Escapelle: the effectiveness of the drug, whether it helps and whether it may not work, how to understand that it has helped and who has not, and also, in what cases should you consult a doctor?

pharmachologic effect

Postcoital contraceptive with pronounced gestagenic and antiestrogenic effects. With the recommended dosage regimen, it suppresses ovulation and fertilization if sexual intercourse occurred in the preovulatory phase of the menstrual cycle, i.e. during the period of greatest likelihood of fertilization. In addition, the regression of endometrial proliferation caused by the drug prevents the implantation of a fertilized egg. Once implantation has taken place, the drug is ineffective.

If the recommended dosage regimen is followed, levonorgestrel does not have a significant effect on blood clotting factors, fat and carbohydrate metabolism.

taking Escapelle ® as soon as possible (but no later than 72 hours) after sexual intercourse, if no protective measures have been taken. The more time passes between sexual intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% from 24 to 48 hours, and 58% from 48 to 72 hours).

Reasons for delay after Escapelle

The factors that determine the delay of critical days after contraception include the following:

Hormonal imbalance

Artificially caused hormonal imbalance provokes a number of problems, especially in the endocrine system. These disorders often affect the regularity of menstruation. Normally, the cycle should be restored 2-3 months after using Escapel. If this does not happen, then you need to consult a doctor to restore and correct hormonal balance.

Pregnancy

At the moment, no means of protection provides absolute guarantees. Therefore, if your period does not come on time due to the drug, first do a pregnancy test to rule it out. If the test is positive, there is no need to worry about the condition of the fetus. Experts say that this medication does not have a negative effect on the fetus.

On what day of delay can an ultrasound be done to confirm pregnancy? Find the answer to this question in the article at the link.

Ectopic pregnancy

If there is a delay, the test does not give a clear result, the lower abdomen tightens, and general health gradually worsens, then these are symptoms of an ectopic pregnancy. This often happens due to improper use of the medication. There are common cases when taking a pill in a woman caused a gag reflex, and she did not have time to have the full effect. In such a situation, you should take a second tablet to achieve the desired result, having first consulted a doctor about this.

Changes in blood clotting

A delay after Escapelle with a negative test in some cases means a change in the circulatory system. Sometimes gestagens can cause increased blood clotting. For these reasons, during endometrial rejection, the blood quickly clots and is not released during scheduled periods or is indicated by a scanty brown smear. Because of this, instead of menstruation, in rare cases small dark bloody clots are observed.

Effect of alcohol

This substance completely blocks the action of the active component - a synthetic hormone, which reduces the effectiveness of the tablets to nothing. For this reason, it is necessary to avoid drinking alcoholic beverages for at least the first 2 to 3 days after taking the pill.

Incompatibility of medications

The influence of substances contained in other drugs that are taken in parallel with Escapel often reduces its effectiveness, which does not lead to the expected result, but delays the onset of menstruation.

Pharmacokinetics

Suction

After oral administration, levonorgestrel is quickly and completely absorbed from the gastrointestinal tract. Cmax of the active substance in plasma is reached after 2 hours and is 18.5 ng/ml. Absolute bioavailability is 100%.

Distribution

Levonorgestrel binds to albumin and sex hormone binding globulin (SHBG). 1.5% of the total amount in plasma is in the form of free steroid, 65% is specifically associated with SHBG.

Metabolism

The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver and metabolites are excreted in the form of conjugated glucuronides. Pharmacologically active metabolites of levonorgestrel are unknown.

Removal

After reaching Cmax, plasma concentrations of levonorgestrel decrease. T1/2 is 26 hours. Levonorgestrel is excreted approximately equally by the kidneys and through the intestines exclusively in the form of metabolites.

Pharmacokinetics in special clinical situations

Gastrointestinal diseases that occur with malabsorption reduce the absorption of the drug, which may affect its effectiveness.

Indications for use

When should I take Escapelle? The instructions say the following: the remedy is prescribed if unprotected sexual intercourse has already occurred, and pregnancy is undesirable for this period.

This is not the only indication. There are times when the main means of protection are not reliable enough.

