How long does it take for pentalgin to work for abdominal pain?

The drug "Pentalgin" for menstruation: rules of administration, restrictions and price

Severe abdominal pain in women, accompanying PMS and menstruation, is a fairly serious problem in modern gynecology.
To solve this problem, patients use various medications, including pentalgin for menstruation. This medicine is recommended for the relief of various pathological manifestations of the cardiovascular system, many diseases of the central nervous system, and inflammatory processes. Specialists in the field of diseases of the female genital area also successfully use this medication.

Read in this article

Pregnancy and lactation

The drug is contraindicated for use during pregnancy.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Menstruation is a very important period in a woman’s life. But it can be very painful and can literally unsettle you. What to do in such situations? What can help get rid of pain in the lower abdomen, which prevents you from fully functioning and generally interferes with your life? Of course, you can endure the pain, but it's not worth it. It is recommended to take Pentalgin during menstruation. It will relieve pain and spasm in just a few minutes, and also give a feeling of relief. After all, it is so important in the modern world - to be healthy and confident.

Pharmacological subtleties of the drug’s effect on the body

In medical practice, this drug is most often prescribed to patients to reduce body temperature, relieve pain, and counteract the development of inflammation. The pronounced therapeutic effect of pentalgin is based on the simultaneous use of several components:

• The mainstay of the medication is naproxen. This substance belongs to the class of non-steroidal anti-inflammatory drugs and, due to its effect on the synthesis of prostaglandins in the body, has a pronounced analgesic effect.
• The non-narcotic analgesic paracetamol is also responsible for the relief of pain in various diseases. This medicine is well known to patients due to its very low threshold of allergic activity. Paracetamol is recommended by pediatricians to reduce body temperature in children from a very early age.
• A natural blocker of histamine receptors, pheniramine, is used in this complex as a stimulator of the action of the first two components. In addition to this property, the substance has pronounced sedative and calming effects.
• The medicine offered to women also includes drotaverine, which has a pronounced antispasmodic effect. Thanks to the latter, pentalgin is successfully used for menstrual pain.
• The fifth component of this drug is caffeine, which is considered essential for various vascular pathologies. It smoothly dilates the blood vessels of the heart and brain, enhances kidney function, and reduces tissue swelling by removing fluid into the vascular bed. Caffeine increases the absorption of naproxen and paracetamol into a woman’s body, which significantly enhances the analgesic and anti-inflammatory effects of these substances.

Thanks to its unique formula, pentalgin is widely used in medical practice and is included in the treatment regimen for many diseases.

Pharmacological properties of the drug

A strong drug, Pentalgin, is taken in many cases. It relieves toothache and headache, fights inflammation.

• Has an analgesic and anti-inflammatory effect.
• It fights not only pain, but also spasms.

It is turned to in cases where the effects of ordinary painkillers are not enough. After all, for the most part, they struggle only with external symptoms, and the spasms remain, continuing to cause discomfort. Pentalgin promises a long-term and complex effect. It is also important that it is not addictive and generally does not have any negative effects on the body.

Indications and contraindications for the use of the drug

The use of pentalgin in medicine is due to its constituent components. Where do specialists most often use the remedy?

Main indications for prescribing pentalgin

This drug is mainly used in the complex therapy of various inflammatory diseases. Upper respiratory tract infections, acute respiratory viral infections, diseases of the stomach and intestines respond well to treatment with pentalgin.

Usually the medicine is prescribed if inflammation of organs and tissues is accompanied by a rise in body temperature, swelling and severe pain. The list of such pathologies is quite wide, but in each case the use of the drug must be agreed with a doctor.

The drug works best if the peripheral nervous system is involved in the process of pain. Excellent results have been obtained in the treatment of various neuralgia, toothache, migraine and pain in the joints and muscles.

Since algodismenorrhea is a direct indication for the use of this drug, the answer to the question of whether pentalgin helps with menstruation will be positive.

