

Temperature monitoring must be done daily, after a long sleep, without getting out of bed.

The most reliable indicator of conception is basal body temperature, measured in the mouth, vagina or rectum.

Throughout the entire cycle, the temperature varies from 36.2-36.5 0 C (during cell maturation) to 37 - 37.5 0 C (with successful conception).

This increase is due to the production of progesterone, which ensures the safety of the resulting pregnancy.

Increased body temperature

Thus, it is quite simple to track the implantation stage on the basal chart; it is accompanied by a significant increase in temperature.

Increased pregnancy hormone

It is possible to identify the stage of attachment in laboratory conditions by monitoring the level of hCG in a woman’s blood.

This hormone is produced by the placenta, and its growth indicates the successful completion of implantation.

Changes in the cervix

The hormonal background of the female body directly affects the condition of the cervix.

Embryo implantation is accompanied by the following changes:

Colors. A healthy neck, under normal conditions, has a slightly pinkish tint. Completion of the stage is accompanied by increased blood circulation in the pelvic organs and the appearance of new vessels, which is accompanied by a change in color to bluish.
Densities. The onset of pregnancy makes the cervix more flexible and soft.
Placements. Due to the enlargement of the uterus, the cervix is located slightly lower than it was before.
Slime. During ovulation, vaginal secretion becomes more fluid, which allows sperm to move actively; after fertilization of the cell, under the influence of produced hormones, the mucus becomes thicker and more viscous.

Signs that a woman can feel are:

Pain in the mammary glands

Painful sensations are caused by hormones produced that promote the growth of the mammary glands.

Nagging pain in the lower abdomen

The most common sign confirming the attachment of the embryo to the uterus is sensations caused by damage to the mucosa.

Pain in the lower abdomen during implantation of the embryo

Such changes may not only indicate successful conception, but also problems that require medical intervention:

inflammation of the uterine cavity, accompanied by sharp, cutting pain;
spasm of the smooth muscles of the uterus, caused by metabolic disorders and accompanied by attacks of severe pain;
ectopic pregnancy - a fertilized cell attaches to tissue outside the uterus.

Nausea and vomiting

Nausea, digestive system disorder - the cause of such ailments can be egg implantation, the sensations are caused by an increase in progesterone levels.

Vomiting as one of the symptoms of fertilization

It is worth noting that these symptoms are not a harbinger of pregnancy in the following cases:

Frequent vomiting.
Profuse diarrhea.
Feelings of bloating.
Temperature rise above 38 0 C.
Severe headache.

The appearance of bloody discharge

Damage to the epithelium during cell attachment contributes to the appearance of reddish or brownish discharge.

As a rule, the secretion released is not abundant and usually disappears within 1-2 days.

Longer, scanty bleeding may indicate a pathology in the development of the embryo or its improper implantation.

Conclusion

What sensations occur when the embryo attaches to the uterus?

Often, implantation is accompanied by increased weakness and drowsiness, which is caused by changes in hormonal levels in the female body.

Mild pain during embryo implantation is normal and lasts no more than 2-3 days.

It should be remembered. that the listed symptoms may be a sign of diseases not related to pregnancy, therefore, if pain occurs, you should consult your doctor.

Feelings and signs during embryo implantation

Implantation is the process of implantation of a fertilized egg into the endometrium of the uterus. If this process goes wrong or does not take place at all, pregnancy will not occur. Therefore, women who have been expecting and planning a pregnancy for a long time try to catch the subtlest nuances of sensations in order to understand whether it happened or not.

Timing and process

Conception has occurred. But this is not enough.

It is necessary that the fertilized egg successfully travels from the fallopian tube, where it meets the sperm, to the uterine cavity, where the baby will grow and develop throughout pregnancy. The zygote, into which the oocyte has turned after fertilization, begins this journey on the first day after conception, and it usually takes from 3 to 5 days.

Then for another 1-2 days, and sometimes longer, the fertilized egg floats freely in the uterine cavity. It feeds on the beneficial substances contained in the uterine fluid and waits patiently until it is “nailed” to the wall of the uterus.

If this does not happen, after 4-5 days the fertilized egg will die and come out along with the next menstruation, the woman may not even realize that she was “almost pregnant.”

The zygote passes the morula stage and becomes a blastocyst. It has two shells. The internal one will then become the basis for the formation of the child’s internal organs, and the external one is responsible for the process of implantation, and then for the process of formation of the placenta.

The blastocyst adheres to the wall of the uterus. From this moment implantation begins. The average time is 7-8 days after ovulation . But there is later or earlier implantation. The process of implantation of the blastocyst into the uterine wall lasts about 40 hours.

Having adhered to the endometrium, the outer layer of the blastocyst is transformed into thin villi-conductors. At first, they produce enzyme substances that dissolve endometrial cells. The fertilized egg is buried in the resulting space as deeply as possible. Then the villi connect with blood vessels and form the chorion.

Once implantation is complete, the embryo begins to receive nutrients from the mother's blood.

Pregnancy has occurred, but the woman finds out about this only when a sufficient amount of a special hormone produced by chorion cells, hCG, has accumulated in the blood and urine.

This will happen just before or just after your missed period, which is about a week after implantation.

Feelings and signs

Officially, in medicine it is believed that a woman does not experience any special signs or sensations during implantation. The process is so microscopic, cellular, that it is almost impossible to feel anything. However, reviews from women clearly show that many managed to feel implantation, and for a number of expectant mothers it was quite painful.

