Effective hormonal treatment for uterine leiomyoma will be provided by Buserelin depot. The drug in the form of injections changes the endocrine background in a woman’s body, suppressing the growth of myomatous nodes and preventing the deterioration of the tumor process. The drug is used according to strict indications and with mandatory medical supervision. It is necessary to carefully and carefully follow the recommendations of a specialist, because Buserelin Depot has a strong effect on the hormone-producing structures of the brain. Reviews from women who received long-term hormone therapy with an injectable drug indicate a positive effect on leiomyoma and side effects during treatment with the drug.
Properties of the drug
Buserelin Depot is a medicine created for the treatment of endocrine diseases in women and men. The basis of the synthetic drug is a substance similar to natural hormones produced by the hypothalamus. The medicine acts on the pituitary gland, increasing the concentration in the blood of the main reproductive hormones - FSH and LH. This effect on the endocrine background ensures a decrease in the concentration of estrogen and a decrease in the risk of growth of myomatous nodes.
The advantages of the drug include:
- rapid therapeutic effect for uterine fibroids;
- 1 injection per month is enough to get a good result;
- preservation of the main reproductive organ and reproductive function.
Buserelin Depot after intramuscular injection ensures a long-term supply of the drug to the blood and an effect on uterine fibroids for 4 weeks. Reviews from women show that course treatment helps to significantly reduce the size of leiomyoma and creates conditions for the dream of having a baby to come true.
It is important to listen to the doctor and do everything correctly in order to provide therapy for the muscle tumor and preserve the ability to conceive and bear a fetus.
Reviews from doctors
“Buserelin is a fairly strong and effective antitumor drug. Reviews from patients often describe it as a good drug. However, there are a number of people who have noted the development of various side effects.
As a rule, patients tolerate Buserelin more easily in the form of a spray. Almost all women while taking the drug note signs of early menopause. However, it is only in rare cases that the cycle is not restored.”
“I have been prescribing Buserelin to my patients for several years. This drug copes with myomatous nodes quite quickly and effectively. This drug is also quite effective in treating fibroids in most women.
Indications for therapy
Buserelin Depot is actively used by doctors for the following types of gynecological pathologies:
- uterine leiomyoma;
- endometriosis;
- hyperplastic processes of the endometrium with a high risk of oncopathology;
- breast tumors;
- infertility.
The drug is used strictly according to indications: you cannot use injections of a strong hormonal agent yourself. Medical control involves regular visits to a specialist, ultrasound screening and hormonal examination.
Buserelin: what types of drug are there?
The hormonal balance in the human body is controlled by the brain: a special gland (hypothalamus) produces special substances (releasing factors) that act on most of the endocrine glands. With endometriosis, it is necessary to take into account the influence of estrogens - the more there are, the more severe the symptoms and the greater the risk of spreading endometrioid disease. Buserelin is one of those drugs that can suppress hypothalamic releasing factors and create conditions for reducing the production of estrogen. Typically, doctors use the following drug options:
- Buserelin-Depot;
- Buserelin-Long;
- Buserelin acetate in the form of a nasal spray;
- Goserelin.
Any type of drug provides a lasting therapeutic effect, but reviews from doctors show that it is better to give preference to the original drug (Buserelin-Depot).
Contraindications
As reviews from doctors show, long-term treatment cannot be carried out for large uterine fibroids. Buserelin Depot is often used at the 1st stage of combination therapy: after a short course of injections, the size of the muscle tumor decreases, which allows surgery to be performed with a lower risk of complications. Hormone therapy is contraindicated in the following conditions:
- malignant neoplasm requiring surgical treatment;
- pregnancy and lactation;
- allergic reactions;
- severe liver and kidney diseases.
It is necessary to carry out treatment with caution when the number of complications that manifest themselves through neurological symptoms increases.