Watch the video about algodismenorrhea:

Contraindications for use

But not all patients can use this medicine to reduce pain during menstruation. The drug is prescribed with extreme caution in the presence of the following concomitant pathology:

• Any diseases of the bronchi and lungs, especially those accompanied by attacks of bronchial asthma.
• Gastrointestinal diseases, in particular, chronic gastritis with increased secretion of gastric juice, peptic ulcer in the acute stage.
• Blood diseases with severely low hemoglobin levels.
• This drug is contraindicated in patients with chronic liver and kidney failure.
• It is not recommended to use pentalgin during menstruation for women with a history of traumatic brain injury.
• The drug is prescribed with special caution to patients with problems of the cardiovascular system. High blood pressure is a reason to avoid using this medication.

In addition, do not forget about possible allergic reactions when treating a pain symptom with this remedy. For any abnormalities, you should consult a doctor.

How to use medicine correctly during menstruation

In most cases, representatives of the fair sex independently try to reduce pain during PMS and menstruation by taking painkillers. This is a rather vicious practice, since the drug in question has a lot of limitations and side effects.

The time it takes for pentalgin to act during menstruation depends on the woman’s condition, her pain threshold and the dosage of the product used.

The annotation for the medicine recommends prescribing it to women for pain during menstruation, 1 tablet 2-3 times a day, while the daily dose should not exceed 4 tablets. The treatment cycle is usually 3 days; it is not recommended to use the medicine for more than 5 days.

What a woman needs to consider

The presence of five components in this anesthetic drug often leads to the fact that its use requires some caution on the part of the doctor and the patient. For example, the caffeine present in it can affect the psycho-emotional state of a woman.

PMS and painful periods already cause irritability and aggressiveness in patients, so this drug is designed to calm a woman’s nervous system. In this case, it should be remembered that pentalgin helps with menstruation, but at the same time it causes a decrease in concentration and attention, which is very important when driving and working with delicate instruments.

Laboratory tests of blood and liver function are required after 7 days of taking the medicine. Equally important is the control of the blood coagulation system, since naproxen, which is part of the drug, increases the time it takes for a blood clot to form.

It is strictly prohibited to take the drug together with alcohol. The medical literature describes a large number of cases of pathological symbiosis of pentalgin and alcohol. Even doctors do not recommend the simultaneous use of this painkiller and any drops of alcohol.

For a long time, Pentalgin was considered one of the best medications for relieving painful sensations during menstruation, and the pharmacy price of this medicine is quite affordable. The cost of 4 tablets ranges from 120 to 160 rubles.

We recommend reading the article about the drug “Ibuklin” for menstruation. From it you will learn about the pharmacological action of the medicine, indications for use and contraindications, instructions for use, and effectiveness during menstruation.

Modern pharmacological research has made it possible to develop a number of new drugs to reduce pain due to PMS. Experts are discovering more and more new negative qualities in the work of pentalgin. However, despite all this, this drug remains one of the most popular among patients who have problems with menstruation.

Source

special instructions

The simultaneous use of Pentalgin with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion should be avoided.

When using the drug Pentalgin for more than 5-7 days, peripheral blood counts and the functional state of the liver should be monitored.

Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

If it is necessary to determine 17-ketosteroids, Pentalgin should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.

The effect of caffeine on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

During the treatment period you should not drink alcoholic beverages.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, the patient must be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Abdominal pain

Pentalgin® tablets are film-coated. It dissolves in the stomach within 30 minutes after administration. However, Pentalgin® is not intended to relieve stomach pain. Its indications for use include: pain of various origins (pain in muscles and joints, pain with radiculitis, during menstruation, with neuralgia, toothache and headache, including headache caused by vasospasm); pain syndrome caused by spasm of smooth muscles, including renal colic, chronic cholecystitis, postcholecystectomy syndrome, cholelithiasis; pain after injury and surgery, including those accompanied by inflammation; ARVI accompanied by fever (as symptomatic therapy). In addition, erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), which are a common cause of stomach pain, are among the contraindications to the use of the drug Pentalgin®. To eliminate stomach pain, special medications are used, the choice of which depends on the exact diagnosis. For examination and diagnosis, we recommend contacting a gastroenterologist.

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase) are among the contraindications to the use of the drug Pentalgin®, that is, it cannot be used during exacerbation of gastric ulcer. In addition, the drug is contraindicated in some other diseases of internal organs: gastrointestinal bleeding; complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history); severe liver and/or kidney failure; inhibition of bone marrow hematopoiesis; severe organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent ventricular extrasystole, severe arterial hypertension. A complete list of contraindications and possible side effects is indicated in the instructions for medical use of the drug.