Not everyone feels implantation. This depends on individual sensitivity, primarily to changes in hormonal levels.

Most often, women describe their feelings like this:

The lower back hurts a little, like before menstruation (but it’s about a week before menstruation, and therefore few people pay attention to these sipping, weak, barely noticeable pains);
the lower abdomen may hurt, but there is no severe pain, only minor aching discomfort that lasts about two days and passes;

the temperature rises slightly (no higher than a little over 37.0, and therefore the woman may not pay attention to this either);
a headache, a sore throat, a cough and chills may appear - immunity decreases sharply during implantation to give the fertilized egg a chance not to be rejected by vigilant immune cells, and usually women perceive these sensations as a signal that they simply have a cold or have caught a virus;
drowsiness increases, the woman feels overwhelmed, tired, and a slight anxious feeling may appear;
many say that they felt a faint metallic taste in their mouth - medicine does not know how to explain this.

The only more or less reliable signs include so-called implantation bleeding.

During the process of implantation of the fertilized egg into the endometrial layer, enzymes dissolve the cells of the inner lining of the uterus, and the released blood can come out. There is not much blood, because it is not the veins or arteries that are damaged, but the smallest blood vessels of the human body - the capillaries.

Usually women react with bewilderment - there is still a week or even more before menstruation, and they attribute the appearance of bloody spotting to a malfunction in the cycle. However, implantation discharge has nothing to do with menstruation, and after just a day there is no trace of it .

This sign does not appear in all women, and therefore you should not rely on it as an early diagnosis of pregnancy. This is one of the medical mysteries, the mechanisms of which scientists have still not been able to explain.

One thing is certain - such bleeding in no way affects the development of the fetus, the condition of the mother, the pregnancy itself, and does not affect the course of childbirth.

If a woman regularly measures her basal temperature, then at 40 hours of implantation she can pay attention to the rise in the thermometer to 37.4-37.5 degrees .

If the temperature is higher and there is pain, then we are talking about an inflammatory process, and not about embryo implantation.

The hCG level rises every two days, doubling its values. Therefore, theoretically, and again not for everyone, after 4-6 days a woman may experience the first changes in her body and well-being caused by a change in the balance of hormones.

Such signs may include mild nausea, dizziness, attacks of weakness, increased fatigue, and a rise in temperature in the evening to subfebrile levels.

Many women describe that during this period their mood began to change dramatically - from sadness to joy, from frustration to anger.

Women also note that they became more sentimental and somehow especially related to touching photos of babies, kittens, puppies and other “cutes” if they met them on the Internet.

Source: https://sfmggu.ru/mogut-li-byt-tyanuschie-boli-vnizu-zhivota-pri-implantatsii/

Embryo implantation: the essence of the process

It is amazing how many changes a woman’s body undergoes in order to conceive a child. And only after the embryo is implanted into the uterus can we talk about pregnancy.

After leaving the ovary, the fertilized egg reaches the uterus after 7 days, during which time it goes through 3 stages of development:

A zygote is a fertilized egg divided in two.
Then the morula, which has up to 32 cells, which undergo division every 15 hours. After 90 hours she has up to 64 cells. Of these, several form the fetus, and the rest will be involved in the formation of the membrane and placenta.
A fluid-filled blastocyst ball contains cells that will directly become an embryo.

After reaching the uterine epithelium, the blastocyst loses its protective shell and attaches to the wall of the uterus. If the membrane is too thick, implantation may not occur. Thanks to natural selection, only a healthy blastocyst manages to gain a foothold in the uterine lining. Otherwise, a pathologically “unhealthy” embryo may be rejected by the female body, and the pregnancy will be terminated.

The main reasons for failed implantation are:

genetically abnormally developed blastocyst;
the membrane of the fertilized egg is too thick;
thickened uterine epithelium (normally this parameter should be 10-13 mm);
lack of nutritional components in the uterine tissue.

Feelings when an embryo is implanted in the uterus

Anticipation of pregnancy is always accompanied by anxiety; the expectant mother wants to know about a successful conception even before her menstruation is missed.

In fact, the process of egg maturation, its release and successful fertilization is not asymptomatic.

Embryo implantation: on what day does consolidation occur?

As a rule, the introduction of a blastocyst into the uterine epithelium can occur from 3 hours to several days. During this period, the fertilized egg is looking for a convenient place where it is tightly attached due to troboblast. This process sometimes pauses for a while and then continues again. If the embryo has managed to establish itself well, then there is a high probability that it will overcome all sorts of difficulties in the future.

The woman’s body, in turn, at this stage is not yet ready to perceive the cells of the unborn child, reacting to them as a foreign body. In the early stages of pregnancy, he will try to get rid of this invasion, so during the implantation period it is extremely important for the expectant mother to behave very carefully and prudently.

In obstetric practice, there are two conventional categories of the implantation process:

late embryo implantation - occurs after the egg has been fertilized, approximately on the 10th day. It is especially favorable if artificial insemination is carried out. In cases where it would seem that pregnancy should not happen and is no longer expected, late implantation becomes a surprise;
early implantation of the embryo occurs less frequently and occurs mainly on the 7th day after ovulation. It is generally accepted that during this period the uterus is not yet ready for implantation, but implantation is not excluded and pregnancy is still possible.