For example, if you are using hormonal contraceptives, but are being treated with antibiotics or taking medications containing St. John's wort extract. Then you can resort to emergency contraception once (if you forgot about the decrease in the effectiveness of COCs, and intimacy has already occurred), and then use condoms until the end of the course of treatment.

Another indication may be a condom breaking.

The drug is contraindicated for use during pregnancy. Although if we exclude the first trimester, it is unlikely that a woman can doubt her interesting situation and continue to use emergency contraception.

However, the studies conducted do not confirm the negative effect of the drug on the fetus. Therefore, if, despite precautions, the pregnancy continues, then you can safely carry your baby and not worry about his health.

As already mentioned, the drug is excreted in breast milk, so after taking it you should temporarily stop breastfeeding. After two days, you can return to your usual routine.

Dosage regimen

The drug is taken orally at a dose of 1.5 mg (1 tablet) as soon as possible, but no later than 72 hours after unprotected sexual intercourse (the effectiveness of emergency contraception with delayed use of the drug is significantly reduced). If vomiting occurs within 3 hours after administration, Escapel ® should be taken again at a dose of 1.5 mg (1 tablet).

The drug can be used at any time of the menstrual cycle. In case of irregular menstrual cycle, pregnancy must be excluded.

After taking Escapel ® , local barrier methods of contraception (for example, a condom) should be used until the next menstruation. The use of the drug during repeated unprotected sexual intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic spotting/bleeding.

How Escapelle affects menstruation

Many women have encountered situations where they need to urgently use contraception after intimate intercourse. For this purpose, there are a number of drugs, the features of which you need to know initially.

For example, menstruation after Escapelle may proceed in a normal rhythm, or it may change with little predictable probability.

They are influenced by various factors, from the characteristics of the body and the frequency of taking contraceptives, to the phase of the cycle in which the drug was taken.

Why do people drink Escapelle?

Popular emergency contraceptive drugs include Escapelle, which helps minimize the risks of unwanted pregnancy. It is taken after intimacy; its composition is similar to its predecessors, but it allows you to get the expected effect with a single dose. However, after this, a disturbance in the monthly cycle is often observed, from a delay to the early onset of menstruation.

The contraceptive is a gestagenic drug, which allows it to be used by women of different age groups. It is not prohibited for use during lactation, but you need to take the pill six hours before breastfeeding. It is also necessary to take into account that Escapelle does not exclude pregnancy if there was repeated unprotected sex after taking it.

If you experience scanty periods after taking the pill, it is recommended to take a blood test for “pregnancy hormone” (hCG), or conduct a test yourself. The effectiveness of the drug is noted when taken within seventy-two hours after sexual intercourse.

It is believed that its effect lasts more than a hundred hours, but the shorter the period after intimacy and taking the pill, the higher the effectiveness of the contraceptive.

It is also possible to take Escapelle during menstruation, but menstruation may last several days longer, or light spotting may appear after ten to fourteen days.

When is Escapelle necessary:

Rape;
High probability of conception when other contraceptives are not recommended;
The schedule for taking oral contraceptives is disrupted;
Casual unprotected sex;
In case of spontaneous removal of the vaginal ring, intrauterine device, or damage to the condom;
Other situations where there is a high probability of unwanted pregnancy.

Operating principle

The active substance of the drug is Levonogestrel, which acts on the woman’s body in a complex manner in several directions, which makes it possible to achieve a 99% chance of eliminating unwanted pregnancy.

Under the influence of Escapelle:

The onset of the ovulation period is delayed;
Eggs mature more slowly;
Cervical mucus thickens in the cavity and cervix, which makes it difficult for the fertilized egg to advance;
The endometrium does not develop, which prevents the implantation of fertilized eggs.

It should be noted that menstrual irregularities depend on the phase of the ovulation period when the drug was taken.

Failure of the menstrual cycle

If menstruation begins on time or ahead of schedule, a woman may understand that pregnancy has not occurred, but if there are no periods, the risks of an unplanned pregnancy are high. However, a delay in menstruation after Escapel is a fairly common occurrence, because the drug disrupts the menstrual cycle.

In the first phase of the cycle

Half of women mistakenly believe that they got their period the next day if the drug is taken before ovulation, although in reality it is a daub.