Source

Overdose

Symptoms: pale skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia (increased body temperature), frequent urination, headache, tremors or muscle twitching; epileptic seizures, increased activity of liver transaminases, hepatonecrosis, increased prothrombin time. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose, liver failure develops with progressive encephalopathy, coma, and death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help.

Treatment: gastric lavage followed by taking activated charcoal. The specific antidote for paracetamol poisoning is acetylcysteine. The administration of acetylcysteine ​​is important within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and gastric lavage with an ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; for epileptic seizures - intravenous administration of diazepam; maintaining fluid and salt balance.

Pentalgin: key characteristics

The drug works on 5 substances. The most famous is drotaverine, the main component of No-Shpa, which is an antispasmodic. Paracetamol is in most cases used as an antipyretic substance, but at the same time it also has a weak analgesic effect. Other main components of Pentalgin:

• Caffeine. A psychostimulant that tones the body, dilates blood vessels, and also enhances the effect of analgesics. In Pentalgin, it also neutralizes the hypotensive effect of drotaverine, so blood pressure drops less frequently when taking the tablet than when using No-Shpa.
• Naproxen. A non-steroidal anti-inflammatory substance that suppresses the production of prostaglandins and thereby reduces pain.
• Pheniramine. It is an H1-blocker of histamine, necessary to enhance the effect of analgesic components.

Thanks to this composition, Pentalgin has a very wide spectrum of action: it can cope with pain that is associated with muscle spasms, vascular, and inflammatory processes. For this reason, it is used in dental, gynecological, and gastroenterological practice. However, keep in mind that the drug does not cure, but only blocks the symptoms of the disease.

Painkillers for teenage girls

At the beginning of puberty after menarche, menstruation takes a long time to recover, often accompanied by pain of varying intensity.

• Painful sensations are associated with increased contraction of the muscles of the uterus, so to make you feel better, you should take antispasmodics.
• Before menstruation, due to multiple changes, blood pressure may decrease, which is why bleeding does not begin or is extremely scanty. In this case, experts recommend taking Citramon, which will dilate blood vessels and relieve spasms.
• Critical days in girls can be accompanied by severe pain due to the incorrect anatomical structure of the uterus, in particular - displacement, bending. The enlarged organ puts pressure on the nerve endings in the intestines, causing severe pain. In this case, the girl will be helped by single-component or combined painkillers. During childbirth, the uterus acquires the desired position, so in most cases painful menstruation stops.

Teenagers are allowed to take the same medications as adults, but it is advisable to understand the cause of the pain and select a medication with the correct mechanism of action. As for Analgin, the opinions of experts differ - some advise, others do not. In emergency cases, you can give the girl any painkiller, but you should not put her on pills, and you should not exceed the dosage. You are allowed to take no more than 2 painkillers and 4 antispasmodics per day.

How and who should take Pentalgin?

The main indications for use of the drug are joint and muscle pain, including neuralgia and pain during the menstrual cycle. The drug can also be taken for spasms of smooth muscles due to cholecystitis, cholelithiasis, and renal colic. Other indications:

• colds and flu with fever;
• toothache;
• inflammation after surgery or due to injury.

To make the medicine work faster, remember a few points:

• The absorption of the drug in oral form directly depends on the fullness of the digestive tract, so it is better to take the tablet on an empty stomach. The exception is people with gastritis, ulcers and other similar diseases.
• For the fastest possible effect, you should take the full dose if there are no contraindications.
• Long-term treatment with barbiturates reduces the effectiveness of Pentalgin.

The dosage of the medicine is determined by the doctor. Average values ​​for adults are 1 tablet up to 3 times a day for intense pain. As an analgesic, the drug is taken for no longer than 5 days. Pentalgin is prohibited for children, pregnant and lactating women. It is also contraindicated in cases of hypertension, liver failure, disorders of the hematopoietic process, internal bleeding, and erosions of the gastrointestinal mucosa.

How to get rid of menstrual pain?