In order for the embryo to implant well and smoothly in the uterine epithelium, it is also necessary that certain conditions in the female body correspond to this:

thickness of the uterine mucosa – no more than 13 mm;
In order for the embryo to continue its vital activity in the walls of the uterus, the presence of certain nutrients is necessary;
A woman's progesterone levels must be normal to promote embryo development and delay of menstruation.

Useful tips for expectant mothers

From the first days of conception, a woman must radically change her lifestyle and treat herself with care. Now you are responsible not only for yourself, but also for the little baby in your tummy. Start with the simplest:

Categorically give up bad habits. If no one can stop you from slowly poisoning your body, then now you should know that alcohol and smoking negatively affect the development of the fetus.
If there is a need to take medications, then from the moment of conception all of them must be approved by a doctor.
Try to maintain your immunity at the proper level as much as possible, because now symptoms such as fever and cough are absolutely unnecessary. Drink more fresh vegetable and fruit juices, enrich your diet with folic acid and other microelements beneficial for the baby's development.
Avoid unnecessary moral stress and shock in every possible way. Remember that your good emotions, just like bad ones, are always felt by the child.

Symptoms and signs of embryo implantation

After the embryo has strengthened, the level of the hormone human chorionic gonadotropin (hCG) in the woman’s urine and blood begins to increase. In parallel with this, during implantation of the embryo, the first signs of pregnancy appear. Among them:

Implantation bleeding is the first sign of embryo implantation in the uterus. This is a scanty discharge of blood from the vagina, the amount of which sometimes does not exceed a few drops. Occurs as a result of damage to small vessels on the wall of the uterus after the implantation of a fertilized egg. Discharge during embryo implantation should normally be beige-pink or brown. This symptom can be deceptive if a woman has current infectious diseases of the genital organs.
The process of embryo implantation, as a rule, is always characterized by such a symptom as pain. This can be a nagging pain in the lower back or lower abdomen, sometimes even tingling. Typically, pain is localized at the site of attachment of the embryo.
Changes in basal and general body temperature. A characteristic reaction of a woman’s body to pregnancy is an increase in temperature (up to 37 – 37.3 degrees).
Metallic taste in mouth. This symptom often appears, so women should know that a metallic taste on the tongue is nothing more than a normal course of the process of fixation of a fertilized egg.
During embryo implantation, one of the woman’s feelings may be general malaise, which is accompanied by headache, apathy and dizziness.
Sharp changes in mood and psycho-emotional instability.

Implantation pain - how it manifests itself and how to make sure it’s them

If you're trying to get pregnant, the time between ovulation and when you can use a home pregnancy test can seem like an eternity.

The problem is that two-week waiting period, you're only (potentially) about four weeks pregnant, so the test might not even show an accurate result yet. Many women look for possible implantation symptoms to understand whether conception has occurred.

Cramping and pain can be one of the symptoms of embryo implantation, but sometimes it can be a problem.

When does implantation occur?

Not all women experience pain and cramping, but those who do will notice it when the embryo implants in their womb. Cramping will occur at the same time as implantation, between 6 and 12 days after ovulation. At this stage, your fetus is attached to the uterine cavity.

Some people say that implantation pain is a natural way of hinting to the expectant mother that conception has occurred. This method was used long before scientific pregnancy tests. Because of this, they (pains) can be a cause for anticipation, happiness or nervousness.

How does it feel?

You may feel a slight stabbing or nagging pain that appears in the lower abdomen about a week before the start of menstruation.

Cramps are due to the fact that part of the uterine lining “melts” at the implantation site, which allows the fertilized egg to better attach to its wall.

For some women they sometimes last for several days, while for others they go away very quickly.

How to relieve pain from cramps

Remember that they will not last long, since the embryo implantation process takes no more than 1-3 days. You should not take painkillers in this case. Instead, it is better to lie down and elevate your legs to let the pain go away. You should also drink plenty of fluids and rest. Meditation or yoga may also help in some cases.

If you experience severe cramping during pregnancy, it lasts more than a few days, or occurs after you have received a positive result on a home pregnancy test, you should see your doctor.

Most of the time the pain will be minor due to natural processes such as uterine growth or gas, but there are other possible serious causes including urinary tract infections, preeclampsia, placental abruption, premature labor and miscarriage.

Experiences of other women

Taken from a foreign forum:

“I'm trying to get pregnant for the first time, so I have no experience with this. The nurse told me that some of my symptoms may indicate implantation, but I'm not sure. I'm currently 2 days late, so when I started having some mild cramping in my lower abdomen a few days ago, I thought it was due to my period.

But then they never came, and I had two more cases of acute pain in the same place. They lasted only a few seconds, but today there is a constant (mildly painful) pressure in the lower middle of my abdomen. I took a pregnancy test the next day and visited the doctor a few days later. It turned out that I was pregnant."

Other symptoms of implantation

An additional symptom of embryo implantation is spotting or bleeding, and this occurs in approximately 30% of cases. This occurs when an egg penetrates the wall of the uterus, the color of the discharge is usually light brown, red or pink in very small quantities.

In most cases, discharge appears 6-12 days after ovulation and fertilization. This is approximately one to two days after the blastocyst (embryo stage) enters the uterus.

You should not confuse implantation bleeding with menstruation, as it will occur earlier and be more scanty.