The discharge is perceived as menstruation that began ahead of schedule, so they are quite surprised when the discharge recurs after a couple of weeks. The reason lies in hormonal imbalance, which prevents the development of eggs.

Regardless of whether they started early or on time, scanty periods usually pass. The reason is simple: the endometrial layer does not develop enough under the influence of hormones, which means there is nothing special to reject.

In the second phase

Menstruation after taking the drug in the second phase may also be disrupted, because the high level of progesterone prepares the body for pregnancy, despite the fact that fertilization has not occurred.

During this period, the endometrium grows, the discharge becomes thicker, and menstruation may be delayed for days or even several weeks.

Sometimes in the middle of the cycle there is spotting, but the delay can reach twenty days, after which heavy discharge begins.

During menstruation itself

There is a common stereotype that during menstruation, a woman cannot become pregnant. In fact, sex at the end and beginning of your period has a high chance of resulting in pregnancy.

Therefore, it is necessary to take care of contraception even during such a piquant period.

Please note that taking Escapel during menstruation may cause a small amount of bloody discharge to appear after ten to fourteen days, or prolong menstruation by several days.

Other disorders and consequences of taking the drug

As a result of a single dose of a high dose of a hormonal drug, functional changes may occur in the mammary glands, expressed as an increase in size, tension, and pain. This discomfort lasts for two to three weeks.

Before menstruation or spotting, you may experience pain in the lower back and lower abdomen, and the menstruation itself may also be more painful.

If a woman has impaired kidney or liver function, Escapelle should be taken only after consultation with a doctor, and if there are diseases of the digestive system, the effect of the drug may be reduced.

In some cases, taking Escapel leads to adverse reactions, such as:

Allergy;
Nausea, vomiting;
Diarrhea;
Fatigue;
Dizziness;
Headache;
Sense of anxiety.

Escapelle is an effective drug designed for use by women of different age groups. Also, the reasons for its popularity include affordable cost and good tolerability, low likelihood of adverse reactions. Disorders in the menstrual cycle are caused by high levels of hormones and this disruption is eliminated fairly quickly.

Side effect

Allergic reactions:

possible - hives, rash, itching, swelling of the face.

The following are transient adverse reactions that occur with different frequencies and do not require drug therapy: very often (≥1/10), often (≥1/100, 1/10).

From the digestive system:

very often - nausea; often - vomiting, diarrhea.

From the side of the central nervous system:

very often - fatigue; often - headache, dizziness.

From the reproductive system:

very often - pain in the lower abdomen, acyclic spotting (bleeding); often - soreness of the mammary glands, delayed menstruation (no more than 5-7 days). If menstruation is delayed for a longer period, pregnancy must be excluded.

Dosage, indications and contraindications, price

The instructions that come with each package state that you need to take 1 tablet with water. The time of use is not tied to meals or days of the cycle, but it is necessary to bring it as close as possible to the end of sexual intercourse.

During the three hours following taking the pill, the woman may vomit. In this case, it is necessary to repeat the procedure. “Escapel” has a one-time effect, and during subsequent sexual contacts, in order to protect against pregnancy, it will be necessary to use barrier contraception.

The use of contraceptive pills "Escapelle" is indicated in cases where sexual intercourse can be defined as unprotected:

the condom has not been used or its integrity has been damaged;
intended for regular use was missed
the intercourse was forced or there was rape.

The drug is quite effective only if no more than 72 hours have passed since the completion of sexual contact.

special instructions

This drug is intended solely for emergency contraception and does not replace regular contraception. Repeated use of Escapelle ® during one menstrual cycle is not recommended.

Escapelle ® should be taken as soon as possible, but no later than 72 hours after unprotected sexual intercourse. The effectiveness of emergency contraception with delayed use of the drug is significantly reduced.

In most cases, Escapelle ® does not affect the nature of the menstrual cycle. However, acyclic bleeding and a delay of menstruation for several days are possible. If menstruation is delayed by more than 5-7 days and there is a change in its nature (scanty or heavy discharge), pregnancy must be excluded. The appearance of pain in the lower abdomen and fainting may indicate an ectopic (ectopic) pregnancy.