Natural Relaxation Method

The first thing you can do is try to relieve severe pain without resorting to medications. To alleviate the condition, the following techniques are used:

• fetal position - lying down with your legs pressed to your body slightly relaxes the abdominal muscles;
• applying heat - during spastic pain, you can put a bottle of hot water or a heating pad on the lower abdomen, sometimes a stream of warm shower directed at the abdomen helps; heat acts as a natural antispasmodic, the main thing is not to overdo it: exposure to too high temperatures increases bleeding;
• “freezing” pain - some women experience relief after applying an ice bag or a cold heating pad; the cold constricts the blood vessels, resulting in dulling of the pain;
• aromatherapy - the smells of essential oils of bergamot, oregano, lavender or jasmine give a slight calming effect that will help you relax and relieve pain;
• massage - stroking the lower abdomen with light circular movements in a clockwise direction can normalize blood circulation in the lower abdomen, which helps eliminate spasms.

One of the most unusual methods for menstrual pain is having sex. Orgasm eliminates congestion in the blood vessels, thereby relieving spasms in the uterus.

Since the uterus is vulnerable to pathogenic microorganisms during menstruation, sexual contact is allowed only with a condom.

Painkillers for adult women

Spasms of the smooth muscles of the uterus are quickly relieved by antispasmodics. They are produced in the form of tablets, suppositories, and solution for intramuscular injection. Intramuscular injections work the fastest.

No-shpa is often used for menstrual pain

Among the most well-known medications are:

• No-shpa. The active component of the drug neutralizes the production of prostaglandins, relaxes the uterus, increasing bleeding. The pain goes away, but your periods are much more intense, which leads to the need to change pads more often. The daily dosage of No-shpa is 6 tablets;
• Buskopan. Designed to relieve spasms of smooth muscles of the genitourinary organs; you are allowed to drink no more than 5 tablets per day;
• Papaverine. More often used in the form of suppositories, it has an analgesic effect;
• Spazgan (Spazmalgon). It is used for all types of pain, including menstrual pain, and eliminates spasms in the uterus. Dosage: no more than 6 tablets per day;
• Galidor. In addition to the antispasmodic effect, it has mild sedative properties. Taken three times a day.

Read: Antidepressant Adepress

If pain occurs due to hormonal imbalance, women are advised to use contraceptives to normalize the balance of hormones: Yarina, Rigevidon, Ovidon, Diane-35, Lindinet.

Properties and Features

Pentalgin is a combined analgesic widely used in dentistry and other branches of medicine. In Soviet times, the drug was known as “pyatirichatka”, due to its multicomponent composition.

The drug is released in tablet form with a composition of five active components, each of which is responsible for performing a specific function:

• codeine - helps cope with pain (including dental diseases);
• naproxen - reduces elevated body temperature;
• caffeine - fights migraines;
• phenobarbital - has a calming effect;
• Metamizole sodium - increases the effectiveness of the active ingredients due to its activity.

Pentalgin is considered a fairly strong drug, so it can only be used in accordance with the instructions. In addition, the patient should be prepared for the possible occurrence of side effects. They usually occur due to individual intolerance, non-compliance with the manufacturer’s recommendations, or the presence of any diseases (including those mentioned in the list of contraindications). However, there are cases where undesirable reactions developed for no apparent reason. Therefore, those who take Pentalgin for the first time need to carefully monitor their own body’s reaction to the drug.

Taking Pentalgin can make changes in the functioning of several body systems: respiratory, nervous, digestive, cardiovascular, circulatory, etc. A number of patients taking painkillers developed allergic reactions, nausea and vomiting, problems with appetite, digestive disorders, pain in the stomach, dry mouth. Sometimes there were problems with sleep, impaired coordination of movements, headaches, problems with the heart and blood vessels, dysfunction of visual perception, increased anxiety, etc.

If at least one of the listed adverse reactions occurs while taking Pentalgin, you need to stop taking the analgesic and consult a doctor.

Pentalgin is not suitable for all patients, so in some cases it is changed to another medicine with a similar effect.

Compound

Bellalgin contains the following components:

• metamizole sodium 0.25 mcg;
• benzocaine 0.25 mcg;
• sodium bicarbonate 0.1 mcg;
• belladonna extract (leaves).

• Vaseline oil;
• potato starch;
• silicone emulsion;
• stearin;
• talc.