Additional symptoms of early pregnancy may include fatigue, breast changes, frequent urination, nausea and mood swings. You may also experience a drop in temperature 7-10 days after ovulation. However, keep in mind that most of these signs appear later, after six to eight weeks of pregnancy.

When can pregnancy be confirmed?

Even if you experience bleeding during implantation, you cannot be sure that pregnancy has occurred. The exact time you should take a pregnancy test depends greatly on the type of pregnancy test. They all work by measuring the amount of hCG (human chorionic gonadotropin), but home tests detect it in the urine, while a lab test detects it in the blood.

Pregnancy test

It is recommended that you do this test at home a week after your missed period.

You will note that tests can vary greatly in sensitivity, ranging from 10 mIU/mL to 40 mIU/mL. If it is less significant, you can use it earlier, and the most sensitive ones can show results four days before the start of their period.

If you test too early, your urine may not have a high enough concentration of hCG, giving you a false negative result and leading to stress. Other reasons why the result may be negative are if you are not pregnant or simply ovulated later than you thought.

In fact, 10% of women may have extremely low hCG levels when their periods are missed. In this case, if it still does not start after three days, repeat the test, as this will give more time for the hormone levels to rise.

Blood analysis

Your doctor may order you to have a blood test for hCG. It is more sensitive and can detect the hormone 6-8 days after ovulation. Despite this, most doctors do not suggest taking it until late unless you need it for medical reasons.

Early pregnancy symptoms such as implantation cramps, coupled with a test or blood test, will definitely show whether you are pregnant or not.

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Source: https://budumama.club/simptomy-beremennosti/implantacionnye-boli

IVF and embryo implantation

Infertility today is a common diagnosis for many women, for whom the in vitro fertilization method becomes a real salvation, a chance to give birth to a child on their own and become a mother.

Assisted reproductive technology IVF is the process of extracting a mature egg from a woman’s body and fertilizing it in the laboratory. The embryo obtained after the procedure is stored in a special incubator for 2 to 5 days, after which it is transferred to the uterine epithelium.

Embryo implantation during IVF is clearly controlled by an ultrasound machine in a hospital setting. This procedure is painless and takes only a few minutes. During this procedure, a special plastic catheter with an embryo is inserted into the uterine cavity. When the fertility doctor sees on the screen that the device is in the optimal position, he releases the embryo from it along with a drop of nutrient. After implantation of the embryo, the woman remains in the hospital for about an hour.

Pre-implantation studies

Before transplanting an embryo, a reproductive specialist must assess its condition. The healthiest and highest quality ones that can adapt and survive well are subject to replanting. Such preimplantation diagnostics makes it possible to identify possible hereditary syndromes, as well as determine the gender of the fetus.

The successful outcome of embryo implantation after transplantation is also influenced by the condition of the uterus, so before the procedure, doctors must study the size of the endometrium, its structure, the length of the organ, and the condition of the internal os. An ultrasound machine is used. When transferring a fertilized egg, you should avoid touching the fundus of the uterus with instruments, as this can lead to an increase in tone and subsequently to a miscarriage.

The optimal number of embryos to be transferred directly depends on the woman’s gynecological history (presence of abortions or pregnancies in the past). The age and quality of planting material also influences. For women under 35 years of age, up to 2 embryos are transferred during the first IVF cycle. Women after 40 will need a larger amount, since at this age the likelihood of implantation is much reduced.

The successful outcome of the operation is also influenced by the diagnosis of the woman or man, the professionalism of the doctors and the quality of the in vitro fertilization procedure performed.

Embryo implantation during IVF has its own characteristics. An embryo implanted in a woman’s uterus was conceived outside the woman’s body, and therefore requires additional time to adapt. Because of this, the procedure ends successfully only in a third of all cases. Additionally, to reduce the risk of embryo failure, a woman should take care of her body:

sleep well and relax in the fresh air more often;
do not lift heavy objects;
you should stop taking hot baths for a while;
stop having sex temporarily;
it is not recommended to overcool and, conversely, overheat the body;
you need to eat well and not go on strict diets;
try to monitor your immunity and avoid staying in crowded places where viral infections may occur.

A woman needs to be in this state of caring for herself and her unborn baby at least until the 20th week of pregnancy: during this time the placenta will form and the fetus will be additionally protected. According to obstetricians, the implantation process continues all this time, and only then the baby begins to actively grow and develop.

Time for embryo attachment

For pregnancy to occur, the fertilized egg must develop into a zygote and implant in the uterus. After this, it can be considered an embryo. In order for an embryo to take root in the uterus, its walls must be ready to receive it.

According to doctors, conception can be early or late. With early implantation, which occurs no later than seven days after ovulation, the female body is not yet prepared to receive the embryo; the endometrium does not have the required thickness. But such cases happen infrequently. Late attachment usually occurs on the tenth day after fertilization. This period is considered the most favorable when carrying out the IVF procedure.

In a natural pregnancy, the implantation of the fertilized egg takes at least 48 hours, and they are decisive.

If, at this time, the woman’s body perceives the embryo as a foreign body, the embryo may not attach to the uterus, rejection will occur and menstruation will occur. A woman is considered pregnant after the implantation and consolidation of the fertilized egg in the uterus. This takes from one to three days.

In the protocol, the future embryo develops outside the female body, it is implanted when it is already mature, and it is able to take root faster than in a natural pregnancy. This is the difference between IVF and natural conception. Embryos aged 3–5 days have the highest survival rate.