Adolescents under 16 years of age, in exceptional cases (including rape), need to consult a gynecologist to confirm pregnancy. After emergency contraception, a consultation with a gynecologist is recommended to select the most appropriate method for permanent contraception.

Emergency contraception does not protect against sexually transmitted diseases.

In case of gastrointestinal dysfunction (for example, Crohn's disease), the effectiveness of the drug may be reduced.

Impact on the ability to drive vehicles and operate machinery

The effect of the drug on the ability to drive vehicles and other mechanisms has not been studied.

escapelle how to find out if it worked and there is no pregnancy

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An unwanted pregnancy is definitely not a gift, especially if it can happen through negligence or accident.

However, there are medical treatments that can prevent such severe consequences with a high degree of probability.

How does Escapelle work?

Taking the pill is an effective method of emergency protection against pregnancy. The tablets contain a synthetic hormone - progestogen (a substance close to progesterone). This component is also known as levonorgestrel. The action of Escapel is aimed at suppressing the synthesis of estrogen.

Thus, the mechanism of action of this drug causes a shift in the hormonal balance in the female body and leads to significant difficulty in conception. Escapelle also makes the cervical mucus thicker, which prevents sperm from moving through it.

In addition, there is a failure in the formation of the endometrial layer and a slowdown in the release of the egg from the follicle . All together prevents the blastocyst from forming and gaining a foothold in the uterus. This is the operating principle of Escapelle.

Efficiency of reception

Due to the fairly rapid mechanism of pregnancy, you need to understand how long it takes for Escapelle to act. Therefore, you need to take the drug no later than 72 hours (3 days) after unprotected coitus . Over time, the effectiveness of the pills decreases and the likelihood that pregnancy will take shape increases.

After the blastocyst is fixed in the uterus, Escapelle has no effect on it, i.e. It is impossible to perform a home abortion in the early stages using it.

Taking the drug after the 72-hour mark is ineffective , although there is data on permissible

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Please tell me about the dangers of postinor: I took it four times in 3 months, two doses were at intervals of a week, the rest were about a month apart. It happened this way because... provided condoms.

Recently I came across it on some forum where both doctors and non-doctors discussed it, they wrote that it was disgusting and should not be accepted, that it was like a time bomb - if there are no consequences right away, then they will definitely come later, maybe in years, and it can take to infertility or pregnancy pathologies, fetal pathologies...

They wrote that this is a very powerful dose of the hormone, which the body itself does not produce in a year. Some doctors (or non-doctors, who knows) claim that abortion is better... Also, many wrote about long-term hormonal imbalances.

I didn’t have them (there were no consequences at all, except maybe weakness and mild nausea), but for a long time now every period is very heavy, using a large tampon and pad, I don’t have time to get to work - I get wet...

But what frightens me most of all is the described consequences for the future. Everyone and everywhere says and writes that it is very harmful, but the word “harmful” is an evaluative concept, non-specific, it is not clear to me exactly why it is harmful, what consequences it may have, what it affects, although the mechanism of action is clear (rejection of the endometrium).

As an alternative, they also write that it is better to take a COC in emergency cases - Marvelon or Mercilon. Is it better to take something else (Marvelon or Mercilon) in emergency cases - or is it actually the same thing? Or should I never do this again?

Is taking Postinor an abortion? I believed that this was still a method of contraception in case other methods had failed, and that it still had a contraceptive effect (i.e., prevent pregnancy), and not a “killer” one (i.e., destroy an existing pregnancy).

This is a large dose of the hormone - very large

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HELP!!! Postinor and pregnancy

I took Postinor 2 weeks ago for emergency contraception (we didn’t plan it yet - I decided to play it safe), now there’s a delay, the test showed pregnancy.

Does anyone have experience or know anything about this? Please tell me what are the risks of affecting the development of the fetus if the pregnancy continues, there is a lot of conflicting information? Are there any statistics, is it recommended to officially terminate such a pregnancy, at what stage will it be known whether there are pathologies or not, and what pathologies can be caused by the active substance of the postinor? I would like to continue the pregnancy.

