Proginova when planning pregnancy: reviews and instructions for use

What is this drug?

"Proginova" is an estrogenic drug that can compensate for the lack of its own hormones in the female body. It is often prescribed to women during menopause to relieve unpleasant symptoms such as insomnia, hot flashes, and severe sweating.

In addition, the drug protects against the development of osteoporosis, which also becomes a pressing problem during menopause. It has been established that the medicine copes well with other problems. For example, it is used for endometrial growth if this reason does not allow a woman to bear a baby.


The product is produced in the form of dragees, packaged in blisters of 21 pieces. The main active ingredient is estradiol valerate in an amount of 2 mg. In addition, there are additional components:

  • Lactose monohydrate.
  • Corn starch.
  • Magnesium stearate.
  • Macrogol.
  • Sucrose.
  • Calcium carbonate.
  • Glycerol.
  • Titanium dioxide.

Supplied to pharmacies in cardboard packs.

Positive effect of the drug

The drug helps solve some gynecological problems, but compared to other drugs it has a number of advantages:

  • Does not suppress the production of its own hormones by the endocrine glands.
  • Ovulation is not suppressed.
  • Effectively replenishes estrogen deficiency in the female body.
  • Eliminates many symptoms of menopause.
  • Bone tissue is being restored.
  • There is growth of the endometrium, which has a positive effect on a woman’s ability to bear a baby.

If problems arise, you should visit a doctor, who will prescribe therapy. You should not take the drug on the advice of friends and acquaintances.

Proginova for endometrial growth

The diagnosis of endometrial hypoplasia is made to every fourth woman who consults a gynecologist about the lack of pregnancy. This problem is accompanied by scanty menstruation, lack of ovulation and irregular cycles. To treat small endometrium, hormonal therapy is used, which includes the schematic use of Duphaston and Proginova.

Need for expansion

Doctors see the need for artificial extension of the endometrium when a woman unsuccessfully plans a pregnancy, and an examination shows insufficient thickness of the inner layer of the uterus.

In this state, the probability of natural conception tends to zero. In order to normalize the thickness of the uterine mucosa, various combinations of hormonal drugs are used.

Often the choice of a specialist falls on Proginova and Duphaston - time-tested drugs.

Increasing the inner surface of the uterus for embryo attachment is mandatory before in vitro fertilization and is often recommended for intrauterine insemination. Previous hormonal therapy allows you to obtain effective results from assisted reproductive technologies and reduce the likelihood of failure.

The consequence of frequent growth of the mucous layer can be hyperplasia.

Mechanism of action of Proginova

Proginova tablets for growing the endometrium are prescribed in cases where hypoplasia is caused by estrogen deficiency. The drug stimulates the production of estradiol, a hormone of the female reproductive glands.

As a result of taking it, blood circulation in the uterus improves and the ovaries begin to work. Proginova is recommended for use as a cyclic regimen or continuously.

The treatment method is selected in accordance with individual characteristics and the goal of the final result.

Enlargement of the endometrium in case of hypoplasia must be carried out. Even if pregnancy occurs with a thin mucous layer, it will be terminated with a high degree of probability. Throughout the entire period, the woman will be faced with worries and threats of miscarriage.

Due to insufficient blood supply to the placenta, congenital pathologies of the fetus may occur.

To avoid all these problems, gynecologists prescribe Proginov tablets to planning women, which must be taken within three weeks from the end of menstrual bleeding.

The medicine is taken once a day. Proginova for building begins to be taken on the 5th day of the menstrual cycle. It is advisable to consume the pills after meals. For 21 days, the hormonal medication is regularly used at the same time.

Duphaston's appointment

The drug Duphaston is a supplier of progesterone to the patient’s body. It is used when extending the endometrium of Proginova in order to maintain the second phase. Duphaston is not recommended for all planning women. The doctor makes the decision to prescribe it after examining the patient: an ultrasound examination of the condition of the corpus luteum and a blood test for progesterone.

The endometrium of the uterus and the drug Duphaston do not have a direct relationship. The hormonal agent has only an indirect effect on the structure of the mucous membrane of the reproductive organ. Unlike the drug Proginova, which is used for extensions, Duphaston works differently. Dydrogesterone, which is part of the medication, supplies the body with the missing progesterone.

Thus, the medication normalizes uterine tone and prevents abortion. Often this remedy is used when there is a threat of miscarriage, after the endometrium has grown and fertilization has occurred. Indirectly, dydrogesterone affects conception and increases the likelihood of implantation of the fertilized egg. The drug loosens the endometrium, making it softer. This makes the implantation process easier.

Tablets are prescribed to women 1-4 tablets per day. The selected volume should be divided into 2 doses. It is important to consume the second phase hormone at regular intervals to avoid sudden jumps in progesterone levels in the body. For women with a stable 28-day cycle, Duphaston is prescribed from the 16th day. In other situations, the timing of use of the drug is discussed with the doctor.