Factors that interfere with implantation

With artificial insemination, pregnancy does not occur in all cases. In order to determine why there is no implantation, doctors find out all the reasons for the embryo not attaching to the uterus during IVF. Sometimes, the egg does not attach to the uterus and conception does not occur.

The reasons for unsuccessful embryo implantation are:

the presence of endometriosis, fibroids;
too thick or thin layer of the endometrium, the thickness of which is ideally from 10 to 13 millimeters;
a large number of abortions;
genetic abnormalities in the embryo that do not allow it to attach;
low levels of the hormone progesterone, which is responsible for creating conditions for fetal development.

Compliance with the last point is of no small importance.

For 12-14 days after the transfer, the woman is advised to follow a gentle regimen, avoid physical activity, and avoid stressful situations.

Lack of implantation during IVF:

low-quality biomaterial;
pathological changes in the endometrium;
hydrosalpinx tubes;
unqualified support during the protocol;
ignoring doctor's orders.

What happens if the embryo does not attach to the uterus?

If the fertilized egg does not attach, the so-called spontaneous termination of pregnancy occurs at a very short time. Sometimes, a miscarriage occurs after implantation, when the body begins to produce the pregnancy hormone and the test shows a positive result.

A high-quality embryo does not take root - what could be the reasons?

The main reasons that the embryo has not attached to the uterus are:

low-quality blastocyst;
endometrium is more than 13 mm;
diseases and pathologies of the endometrium;
hydrosalpinx;
poor quality support;
failure to comply with doctor's orders.

All factors leading to poor-quality attachment can be divided into several groups:

violation of endometrial decidualization;
the effect of controlled stimulation of ovulation;
displacement of the implantation window;
accompanying illnesses;
morphological changes in the structure of the uterine mucosa.

Biochemical pregnancy during IVF: causes, symptoms, hCG level

Attachment of the embryo

The beginning of the natural implantation period is considered to be the time when an embryo with at least 16 cells enters the wall of the uterus and the egg enters the mucous membrane.

The attachment of the fertilized egg in the protocol differs from natural conception in that it is more quickly implanted.

How the embryo attaches to the uterus during IVF:

in the first two days, a zygote is formed from the oocyte, from which an embryo has four cells by the end of the second day;
on the third day there are already eight cells, the embryo is ready for transfer, but the likelihood of pregnancy due to its immaturity is low, and further cultivation occurs to the blastocyst stage, which occurs on the fifth day. This period is considered the best for transfer;
after replantation, within 48 - 72 hours, under favorable conditions, the fertilized egg attaches to the walls and begins to grow, as in a natural pregnancy. But, in order for this to happen, the embryo itself must have the ability to further develop.

It is possible to enter the uterus at the age of 2-4 days, but this is impractical, and the chances of a successful pregnancy are low. After implantation, you need to wait at least two weeks to confirm a positive result.

The fertilized egg is attached in different places. If the embryo is attached high in the uterus, it means that it has implanted close to its bottom, which is the most favorable for its further development. If the embryo does not attach, another menstruation occurs, and the fertilized egg is released along with the discharge.

Definition of pregnancy

14 days after the transfer, if menstrual bleeding has not occurred, you can hope that the IVF was positive and check the result. For this purpose, an hCG (human chorionic gonadotropin) test is prescribed. If pregnancy has occurred, then the indicator will be greater than 0 and correspond to the table value for a certain day. This test will be more accurate than a regular home pregnancy test.

Almost every eco-girl starts taking a pregnancy test a few days after the transplant, rejoicing even at the specter of stripes. If the test after transfer of the embryo to the uterus is negative, an hCG test and ultrasound still need to be done.

If it so happens that IVF did not bring the desired results and the embryo did not attach to the uterus, you should not lose hope of becoming parents. It may take more than one attempt to achieve the goal, but do not forget that according to statistics, the IVF method is considered the most effective.

Why the embryo does not attach to the uterus during IVF Link to main publication

Under favorable conditions, seven days after fertilization of the egg, pregnancy occurs. But, in some cases, this may not happen, due to the fact that implantation of the embryo did not occur. Expectant mothers are interested in why the embryo does not attach to the uterus and what are the reasons.

It takes approximately 2-3 days for the embryo to go through the implantation stage. After this, obvious signs of pregnancy begin to appear. This is a metallic taste in the mouth, as well as mild nausea. You may experience dizziness, increased irritability, and weakness. Some people note an extraordinary emotional uplift and a feeling of endless euphoria, others, on the contrary, depression and resentment towards others.

Helps in the attachment of the embryo

Many patients who have entered into the protocol are interested in the question of why the embryo does not attach to the uterus during IVF. This is influenced by many factors, to eliminate which additional treatment is carried out, increasing the chances of a successful transfer.

The reason that the fetus has not implanted may be poor quality of the endometrium with increased or decreased immune activity. In order to help the embryo implant in the uterus during IVF, additional procedures are prescribed that have a positive effect on the condition of the endometrium and help further implantation.

For example, with a deficiency of immune activity, injection of seminal fluid into the uterus, local irritation of the mucous membrane helps, and if it is too high, intravenous administration of immunoglobulin, follicular fluid into the uterus and other methods.

What to do if the embryo does not attach to the uterus?