Advantages of the medicine
The undoubted advantages of treating endometriosis with Buserelin-Depot are:
- high efficiency, which is associated with a guaranteed decrease in the level of estrogen in a woman’s blood;
- ease of use (monthly injection);
- no effect on body weight;
- no negative effect on metabolism;
- no risk of thrombosis and vascular complications;
- the woman will not have an increase in hormones with androgenic effects (no seborrhea, acne and hirsutism);
- there is no dysfunction of the liver, kidneys or digestive organs.
In severe forms of endometriosis, the drug has a multifaceted positive effect, helping the doctor relieve the woman of many unpleasant symptoms of the disease.
Treatment regimen
Standard course treatment involves monthly injections. The doctor will prescribe Buserelin Depot 1 injection every 30 days at regular intervals. It is optimal to give injections in a medical facility, or injections can be given at home by an experienced nurse. Important conditions are compliance with the dosage of the drug and strict adherence to the method of administering the drug. The duration of course therapy is from 3 to 6 months. The doctor will use monotherapy or prescribe a course of injections in preparation for surgery.
Similar drugs:
- Clomifene Oral tablets
- Postinor Oral tablets
- Clomid Oral tablets
- Escapelle Oral tablets
- Serophene Tablets
- Nolvadex Oral tablets
- Nemestran Capsule
- Buserelin Nasal Spray
- Tamoxifen Hexal Oral tablets
- Faslodex Solution for intramuscular administration
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Buserelin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Buserelin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Side effects of long-term treatment
Buserelin Depot affects the functioning of brain structures - the pituitary gland and hypothalamus. Suppression of hormonal function provides a positive effect on uterine fibroids, but can cause the following unpleasant manifestations:
- headache;
- sleep problems;
- emotional disorders in the form of depression, nervousness, irritability;
- periodic heavy sweating due to vascular reactions;
- acyclic uterine bleeding in the form of unsystematic, scanty periods;
- decreased sexual desire;
- severe vaginal dryness with itching;
- negative effect on mineral metabolism with a decrease in the amount of calcium in the bones;
- allergic reactions.
Reviews from doctors are clear: Buserelin Depot has a pronounced effect on the hormonal balance of the female body, forming an artificial and reversible menopause. All unpleasant symptoms caused by injections are due to the suppression of endocrine functions in the female reproductive system and the effect on the activity of brain structures.
The technique is simple and effective - the woman makes deep intramuscular injections monthly, following the recommendations of a specialist. During the first 1-2 months, side symptoms are possible - headaches and menstrual irregularities. Then the situation will get better: there will be no menstruation, and neurological manifestations will become less pronounced. Buserelin Depot is a highly effective method of hormonal therapy for uterine leiomyomas, which allows you to prevent the growth of muscle tumors and maintain fertile function.
treatment of endometriosis with buserelin
Hello everyone. I immediately ask you not to judge strictly, everything that will be written here, first of all, I am writing this for myself, to speak out, to realize that sometimes it’s so hard to keep everything to myself ((((I’ll start with the fact that I’m 24 years old, My husband and I have been together for 6 years (married for 2 years). At the age of 16, I started having problems, I had severe stomach pain, an ultrasound was done at a local clinic, and I was diagnosed with an ovarian cyst, this is where my story begins. From the age of 16, every year I had “climbs” cyst of the left ovary, one doctor treated and undertreated, another, I was observed by different gynecologists, every year I was in the gynecology, but the result was the same!!! At the same time, all the doctors unanimously insisted that the situation was not critical, it was not worth operating (you I haven’t given birth yet, we’ll watch), but at the same time these gynecologists hammered into my head that “yes, conceiving a child will be difficult,” and I forgot to say, in addition to the cyst, I also have chronic adnexitis (it seems so). And so My husband and I decided that it was time to give birth to a baby, but it didn’t work out that way, unfortunately (((the first month, the second, the third, after 4 months I panicked, I remember everything that the doctors said about possible consequences