You should make sure that ovulation has taken place and only then take a progesterone-based drug. If you start using it earlier, the medicine can suppress the release of the egg and have a contraceptive effect, despite the diligent growth of the endometrium.


The consequences of using Proginova and Duphaston are not long in coming, quickly showing positive results. Patients form positive reviews about this regimen of taking hormonal drugs.

Most women with thin endometrium were able to get pregnant in the first three cycles. The likelihood of a positive outcome from IVF and insemination also increases with the use of hormonal pills.

If pregnancy did not occur, then women noted the regularity of the cycle, as well as the normal volume of menstrual blood, which indicates the effectiveness of mucosal growth.

Medicines Proginova and Duphaston are included in the list of prescription pharmaceutical products; self-medication should be excluded.

These medications should be prescribed by a doctor, taking into account the individual characteristics of the female body and only after a detailed examination, including a blood test for hormones.

An important point is to exclude estrogen-dependent tumors of the mammary glands and endometrium. Before taking medications, you should make sure that there are no contraindications to hormonal therapy.


Contraindications and side effects

If there is a need to take the drug, its use is not always permitted. The following conditions and pathologies are contraindications:

  • Breast oncology.
  • Vaginal bleeding of unknown nature.
  • Neoplasms in the liver.
  • Thrombosis or thromboembolism.
  • Severe liver pathologies.
  • Lactose intolerance.
  • The period of bearing a baby.
  • Hypersensitivity to the components of the drug.
  • Age up to 18 years.

Therapy with Proginova can lead to the development of the listed diseases, therefore, if unpleasant symptoms appear, treatment should be stopped.

Negative symptoms when taking the drug may be as follows:

  • Headache and dizziness.
  • Spotting vaginal discharge.
  • Breast tenderness.
  • Increased heart rate.
  • Muscle spasms are rarely observed.
  • From the digestive system, abdominal pain and nausea may appear.
  • Change in body weight.
  • Mood lability.
  • Swelling.

In rare cases, taking the drug resulted in malignant neoplasms in the liver and intra-abdominal bleeding, which was life-threatening for the patient.

The development of pathological changes is directly influenced by the duration of therapy, so use should be carried out only as prescribed by a doctor and according to the recommended regimen.

How to use?

Proginova should be taken for the growth of the uterine mucosa only in the dosage prescribed by the doctor. The treatment regimen may vary:

  1. The course is cyclical. With this regimen, it is recommended to take one tablet daily for 3 weeks, and then a 7-day break. Then the course is repeated. The number of repetitions depends on the effectiveness of the therapy.
  2. Continuous use involves therapy for a long time without a week's rest.

Depending on the severity of the pathology, the doctor may change the dosage of the drug, for example, take 1 tablet for the first week, and then the dosage increases to 2 or 3. The effectiveness of therapy is monitored using ultrasound and adjusted if necessary.

What is Prolignova

Prolignova is a hormonal drug that contains estradiol valerate, which is a synthetic analogue of the hormone estradiol produced by the ovaries. The drug also contains estrogens.

Why is Prolignov prescribed? When planning pregnancy and stimulating IVF, the drug helps to compact the endometrial layer of the uterus to securely secure the fertilized egg. Prolignova has a positive effect on the estrogen levels of the body without affecting the production of other hormones.

The drug is prescribed in the following cases:

  • if previous pregnancies did not go smoothly or were interrupted;
  • in case of hormonal imbalances in preparation for pregnancy;
  • if necessary, “grow” the internal tissue of the uterus (endometrium);
  • if necessary, stimulate the placenta and improve its blood circulation.


You can buy the medicine with a doctor's prescription at the pharmacy. The drug is not in short supply, so there are no problems with acquisition. The price may vary at different points and ranges from 400 to 600 rubles.

For every woman, the most important thing is to become a mother. But nowadays, the diagnosis of infertility has become not so rare. A complete examination will reveal the cause of the inability to get pregnant, and then effective therapy will be prescribed. It is very important that a woman understands that treatment can be lengthy and its success depends on how well she follows the doctor’s recommendations. If it’s all about the thin endometrium, then “Proginova” will successfully correct the situation for the better.

Side effects of Proginova

The following side effects are possible:

  • problems with the stomach, intestines and other gastrointestinal organs (flatulence, diarrhea, nausea, etc.);
  • sensory organ disorders (depressive states, dizziness, insomnia, etc.);
  • disorders of the cardiovascular system (tachycardia, etc.);
  • allergic reactions (swelling, urticaria, rash, itching, etc.);
  • disorders of the reproductive system (menstrual irregularities, discomfort).

If these or other side effects of the drug are detected, it is necessary to interrupt the cycle of taking it and immediately consult a doctor.

No cases of overdose have been identified.

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