There are several factors that influence the fact that the embryo cannot attach. These are pathologies of the female reproductive system, gynecological diseases and genetic abnormalities in the fertilized egg itself. In this case, a detailed ultrasound examination and tests are prescribed to identify the causes. If attempts to get pregnant naturally are constantly unsuccessful, it is recommended to use the IVF procedure. But it is important to remember that it does not provide a complete guarantee.

When will the embryo come out if it has not attached to the uterus?

If the embryo does not take root, it means that the fertilized egg has stopped in its development and will be released from the body during the next menstruation. If the desired pregnancy does not occur, there is no need to despair. You should contact highly qualified specialists who will help you find out all the reasons that are preventing embryo implantation and prescribe the necessary treatment.

Today, families who naturally cannot, resort to. This procedure is expensive and complicated, but if it is successful, the married couple will become happy parents in 9 months.

In vitro fertilization consists of several stages, the most important of which is the implantation of the embryo into the woman’s body. This procedure is not considered difficult, but in order for pregnancy to occur, everything must be done strictly according to the rules of both the doctors and the woman.

Examination before embryo implantation

Before a fertilized egg is implanted into the body, a woman must undergo examinations. Thus, the condition of the uterus, its length and wall thickness are studied. If muscle tone is observed, the woman is prescribed relaxing medications before IVF.

Before implantation, it is necessary to determine the condition of the uterine walls. They must contain the nutrients required for fetal development. If some substances are missing, pregnancy may not occur.

Before embryo implantation takes place, a woman must undergo hormone tests. In her body there must be sufficient quantities necessary for normal gestation.

Before implantation, the embryo is also examined. Of all the fertilized cells, reproductologists select only healthy ones. After all, already at this stage it is possible to diagnose genetic diseases in the embryo.

But even if the procedure was carried out without violations, embryo implantation may not occur. This happens for various reasons. The embryo may have some genetic disease that was not diagnosed before the egg transfer. Often these diseases prevent pregnancy from developing.

The cause may be a painful condition of the uterus, due to which the embryo cannot attach to it. It could also be an infectious disease or mechanical damage caused by the instrument during cell transfer.

Timing of embryo implantation

When a fertilized egg enters the female body, it must move through the fallopian tube. It is considered normal to implant the embryo on the seventh day after artificial fertilization of the egg. If the procedure is successful, the embryo should attach to the wall of the uterus within 40 hours. After attachment, it begins to develop in the same way as an embryo that appears naturally.

Doctors never rule out late embryo implantation, which occurs 10 days after the fertilized egg is implanted. Therefore, married couples are advised to believe in the success of the procedure until the last moment, because pregnancy can occur even when it is not expected.

After embryo implantation, the amount of human chorionic gonadotropin increases in the blood. It is from the moment the level of this hormone increases that the embryo can be visualized on ultrasound. Therefore, late implantation of the embryo cannot be ruled out and hCG should be done periodically - this will allow time to determine the onset of pregnancy and begin to monitor the development of the baby in the early stages.

Signs of successful embryo implantation

After successful implantation of the embryo, the woman begins to experience certain sensations that she did not have before. At first, her breasts begin to hurt slightly and become enlarged. Pain is felt in the lower abdomen. A sign of implantation of the embryo into the uterus is not acute, but dull and nagging pain.

An important symptom of embryo implantation is the appearance of pink or dark brown discharge. They often indicate pregnancy.

Feelings during embryo implantation may be similar to those of food poisoning. There is a constant metallic taste in your mouth, and when you see food you feel nauseous and start vomiting.

Signs of embryo implantation into the uterus are:

irritability,
dizziness,
weakness,
headache,
prostration,
excessive emotionality,
mood swings,
depression

Don't confuse pregnancy with a cold. After all, with successful implantation, you may experience chills for several days and an increase in temperature to 37 and 3. If you are expecting pregnancy and the temperature begins to rise, you should not take antipyretic and antiviral drugs - this can harm the embryo and terminate the pregnancy.

After IVF, a woman needs to listen especially carefully to her body. If you do experience any of these symptoms, it is necessary to find out for sure whether you are pregnant or not.

Regardless of whether embryo implantation occurred naturally or artificially, it has the same type of symptoms: pain in the very lower abdomen, nausea, bleeding, dizziness. In any case, if you have such symptoms, do not delay going to the doctor, because early examination can prevent miscarriage and the development of pregnancy pathologies.

Symptoms of attachment

In order for the embryo to attach to the wall of the uterus, important conditions must be met.
First of all, the endometrial layer in the uterus must have a certain thickness. Implantation is supported by a hormone from the corpus luteum called progesterone. Its main task is to stimulate endometrial growth. In some cases, the shiny protective coating may be too thick. This may create barriers to successful implementation. Immediately after ejaculation, sperm reach an egg that has passed the ovulation period and begin to attack it. After the most active sperm is introduced into it, fertilization occurs, but another 24 hours must pass for the fertilized egg to divide into 2 parts, turning into a zygote.

Subsequently, the division of the egg occurs without interruption until the zygote has 32 paired chromosomes in its genetic set, that is, until the blastocyst is formed. On average, the duration of zygote division and its movement through the fallopian tubes into the uterine cavity is 7 days.

If you count directly from the day of sexual intercourse, then the attachment of the embryo occurs after fertilization of the egg on day 9-10. But there are certain conditions for the fixation of the egg in the uterus to be effective:

the thickness of the outer layer of the endometrium must be sufficient for the further development of the embryo (no more than 13 mm) and contain the necessary amount of nutrients;
in a woman’s body, the concentration of progesterone should exceed normal levels, since it is it that prevents the onset of menstruation, thereby making the development of pregnancy possible.

