In gynecology, there are often cases where a girl cannot become pregnant due to lack of anovulation. In this situation, it is necessary to stimulate the maturation of the female cell. There are many ways to stimulate the release of an egg. But in some cases you can cope with this by simply using vitamins for ovulation, and in some cases surgical intervention will be required.
What is ovulation stimulation
CO is a technique with the help of which 70% of girls can become mothers. The specialist begins therapy with vitamins to stimulate ovulation for unknown reasons for the unripeness of the egg, its absence or defective development.
Gynecologists prescribe treatment with hormonal drugs in the presence of female diseases and other related ailments.
It is recommended to take medications to stimulate the ovaries after a year of unsuccessful regular attempts to conceive naturally. For older couples - after six months.
General dosage regimen
Vitamins do not directly affect ovulation and do not treat pathologies that cause an anovulatory menstrual cycle. They activate the endocrine and reproductive systems, which contribute to the normal maturation and release of the egg. The dosage regimen depends on the phase of the monthly cycle. The therapeutic course is 3 months.
The generally accepted scheme for using vitamins for stimulation:
- from the first day of menstruation for 14 days - retinol, folic acid, tocopherol;
- from the second half of the menstrual cycle - ascorbic acid, vitamins from group B (Pentovit and others), E.
The list of drugs, regimen and dosage are adjusted by the doctor individually after examining the patient. It is not recommended to use without a doctor's prescription. Lack and excess of the substance equally harms the body, negatively affects the regularity of the cycle, and suppresses ovulation.
Vitamins and their benefits for active ovarian function
Representatives of the fair sex who are planning a pregnancy must replenish their body with useful substances. To do this, it is better to consult a gynecologist. It will help you create the right diet that covers your daily requirement of useful elements.
The specialist will select complex procedures that are most suitable for the woman.
A lack of required components can cause embryo pathology. The situation can be avoided by regularly taking iodized salt and folic acid.
Nutritionists advise adding to your diet:
- fresh berries;
- fruits;
- vegetables;
- greenery;
- boiled or stewed fish;
- Minimize the consumption of coffee and strong tea.
Vitamin A
Retinol promotes the growth of a healthy follicle, normalizing the amount and composition of cervical fluid. Vitamin A is recommended to be taken before ovulation. They continue to drink it in the absence of pregnancy and the beginning of menstruation.
What are the reasons for the lack of ovulation?
Ovulation is the best period for the desired fertilization. At this time, under the influence of certain hormones and changes in the female body, the follicle ruptures and the egg is released from the ovary. She is completely ready for possible conception.
Often, the absence of ovulation is not accompanied by any extraneous signs. Girls often find out about the violation only if they want to get pregnant. An anovulatory cycle also occurs in completely healthy women up to 2 times a year.
The main causes of the anovulatory cycle are presented in the table.
| Infectious-inflammatory diseases | Prolonged absence of ovulation can be provoked by: • chronic salpingoophoritis; • polycystic ovary syndrome; • cystic formations; • benign or malignant neoplasms. |
| Body mass | The disorder is usually encountered by girls who have a small body weight, usually up to 48 kg. In this case, there is insufficient production of the required hormones. |
| Hormonal changes | Hormonal disorders occur under the influence of regular stressful situations and excess body weight. This is also possible with some thyroid diseases. |
| Medicine | The culprit of the pathology may be long-term use of hormonal contraceptives. In this case, ovulation may not occur for several months. |
| Physical exercise | Another cause of the disorder is excessive physical activity. The condition especially worsens if the girl additionally takes various sports supplements. |
Ovulation failure is also not uncommon among women who regularly find themselves in stressful situations.
Nutrition also plays an important role. The disorder is encountered by women whose diet includes:
- fat;
Disorders can occur when eating junk food
- fried;
- pickled;
- sauces;
- spicy;
- spicy;
- alcoholic drinks.
Smoking also has a negative effect. Among smokers, there are more women who experience impaired egg maturation and release. Sometimes, to normalize the condition, it is enough to review the diet and give up bad habits.
Only a doctor can determine the true cause of failures after conducting a comprehensive diagnosis. You need to see a doctor as soon as possible.
Vitamin E
Tocopherol affects the normal course of the cycle.
Its deficiency can cause a delay in follicle maturation. It helps the egg grow and form. Vitamin E prevents spontaneous abortion. It is taken in the first phase of the cycle. After 2-6 months, the possibility of conception increases. The patient needs to resume its use after fertilization, because it suppresses the contractions of the uterine muscles.