Hello, I found out that I was pregnant on the first day of my missed period, and I immediately took Postinor. The next day I went to the hospital, where they gave me 5 weeks. Now I want to have a baby. Will Postinor affect the child and can I give birth now?

Postinor is effective within 72 hours after conception, this is not a method of terminating a pregnancy, naturally, it did not work and could not work, everything is fine. Bear and give birth.

The instructions for Postinor itself contain the following line: Postinor cannot be taken during pregnancy; the drug does not terminate an existing pregnancy. In the event of pregnancy with the use of progestogens, a teratogenic effect has not been identified. Terratogenic means the ability to cause the development of congenital deformities...

– If pregnancy nevertheless develops against the background of Postinor, or the drug was taken against the background of an existing pregnancy, the risk of negative effects on the fetus has not been established.

on one of the forums there is a discussion - I have a friend who gave birth to a “post-postinor” child - an absolutely healthy boy, and doctors say that the results of pregnancies after postinorus are usually normal.

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Dear ladies!! If you know everything about Postinor, please tell me! I took Postinor urgently 9.5 hours after unprotected PA, the second after 12 hours. Tell me whether there will definitely be bleeding 5-7 days after taking Postinor..

or wait for my period? or not to wait?(((how did this go for you?......now I have pain in the lower abdomen, like during menstruation, and constant weakness. Please do not write about the dangers of this crap.

Please let me know how this went! Thank you so much!!

I drank just like you, a terrible hormonal imbalance occurred, there was no bleeding, but after that I was treated for a long time. In general, it’s tin, not pills:(((((

why do you all take 2 tablets??? I drank one... and nothing bad happened to me. month they just arrived earlier and that’s it. and I was feeling as usual

I didn’t have any bleeding, my period came on time, but after that appointment my cycle was a little off. Previously it was like clockwork, but now +/- a few days..:-(

I had a terrible hormonal imbalance after taking it. Lethargy, dizziness, vomiting. My period arrived on time, or maybe it wasn’t my period, because... after 1.5 weeks it started.

I took Postinor several times. the first time there was no bleeding and my periods went as expected. Then immediately after taking it, I started bleeding for the next few days, I don’t remember. But the last time I took my period, my period was also delayed by 33 days. although I always have a stable cycle of no more than 31 days. I took Postinor for a long time, about 10 years, and of course only in emergency cases.

8, yes there are analogues! I don’t remember the names, ask at the pharmacy... however, I also recently had to take emergency measures, so there was one postinor available (((((((softer analogues, so they are sorted out faster...

shins hurt during pregnancy The reason for the pain is simple and obvious; every kilogram of body weight gained during pregnancy increases the load on the knee joints and feet several times. It's like you're carrying a big extra with you.

ON THE TOPIC - until the last case, when taking postinor there were ALWAYS early bleeding, despite the fact that I

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They wrote that this is a very powerful dose of the hormone, which the body itself does not produce in a year. Some doctors (or non-doctors, who knows) claim that abortion is better... Also, many wrote about long-term hormonal imbalances.

I didn’t have them (there were no consequences at all, except maybe weakness and mild nausea), but for a long time now every period is very heavy, using a large tampon and pad, I don’t have time to get to work - I get wet...

Is taking Postinor an abortion? I believed that this was still a method of contraception in case other methods had failed, and that it still had a contraceptive effect (i.e., prevent pregnancy), and not a “killer” one (i.e., destroy an existing pregnancy).

38 weeks of pregnancy, stomach pains, pregnancy is a very important period in the life of every woman. Parents take the birth of a new life very seriously and responsibly. It is the duty of the expectant mother to take care of her health.

Pay attention to any

This is a large dose of the hormone - very large

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The drug Escapelle, produced by the Hungarian pharmaceutical company Gedeon Richter, is one of the widely used emergency post-coital contraception.

When starting to use it, you need to understand the principle of action and find out on what factors its effectiveness depends.

Mechanisms of action of the drug

Escapelle is a progestin containing leronorgestrel intended for emergency contraception . Its release form is flat round tablets, white or as close to this color as possible. Each tablet has a line mark and GOO engraving. One package contains a single tablet for one-time use.