If these conditions are not met, the egg does not attach to the lining of the uterus and monthly menstrual bleeding begins in the female body, that is, the embryo is rejected, and the processes of maturation of a new egg begin in the ovaries.

Also, a woman planning a pregnancy is interested in whether she will be able to feel the attachment of the embryo in the uterus, because it is from this moment that the development of her unborn baby begins. There are certain symptoms that indicate dramatic changes in the female body, and these are:

During early pregnancy, small discharge from the genital tract may sometimes appear, having a pinkish or light brown color. If conception is planned, this sign should not cause concern, but with a fairly long break in intimate relationships, it may indicate the development of inflammatory processes in the reproductive system;
You may experience mild pain in the lower abdomen that has a pulling nature, as well as a slight tingling sensation in the mammary glands;
a feeling of nausea, especially pronounced in the morning;
the appearance of a metallic taste;
short-term low-grade fever (increase in body temperature to 37.5 degrees);
emotional lability – a woman during this period begins to react very sharply to any external stimulus;
periodic attacks of dizziness, development of general weakness.

You should be attentive to any signs that may indicate that the embryo has attached to the wall of the uterus, because this period is considered one of the most dangerous throughout pregnancy. Any psycho-emotional overload can provoke a breakdown. In addition, it is necessary to carefully monitor the appearance of genital discharge and its characteristics. If they are bloody, profuse and last more than 2 days, you should consult a gynecologist.

Unfortunately, there are no obvious symptoms that the embryo has implanted in the uterus. In rare cases, a woman may have slight discharge and pain in the lower abdomen, but these symptoms are short-lived. Basically, the fertilized egg implants painlessly and almost imperceptibly.

Heavy bleeding and acute pain indicate hormonal problems and require immediate consultation with your doctor. They interfere with the normal development of pregnancy and require increased medical attention. During the process of attachment of the fertilized egg to the uterus, a woman may be irritable, emotional and feel a slight weakness in the body.

Women are often interested in what day the symptoms of the attachment of the fertilized egg to the uterus begin. Most women feel nothing. Embryo implantation is painless. Not everyone is able to notice an increase in the concentration of hormones in the body.

Rarely, but symptoms can be felt, here are some of them:

The stomach hurts and pulls below. Read more about nagging pain in the lower abdomen during IVF here.
Slight tingling in the chest.
During the first week there may be some discharge similar to menstruation. The discharge may be red, pink, brown or yellowish in color.
Nausea (especially in the morning).
Sometimes increased body temperature (not higher than 38).
Severe irritability.
Weakness.
Dizziness.

What can you feel during embryo implantation week by week?

These are the most common sensations at the beginning of the attachment of the embryo to the wall of the uterus (endometrium). This stage of pregnancy is very important, like all subsequent ones, but implantation is the most dangerous period for the embryo. It is important to maintain the right attitude, not to be nervous, and to avoid stressful situations.

7 weeks after attachment

During IVF, after embryo transfer, the same symptoms are observed as in a normal pregnancy. Watch the video for transfer tips. In this video, a reproductive specialist will talk in detail about what happens after transfer during in vitro fertilization.

Embryo implantation

Implantation is the process of “ingrowth” of an embryo into the uterine mucosa. After this, pregnancy occurs and the fertilized egg begins to develop.

With natural fertilization, embryo implantation is possible after the fertilized egg passes through the fallopian tube and enters the uterine cavity. Embryo implantation during IVF occurs after the procedure of transferring it into the uterus.

On what day does embryo implantation occur?

Pregnancy after IVF occurs only if the embryo has been implanted. It is impossible to say exactly on what day this happens, because the process of implantation of the embryo into the endometrium takes a certain time.

Reproduction doctors calculated how long embryo implantation takes and found that the duration of this process is about 40 hours. However, this is an average duration. There is no strictly limited time period during which embryo implantation will continue.

It is impossible to find out on what day the “introduction” of the blastocyst into the uterus should be considered complete, since this is a gradual process, not a one-step process. It can take from several hours to several days.

After implantation of the embryo, pregnancy occurs. This can happen at different times. Usually - on the 6-7th day after ovulation, respectively, on the 2-3rd day after the transfer. Sometimes there is late implantation of the embryo. In this case, the “ingrowth” of the blastocyst into the uterine mucosa occurs on the 10th day after ovulation or later.

If the IVF procedure is successful, the fertilized egg begins to produce hCG, and very soon the pregnancy can be established in the laboratory. The uterus begins to enlarge after implantation of the embryo. By its size you can judge the timing of pregnancy.

Conditions for embryo implantation

There are certain conditions under which embryo implantation after transfer is more likely to occur. These include:

endometrial thickness – optimally it should be 9-11 mm, minimum – from 7-8 mm;
normal blood circulation in the uterine mucosa;
normal levels of sex hormones in the blood, primarily progesterone;
woman's age is up to 35 years.

Implantation window offset

During one menstrual cycle, a woman has several days when the blastocyst is able to take root in the uterine cavity. This period is called the implantation window. The search for methods for determining the implantation window is still ongoing. A method for determining the expression of more than 200 genes in the endometrium has become widespread. By studying these genes, scientists can determine the period during which an embryo can take root in the uterus.