Excipients: microcrystalline cellulose, mannitol (E421), croscarmellose sodium, magnesium stearate, colloidal silicon dioxide.

Bellalgin contains benzocaine, belladonna leaf extract, sodium bicarbonate, and metamizole sodium.

Release form, composition and packaging

◊ Tablets, film-coated from light green to green, biconvex, capsule-shaped with beveled edges, scored on one side and embossed “PENTALGIN” on the other; When cut, the tablet is light green in color with white splashes.

Excipients: microcrystalline cellulose - 128 mg, potato starch - 55.38 mg, croscarmellose sodium - 32 mg, hyprolose (hydroxypropylcellulose) - 32.52 mg, citric acid monohydrate - 3 mg, butylated hydroxytoluene (E321) - 0.3 mg, magnesium stearate - 7.2 mg, talc - 16.12 mg, quinoline yellow dye (E104) - 0.4608 mg, indigo carmine (E132) - 0.0192 mg.

Shell composition: hypromellose (hydroxypropyl methylcellulose) - 12.17 mg, povidone (medium molecular weight medical polyvinylpyrrolidone, povidone K25) - 3.87 mg, polysorbate 80 (Tween 80) - 1.1 mg, titanium dioxide - 3.43 mg, talc - 4.218 mg, quinoline yellow dye (E104 ) - 0.2 mg, indigo carmine (E132) - 0.0127 mg, or Opadry 13A210001 Green shell (OPADRY 13A210001 GREEN) - 25.0007 mg [hypromellose - 12.17 mg, povidone - 3.87 mg, polysorbate 80 - 1.1 mg, titanium dioxide - 3. 43 mg, talc - 4.218 mg, quinoline yellow - 0.2 mg, DF&C blue #2 / indigo carmine - 0.0127 mg].

2 pcs. — cellular contour packages (1) — cardboard packs. 2 pcs. — contour cell packaging (2) — cardboard packs. 4 things. — cellular contour packages (1) — cardboard packs. 4 things. — contour cell packaging (2) — cardboard packs. 6 pcs. — cellular contour packages (1) — cardboard packs. 6 pcs. — contour cell packaging (2) — cardboard packs. 10 pieces. — cellular contour packages (1) — cardboard packs. 10 pieces. — contour cell packaging (2) — cardboard packs. 12 pcs. — cellular contour packages (1) — cardboard packs. 12 pcs. — contour cell packaging (2) — cardboard packs.

Indications

Pentalgin can be used for all types of toothache, but doctors recommend using it for pain of mild to moderate intensity. Sometimes the drug is used by patients independently, or as directed by a doctor. In particular, the doctor may recommend taking Pentalgin after dental surgery.

Pentalgin packaging

Sometimes toothache is so intense that this painkiller becomes powerless. This can happen with acute pulpitis, when the inflammatory process affects the pulp - the neurovascular bundle of the tooth. Therefore, if taking the drug does not bring the desired effect within 20-40 minutes, you should not increase the dose of the drug.

Doctors' opinion

Doctors generally recommend Pentalgin for use to relieve pain and do not express a categorical ban on this drug. However, taking it for more than 6 days without specialist supervision can be dangerous. Always notify your doctor when you start taking the drug and keep him informed of any changes in your body.

What does Pentalgin help with?

The drug has a combined pharmacological effect: analgesic; antipyretic (lowers temperature, relieves inflammation); antispasmodic effect. Pentalgin helps eliminate pain of various natures:

• in joints, muscles;
• toothache, headache;
• with spasm of the smooth muscles of internal organs;
• postoperative, caused by inflammation;
• symptomatic in febrile states during a cold.

Use in children

Sometimes a child suffers from toothache, and the parents’ task is to alleviate his condition by any means possible. Here you should be extremely careful: the use of Pentalgin in pediatrics is possible, but only if the child has reached 12 years of age. For younger children, the drug is not prescribed for one simple reason: codeine and phenobarbital inhibit the development and functioning of the central nervous system.

In addition, the multicomponent drug is removed from the body for too long, destroying internal organs and the aforementioned nervous system. Even if the child has reached the age of 12 years, you should not give him an analgesic without the permission of the pediatrician. The doctor must compare the expected benefits of taking Pentalgin and the possible harm, and also prescribe the optimal dosage taking into account the patient’s age and weight.