These tablets are indicated for use after unprotected sexual intercourse, as well as if a woman has doubts about the reliability of the contraceptive used.

Having a progestogenic effect, the drug suppresses any activity of estrogen, including delaying the onset of ovulation, minimizing the possibility of fertilization of the egg at a time when the probability of pregnancy is highest - namely, in the preovulatory phase.

Escapelle is able to change the usual state of the uterine mucosa so that a fertilized egg cannot get inside it.

Efficiency of Escapelle

According to statistics, using Escapel tablets can prevent unwanted pregnancy in 85% of cases.

Escapelle has helped many women, but the effectiveness of this drug depends on how well it is taken , so you need to remember simple rules and follow them:

if unprotected coitus occurs

Source

Source: https://9mpregn.ru/post/6020-eskapel_kak_uznat_chto_podeystvoval_i_net_beremennosti

Drug interactions

With simultaneous use of the drug Escapel ® with liver enzyme inducers, the metabolism of levonogestrel is accelerated.

The contraceptive effect of Escapelle ® is reduced when used simultaneously with the following drugs: amprenavir, lanzoprazole, nevirapine, oxycarbazepine, tacrolimus, topiramate, tretinoin, barbiturates, including primidone, phenytoin and carbamazepine, drugs containing St. John's wort ,

as well as rifampicin, ritonavir, ampicillin, tetracycline, rifabutin, griseofulvin.

Escapel ® reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenindione) drugs.

Levonorgestrel increases plasma concentrations of GCS.

Drugs containing levonorgestrel may increase the risk of cyclosporine toxicity due to inhibition of its metabolism.

How to avoid delay

Even the most experienced gynecologist cannot predict how your periods will go after Escapelle. Most of the women who took this drug noted disruptions in their cycle in the form of a delay in menstruation. It is impossible to avoid this, since here there is interference in one of the most delicate systems of the body - the hormonal one. But you can reduce the risks by following a few simple rules:

Use the contraceptive in strict accordance with the instructions.
Do not use if at least one of the contraindications is present.
You should take the pill no later than 72 hours after unprotected sex.
Avoid concurrent use of other medications.
Do not drink alcohol together with the drug.
Treat your body kindly after such a serious load in the form of using Escapel.
Do not abuse the use of these tablets (take no more than once every six months).

From reviews on forums and from the words of women, it follows that most of them had a delay in their periods after Escapelle. This is not a side effect, but is characterized as a consequence of the effect of levonorgestrel on the menstrual cycle. Such a serious intervention forces you to weigh the pros and cons of using these pills, because it is wiser to foresee the situation than to later try to correct it using emergency methods.

The drug and its analogues

Women often ask: “Is it better to use Escapelle or Postinor?” Both drugs contain the same dose of the same hormone, only in the case of the drug “Postinor” you are offered a package with two tablets, 0.75 mg each, they must be taken with an interval of 12 hours.

"Escapel" is represented by one tablet, which contains 1.5 mg of active ingredient.

It can be taken at once or divided into 2 doses. The most important thing is not which drug to choose, but how quickly to take it.

In the case of emergency contraception, time is of the essence.

Admission rules

It would be good to consult with your doctor before taking Escapelle. The instructions for use recommend taking the required dose of the drug within 2 days after the act of intimacy.

It will be 1.5 mg, or 1 tablet.

On an individual basis, the doctor may recommend dividing the dose into 2 doses: 0.5 tablets at first and the second half after 12 hours.

Indications for this may include poor health, young age, or low body weight.

If an individual reaction of the body occurs in the form of vomiting (especially if less than three hours have passed after taking the drug), then you should take the same dose again as the first time. At the same time, it is recommended to take the medication “Cerucal” in the amount of one tablet to prevent the appearance of the gag reflex and allow the drug to work.

What else do you need to know before taking Escapelle? The instructions for use indicate the possibility of using it on any day of the cycle. This is true, but only if the previous menstruation was normal and on time.

In other words, you must be sure that you are not pregnant today. There is no data on the pathogenic or toxic effects of the drug on the fetus, but any hormonal shift is dangerous, especially if you decide to continue the pregnancy.