In women with repeated unsuccessful attempts at in vitro fertilization, a shift in the implantation window (earlier or later than expected) was detected in 25% of cases. Taking into account and using this information in practice, reproductive specialists receive in 50% of cases the fact of pregnancy in women with repeated unsuccessful cycles.

Embryo implantation after IVF transfer. What is late implantation

Will the transferred egg fall out after replantation? What are these? These questions are the most common among future IVF mothers.

We will look at what is necessary for full blastocyst implantation, what to do to make it happen, and the differences between embryo implantation during IVF.

Implantation conditions
Features of implantation in IVF protocols
When does embryo implantation occur after transfer?
The immune system
Medication support
Signs of embryo implantation after transfer. Symptoms
Can embryos fall out?

Conditions for implantation during IVF

The mechanism of embryo implantation after transfer (during IVF) is theoretically no different. The process is little studied even in natural cycles. It is known that it can extend over time and consists of two main phases: adhesion and adhesion (or penetration).

Necessary conditions for success:

Active. Provided with the preparedness of the cells of the uterine mucosa.

Produced on time.

Reproductologists have such a concept as an implantation window. This is the period during which the uterus is able to interact with the embryo. The implantation window is limited in time, so the effectiveness of IVF largely depends on the timeliness of transfer to the uterus.

The peak of receptivity - the ability of endometrial cells to interact with the embryo - occurs on days 20–21 of the cycle, but can shift depending on the drugs used for stimulation, the body’s sensitivity to them and the duration of the menstrual cycle. Most often, the implantation window opens at 20-21 days in the natural cycle, with controlled stimulation of ovulation - at 19-20, with hormone replacement therapy - at 21-22 days.

In addition, IVF is characterized by a lengthening of the interval during which implantation occurs - it lasts up to 3 days. Normally the process lasts 40 hours.

Late implantation does not affect pregnancy outcome. But defective implantation of the embryo after transfer is a common cause of spontaneous abortion.

When does embryo implantation occur after transfer?

It is reliably known that embryo implantation occurs after transfer, when hatching is completed. After transferring three-day-old embryos at the morula stage, initiation of implantation occurs 2–3 days after transfer (2 and 3 DPP). After - on the same day or the next day.

The immune system

The role of the immune system in the implantation process has not been thoroughly studied. It is certain that it has an impact. Pregnancies after IVF are associated with the presence of antithyroid, antiphospholipid antibodies, activated natural killer cells - NK in the blood serum of women.

For a long time it was believed that the immune system is suppressed so that there is no conflict between the mother’s body and the protein molecules of the embryo. Scientists have proven that cellular interactions actually occur and become more complex. The appearance of atypical reactions leads to implantation disorders at the stage of adhesion and invasion.

Reasons for the absence or failure of implantation

There are several reasons why embryo implantation after transfer

becomes unsuccessful:

. The reason is a poor-quality genome formed during fertilization.
Endometrial receptivity is impaired. Causes – consequences of infectious inflammatory processes, hormonal regulation disorders.
The embryo cannot get rid of the thickened protein membrane on its own. This often occurs in older patients and is associated with. Other reasons are embryo transfer after ovulation, prolonged hormonal induction of ovulation, disruption of endocrine organs, smoking, embryo cultivation in an artificial environment.

What can prevent the embryo from implanting?

It is best to plan and properly prepare for a future pregnancy so that the implantation of the embryo is successful. Pregnancy will go smoothly, without any troubles, if you are ready for it.

Reasons why the fertilized egg may not attach:

Embryo implantation may not occur after a previous abortion, miscarriage or pelvic inflammation.
Taking hormonal drugs and subsequent hormonal imbalance.
Use of an intrauterine device.
Maternal malnutrition.
Bad, destructive habits.

For proper preparation, visit a gynecologist. He will create a preparation program for pregnancy. As a result of preparation for conception and pregnancy, the risk of such negative factors can be avoided.

Signs of embryo implantation after transfer and symptoms

Individual sensations – dizziness, metallic taste, weakness, malaise, increased basal and general body temperature and others are difficult to attribute to symptoms of embryo implantation after transfer. They may be associated with previously performed progesterone, prescribed to support implantation, or the result of “soul-searching” - looking for signs of an upcoming pregnancy.

A significant sign of embryo implantation after transfer is implantation bleeding, which is rare. It can easily be confused with spotting that occurs due to insufficient luteal phase support. Therefore, only your Mr. can judge the nature of their origin.

Can the lower abdomen hurt a lot during implantation?

If you're trying to get pregnant, the time between ovulation and when you can use a home pregnancy test can seem like an eternity.

Cramping and pain can be one of the symptoms of embryo implantation, but sometimes it can be a problem.

Can embryos fall out?

Nature is wise, embryos do not fall out either after artificial transfer to, or to.

Inside the uterus - on the mucous membrane - there are many villi. As soon as the embryo comes into contact with them, they envelop and hold it. In addition, the uterus is a hollow organ, but its walls are adjacent to each other. Once hatching has occurred, the exposed embryo adheres. The outer cell mass surrounding the embryo is very sticky.

In conclusion, watch the video - the opinion of a specialist obstetrician-gynecologist-reproductologist, Ph.D. Kamenetsky Boris Aleksandrovich about whether embryos can fall out of the uterine cavity.

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