Active planning blog
Zinc 15 mg
During IVF stimulation, you may need more zinc to support the maturation of many oocytes at once (40-50 mg/day).
Take before conception and during pregnancy. It is essential for the rapid development of the egg within the follicle, especially in IVF when many eggs are developing simultaneously. Helps prevent miscarriage. 82% of pregnant women worldwide are zinc deficient
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Vitamin A
Before conception and during pregnancy. Promotes the production of cervical fluid. Helps follicles mature properly. Contains important antioxidants. Important for DNA replication.
Vitamin E 200 IU
take before conception. Improves the quality of yak
L-arginine 500 mg - 2000 mg per day.
Take 1-3 months before conception. Improves the quality of UC and blood flow in the uterus.
Co Q10 / Enzyme Q10:. 200 mg - 600 mg ubiquinone / 50-100 ubiquinol. during or after lunch
Take before conception and during pregnancy - but reduce to a maximum dose of 200 mg during pregnancy. Improving the quality of UC due to a powerful effect on the regeneration of mitochondria - the tiny energy factories of each cell - is known to be a factor in age-related infertility. Reduces the risk of preeclampsia.
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DHEA: 25 mg three times daily = 75 mg total
Improves the quality of UC in women over 40 years of age with reduced ovarian reserve. DHEA must be micronized.
Inositol: taken at night for 1-3 months before conception.
Helps restore fertility in women with PCOS. 2000 mg per day. Take 3 months before conception. Improves the quality of UC at 3000 mg per day,
Glutathione. At a dose of 600 mg per day, it reduces homocysteine.
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N-acetyl-cysteine (NAC)
N-acetyl cysteine is one of the best ways to increase intracellular glutathione, the main antioxidant for fertility and PCOS. Glutathione has an anti-inflammatory effect and protects the cells of our body from oxidative stress, and the cells of the growing follicle in the ovary from damage.
Melatonin: 2-3 mg per day, taken strictly at night, because... causes drowsiness.
Take for 1-3 months before conception. Improves the quality of UC by reducing the level of the oxidizing agent 8-OHdG.
Selenium:. 100 mcg twice daily = 200 mcg total.
Take before conception and during pregnancy. Promotes implantation, prevents miscarriage. Promotes the production of glutathione.
Omega-3 Fish Oil (Omega 3 oil/Essential fatty acids): 200 mg – 1000 mg fatty acids per day.
Take before conception and during pregnancy. Anti-inflammatory. Improves blood supply to the uterus, thins the blood. Reduces the activity of NK cells,
Vitamin C:. 500 mg
Take before conception and during pregnancy. Correction of luteal phase defect, because increases the level of progesterone and estrogen. Improves pregnancy rates and helps prevent miscarriages.
Vitamin D:. 1500 mIU - 2000 mIU.
Take before conception and during pregnancy. The ideal level for improving fertility is 50 – 80 ng/ml of vitamin D in the blood. Vitamin D3 is the best form of the vitamin. Make sure you also take vitamin A and K to balance
Vitamin D, problems occur when you have too much vitamin D and too little vitamins A and K. Improves fertility. No more than 4000 mIU per day
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Iron 14 mg
Take before conception and during pregnancy, along with vitamin C for better absorption. Tannin slows absorption, so do not take with drinks that contain tannins, such as green tea. Research has shown that women who do not get enough iron may have anovulation and possibly poor egg quality, which can reduce the chance of pregnancy by 60% (!!!) compared to those who have adequate iron stores in their blood. .
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Magnesium - deficiency can lead to ovulation problems.
Take with Vitamin C (but note - it competes with iron for absorption) Essential to help the pituitary gland and ovaries produce the high levels of estrogen and progesterone needed to support pregnancy until the placenta takes over.
Vitamin B9 (folic acid) 400-800 mcg, preferably in the form of methylfolate.
high levels of homocysteine negatively affect the results of IVF and pregnancy.”
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B12
Royal jelly
Royal jelly is also a superfood that can help improve the quality and quantity of UCs.
Maca (1 capsule)
Maca is an incredible fertility superfood. Helps balance hormones, but does not contain any hormones itself. Maca is able to do this by nourishing and balancing the endocrine system. This is important in preparing for pregnancy and IVF because healthy hormonal balance greatly contributes to healthy UC.