Contraindications

However, the drug "Pentalgin" cannot always be taken. There are contraindications that must be taken into account.

Pentalgin tablets should not be taken in case of the following phenomena:

• during periods of exacerbation of chronic diseases of the digestive system;
• stomach and duodenal ulcers;
• hypersensitivity to the components of the drug;
• bronchospasm;
• bronchial asthma;
• nasal polyps;
• kidney and liver damage accompanied by failure;
• arrhythmic manifestations;
• tendency to bleed;
• persistent hypertension;
• severe vascular disorders;
• hyperkalemia;
• surgical interventions on the aorta;
• allergic reactions to aspirin or other drugs from the NSAID category.

It is prohibited to treat children under 12 years of age, since there is no data on how Pentalgin tablets act on young patients.

With caution, painkillers are prescribed to older patients, after 65 years. Negative phenomena may occur when treating persons with epilepsy, diabetes mellitus and chronic pathologies of the liver and kidneys with Pentalgin.

The use of Pentalgin during pregnancy is prohibited, since the complex composition of the drug can cause damage to the fetus. This medicine is contraindicated for women who are breastfeeding.

If any negative reactions occur during treatment, it is important to inform your doctor. He will be able to select a drug that has a similar effect and does not cause unpleasant symptoms.

Side effects

After long-term use of the medicine, negative consequences may occur. In this case, you need to stop therapy and consult a doctor. Most often, anxiety symptoms go away on their own, but sometimes specialist intervention is necessary. Side effects from taking Pentalgin include the following:

• increased blood pressure;
• allergic reaction;
• exacerbation of chronic diseases of the digestive system;
• decreased concentration;
• sleep disturbance;
• deterioration of visual function;
• loss of appetite;
• cardiac arrhythmia.

Instructions for use

Pentalgin contains strong components that can harm the gastrointestinal tract. To avoid harmful effects on the body, it is recommended to take tablets before meals (30-40 minutes) or after meals (half an hour later). Doctors advise giving preference to the second option, since it is considered the safest.

The dosage should be selected by a doctor based on weight, age, pain intensity and some other factors. In general, the drug can be taken for 3-7 days. Longer use may lead to dependence and withdrawal symptoms. The maximum permissible number of tablets that can be taken per day is 3 pieces. Most often, 1 tablet is enough for temporary pain relief (for example, before going to the dentist).

Antispasmodic

Abuse of pills can cause an overdose, the most harmless consequences of which are headaches, vomiting and nausea. In more severe cases, disturbances in the functioning of the heart and respiratory organs, damage to the central nervous system and liver occur. Those who accidentally took a large dose of an analgesic are advised to perform gastric lavage.

It is important to remember that self-medication and uncontrolled use of medications (including painkillers) can cause much more serious problems than toothache.

Drug interactions

When taking the drug Pentalgin simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxicity increases (these combinations should be avoided).

Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

The simultaneous use of paracetamol with ethanol increases the risk of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

When used simultaneously with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity.

Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing its concentration in the blood).

Concomitant use of caffeinated beverages and other CNS stimulants may result in excessive CNS stimulation.

When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.

With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, the depressant effect on the central nervous system may be enhanced.

Analogs

The most common analogues of the pharmacological drug "Pentalgin" are the following medications:

These medications show the greatest therapeutic effectiveness only if they correctly replace the drug "Pentalgin". This should be done after consulting a doctor.

The approximate cost of this medication varies from 60 to 120 rubles (for a package of 4 tablets), from 100 to 150 rubles (for a package of 12 tablets) and from 155 to 230 rubles (for a package of 24 tablets). Below we find out what patients think about the drug.

How long does it take to work?

Those who take Pentalgin for toothache are interested in how long it takes for it to begin to have an effect. Usually, 20-35 minutes are enough to influence the nerves whose damage caused the pain. It is impossible to give an exact figure, since it depends on the individual characteristics of the body and body weight. Some patients feel pain relief after 15-20 minutes, others do not feel relief even after an hour.

The medicine lasts for five hours, which is enough to calmly wait for a dentist appointment.