and infertility. C With every attempt, I become more and more fixated on infertility, nerves, stress. We looked for good gynecologists and found them! In general, she sucked so much money out of me, I took 20,000 thousand tests alone, not counting paid appointments, etc., but money not the main thing, I need a result, but there is no result ((again tears, snot, I’m so tired, etc. and then this gynecologist sends me for an x-ray of the fallopian tubes (after 8 months of observation), the diagnosis is obstruction of one tube! I am by nature , I always take everything to heart, so to find out the diagnosis, I didn’t even think about the fact that even with one tube they get pregnant, and that everything will be fine, no, I’m hysterical, I’m depressed. Thanks to my husband, he supports me, but we there is an 8 year difference between him and me, he is now 32, won’t he leave for someone else in a year, another if I still don’t give birth - this thought ate me up, although my husband says he won’t leave)) I got distracted (after such a diagnosis, a local clinic gave me a referral to the Family and Child Planning Center in the regional center, for further eco. And tests and examinations began again, and when all the tests were completed, I was sent for a consultation with a gynecologist-surgeon. In turn, she spent a very long time looking at my x-rays of the uterus “I doubt it.” “that you have an obstruction here, here you can barely see a trace, most likely the time of the photo was delayed and the contrast leaked out” for me this news was like thunder, it seemed like wonder and rejoice, but no, “I’ve been through so much, I’m so poor, unhappy, I’m it was built that everything is bad, but here it’s good” in short, I’m a fool!!! In general, the surgeon suggests doing a diagnostic laparoscopy, looking from the inside, and if something happens, eliminate the cause, and there will be no need for IVF. Literally two weeks later they do a lapara, in general the cyst was removed, adhesions, and ENDOMETRIOSIS and ENDOMETRIOID CYST!!! for many years, not a single doctor did an ultrasound or tests, I even did an MRI, but no one saw that the cyst was endometrioid, that it’s getting bigger, and that it’s hard to treat!! after lapara, I’m prescribed a buserelin injection, an artificial menopause begins, for six months it’s either hot or cold, aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaarghghly it was like that, I still cringe when I remember, but I’m ready to endure everything, for the sake of my unborn child))) and now, after 2 years of wandering around hospitals, treatment, tests, a long-awaited pregnancy)))))
Application
The use of the drug is prescribed individually, taking into account the clinical picture of the patient’s disease, as well as her age.
1-2 stages
For stage 1-2 endometriosis, the specialist prescribes 6 injections once a month. After three to four months, you can already notice a positive effect:
- reduction in the amount of discharge;
- reduction of pain in the lower abdomen, as well as during sexual intercourse;
- preventing the spread of endometrial cells to healthy organs;
- improving the general condition of the body, which significantly improves a woman’s quality of life.
3-4 stages
For severe forms of endometriosis, the specialist prescribes 3 injections, and then surgery is performed to excise the pathologically altered tissue. When taking Buserelin:
- the patient's condition improves significantly;
- the size of pathologically altered tissues decreases;
- the risk of bleeding during surgical procedures is reduced, and the likelihood of complications is minimized.
Leiomyoma
The prescription of the drug depends on the patient’s condition. If the disease is in a mild stage - 3 injections once a month, followed by switching to other medications, severe - 6 injections, and then surgical intervention.
Hyperplasia
When this pathology develops, the specialist prescribes 6 injections. As the injections are administered, every month, you can notice an improvement in the patient’s condition:
- reduction of uterine bleeding;
- prevention of malignancy of endometrial cells;
- therapy for iron deficiency anemia.
Rehabilitation
As a rule, after surgery, the doctor prescribes 3 injections of the drug over 3 months. The use of Buserelin allows you to reduce the risk of developing a relapse of the disease, as well as completely eliminate the occurrence of complications after surgical procedures.
ECO
The selection of the drug dosage regimen depends on the patient’s condition. Buserelin has the following effect on the body:
- prepares the uterus for implantation of a fertilized egg;
- promotes the maturation of several follicles at once.