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PQQ: 20mg/day
an antioxidant that protects against mitochondrial damage and promotes spontaneous regeneration of new mitochondria within aging cells.
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N-acetylcysteine (NAC)1500-1800mg/day
NAC acts to increase our cellular levels of glutathione, which protects the quality and health of UC by preventing damage to the ends of the egg's DNA (8,9). Additionally, NAC has potent anti-inflammatory effects (10), and has been shown in studies to promote ovulation in women with anovulatory PCOS (11, 12).
Contraindications for use
You should stick to the prescribed dosage of retinol. Excessive amounts of it can affect the child's health. After a course of therapy, it is recommended to abstain from conceiving for six months.
Avoid excess ascorbic acid in the body. It can cause B12 deficiency.
Do not trust an ovulation stimulation course to an unqualified doctor.
Choose multivitamins and buy ones designed for pregnant and breastfeeding women.
Self-medication is not recommended.
How does vitamin stimulation work?
Vitamin complexes are used to stimulate ovulation. Sometimes this is enough to completely restore the normal menstrual cycle. You can purchase medicines at any nearest pharmacy.
The diet must include foods rich in vitamins
Along with vitamin therapy, you need to eat right. It is required that the body receives its daily requirement of nutrients. This will help the therapy become more effective.
Vitamin therapy should continue for at least 2 weeks. The dosage and duration of treatment is selected individually. For stimulation, the doctor prescribes:
- vitamin D;
- ascorbic acid;
- retinol;
- vitamin E;
- vitamin B6;
- folic acid;
- Potassium iodide.
Vitamins must be supplied to the body in a comprehensive manner.
Vitamins are taken only as prescribed by a doctor. The recommended dosages must be strictly followed. To successfully conceive, it is imperative to lead a correct lifestyle. Only in this case the therapeutic course will be effective.
The dosage cannot be changed independently. This also applies to the duration of treatment.
Methods of procedure
As part of the activation of ovarian function, an integrated approach is practiced. It includes taking hormonal medications, vitamins and using traditional medicine. Efficiency is increased by adjusting nutrition.
Medication
At each stage of the menstrual cycle, certain medications . The remedies are selected based on the diagnosis. There is the following stimulation scheme:
- From days 5 to 9 of the cycle, pills are taken to stimulate follicle growth. Most often at this stage Clostilbegit is prescribed. The active substance of the drug is Clomiphene. The principle of action is based on the ability to increase the amount of estrogen.
- On days 10-12 of the cycle, an ultrasound is performed. If the size of the endometrium deviates from the norm, Divigel or Proginova is prescribed. The first drug is applied to the skin, and the second is intended for oral administration.
- On the 14th day, the ultrasound examination is repeated. When the size of the dominant follicles is from 18 mm, an injection of hCG is given: it provokes its rupture. Ovulation occurs 12-36 hours after the introduction of hCG into the body. The dosage is selected individually - from 5000 to 10 thousand units.
- Sexual intercourse is indicated immediately after the injection and after 36 hours. Recommendations may vary depending on the partner’s sperm count.
- 3-4 days after presumed ovulation, the ultrasound is repeated. If the corpus luteum and fluid behind the uterus are present, then the stimulation was successful.
- After confirmation of ovulation, medications containing progesterone are prescribed. Duphaston is indicated for internal use. It is taken one tablet up to three times a day. Utrozhestan can be inserted vaginally or taken orally. There are two types of dosage: 100 mg and 200 mg. After stimulation, 2 tablets per day of 100 mg or one tablet of 200 mg are prescribed.
- Two weeks after ovulation, a pregnancy test is performed. On the 7-10th day of egg release, an analysis will be indicative to determine the level of hCG in the body.
Indications - for whom is it performed?
This method annually helps tens of thousands of women find the joy of motherhood. First of all, stimulation is indicated for women with polycystic ovary syndrome, with various manifestations of their dysfunction, including age-related ones . Medical artificial stimulation of ovulation is usually not performed on women over 40 years of age .
A woman complains about the inability to get pregnant and consults a gynecologist. The doctor studies not only the condition of her reproductive organs, but also the characteristics of the menstrual cycle. Such diagnostics include mandatory monitoring of follicle maturation using ultrasound diagnostics.
If this examination shows that ovulation is not occurring, preparations for stimulation begin.
The main indication for drug stimulation of the ovaries is the absence of pregnancy for a year, provided that the spouses do not use protection and have regular sex life. If the spouses (especially the woman) are already 35 years old or more, then the period of waiting for conception naturally is reduced to six months.
The procedure is contraindicated for women suffering from fallopian tube obstruction : otherwise, an ectopic pregnancy may occur. Also, stimulation is not performed on patients with inflammatory processes in the ovaries and other pelvic organs.
Another indication for stimulation is the absence of menstruation due to hypothalamic-pituitary insufficiency.
The reason for the procedure may be preparation for IVF or intrauterine artificial fertilization - insemination. Doctors are usually quite successful in stimulating the functioning of multifollicular ovaries; there are also stimulation schemes for endometriosis.
In case of hormonal imbalances, when ovulation is often “late,” stimulation of late ovulation is carried out.
also indicated for women with significant metabolic disorders , which manifest themselves as obesity or, conversely, underweight, because with these conditions, a couple often cannot get pregnant on their own.
Possible consequences and complications
Stimulation is carried out with hormonal drugs, the impact of which on the female body would be wrong to underestimate. The induction itself during the cycle often causes painful and unpleasant sensations in women. Many people complain that the lower abdomen is tight and even that the ovaries hurt after stimulation. Almost everything is about hot flashes that occur in waves.
One of the most dangerous consequences of stimulation is superstimulation , in which follicle growth occurs so rapidly that hyperstimulation syndrome develops. Most often it can make itself felt for the first time 3-4 days after the start of induction.
If signs of such a pathology appear at a later date - after 7-10 days of the menstrual cycle, then the syndrome is quite severe, with vomiting, diarrhea, swelling of the limbs and face, a drop in blood pressure, and a sharp deterioration in well-being.
A woman may require qualified assistance in a hospital setting. Therefore, stimulation should be carried out by a doctor with extensive experience in reproductive programs, who can promptly monitor the processes occurring in a woman’s body under the influence of hormones and make correct and informed decisions.
How to Improve Egg Quality: 6 Factors Affecting Fertility
For the successful conception of a child, not only the quantity, but also the quality of eggs is important.
The reproductive cell must not have any defects. Poor quality oocytes are not suitable for fertilization and the woman becomes infertile. But even if the sperm connects with the defective egg, the embryo will not be viable. It will cease to exist in the early stages - it will stop dividing before it reaches the uterine cavity. We have practically no power to influence the quality of eggs. The process of oocyte maturation is hidden from view and obeys its own laws. All we can do is reduce the negative impact of the environment on the reproductive system.
A healthy woman has normal functioning ovaries, mature eggs and a high chance of conceiving a child.
Efficiency
In the first cycle, when ovulation is stimulated in a woman, approximately 15% of couples manage to become pregnant.
During the second and third cycles, the number of positive outcomes, when ovulation can be restored, reaches 70-75%. In general, the effectiveness of drug ovulation induction is estimated at 70-80%. This is the number of couples that are ultimately able to be helped to get pregnant naturally.
The rest come to the aid of IVF, ICSI and other assisted reproductive techniques and techniques.
Treatment with folk remedies
Our ancestors knew something about women’s health long before such concepts as “ovulation stimulation” appeared. However, experts tend to believe that in alternative medicine the theory of probability plays a big role - there is always a chance to conceive, and therefore drinking weed, in principle, will not hurt.
Modern doctors respect folk remedies for improving women's health, but warn against self-prescribing them.
Any alternative treatment should be discussed with your doctor so as not to cause harm.
There are also certain rules for folk methods of increasing ovulatory ability. For example, you should not take herbs at the same time as hormonal therapy with medications , as this can lead to ovarian hyperstimulation.
Herbs and roots for female fertility are not taken during menstruation , and treatment with them for more than 3 months in a row, as well as hormonal medications, is not recommended.
The principle of treatment in alternative medicine is exactly the same as in traditional medicine. In the first half of the cycle, herbal remedies are taken that help the growth and development of the follicle . This is sage - decoctions and essential oils, a decoction of rose petals, an infusion of plantain seeds.
In the second half of the menstrual cycle, after ovulation, traditional healers recommend taking boron uterus - this plant contains plant progesterone. Decoctions and infusions are made from it, according to the instructions for use, which are included in the pharmacy packaging with this herbal collection.
To achieve ovulation, a woman is advised to stop drinking alcohol, not abuse nicotine, and diversify her diet with foods that best affect the functioning of the ovaries. This is liver, lean red meat, sea fish, dairy products.
